Abstract: The invention relates to relatively short conotoxin peptides, about 10-20 residues in length as described herein, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. These conotoxin peptides have analgesic activity and are thus useful for treating or preventing pain.
Type:
Grant
Filed:
July 19, 2004
Date of Patent:
May 6, 2008
Assignees:
Xenome, Ltd., Cognetix, Inc.
Inventors:
J. Michael McIntosh, Baldomero M. Olivera, Lourdes J. Cruz, Gloria P. Corpuz, Robert M. Jones, James E. Garrett