Patents Assigned to XenoPort, Inc.
  • PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF
    Publication number: 20160090353
    Abstract: The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pharmaceutical compositions of prodrugs of GABA analogs for treating or preventing common diseases and/or disorders.
    Type: Application
    Filed: December 8, 2015
    Publication date: March 31, 2016
    Applicant: XENOPORT, INC.
    Inventor: Mark A. Gallop
  • Methods of synthesizing a levodopa ester prodrug
    Patent number: 9290445
    Abstract: Methods of synthesizing a levodopa ester prodrug, salts thereof, and synthetic intermediates thereof are disclosed.
    Type: Grant
    Filed: October 19, 2009
    Date of Patent: March 22, 2016
    Assignee: XenoPort, Inc.
    Inventors: Stephen P. Raillard, Adam Mann, Suresh K. Manthati, Randall A. Scheuerman, Tono Estrada, Mark Q. Nguyen, Cindy X Zhou
  • Anhydrous and hemihydrate crystalline forms of an ()-baclofen prodrug, methods of synthesis and methods of use
    Patent number: 9265748
    Abstract: Crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxyl)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate and crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxyl)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid hemihydrate, pharmaceutical compositions comprising such compounds, methods of making and methods of using the same are disclosed.
    Type: Grant
    Filed: July 14, 2015
    Date of Patent: February 23, 2016
    Assignee: XenoPort, Inc.
    Inventors: Stephen P. Raillard, Suresh K. Manthati, Sudhir Joshi
  • Prodrugs of gaba analogs, compositions and uses thereof
    Patent number: 9238616
    Abstract: The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pharmaceutical compositions of prodrugs of GABA analogs for treating or preventing common diseases and/or disorders.
    Type: Grant
    Filed: July 6, 2015
    Date of Patent: January 19, 2016
    Assignee: XenoPort, Inc.
    Inventor: Mark A. Gallop
  • CRYSTALLINE FORM OF y-AMINOBUTYRIC ACID ANALOG
    Publication number: 20150353483
    Abstract: A crystalline form of a ?-aminobutyric acid analog, and methods of preparing same, are provided.
    Type: Application
    Filed: August 20, 2015
    Publication date: December 10, 2015
    Applicant: XENOPORT, INC.
    Inventors: Tono Estrada, Stephen P. Raillard, Christine Hook-Frauenfelder, Uwe Zacher
  • ANHYDROUS AND HEMIHYDRATE CRYSTALLINE FORMS OF AN (R)-BACLOFEN PRODRUG, METHODS OF SYNTHESIS AND METHODS OF USE
    Publication number: 20150313865
    Abstract: Crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxyl)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate and crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxyl)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid hemihydrate, pharmaceutical compositions comprising such compounds, methods of making and methods of using the same are disclosed.
    Type: Application
    Filed: July 14, 2015
    Publication date: November 5, 2015
    Applicant: XenoPort, Inc.
    Inventors: Stephen P. Raillard, Suresh K. Manthati, Sudhir Joshi
  • Crystalline form of ?-aminobutyric acid analog
    Patent number: 9150503
    Abstract: A crystalline form of a ?-aminobutyric acid analog, and methods of preparing same, are provided.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: October 6, 2015
    Assignee: XenoPort, Inc.
    Inventors: Tono Estrada, Stephen P. Raillard, Christine Frauenfelder, Uwe Zacher
  • Anhydrous and hemihydrate crystalline forms of an ()-baclofen prodrug, methods of synthesis and methods of use
    Patent number: 9139517
    Abstract: Crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate and crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid hemihydrate, pharmaceutical compositions comprising such compounds, methods of making and methods of using the same are disclosed.
    Type: Grant
    Filed: November 11, 2013
    Date of Patent: September 22, 2015
    Assignee: XenoPort, Inc.
    Inventors: Stephen P. Raillard, Suresh K. Manthati, Sudhir Joshi
  • COCRYSTALS OF (N,N-DIETHYLCARBAMOYL)METHYL METHYL (2E)BUT-2-ENE-1,4-DIOATE
    Publication number: 20150157590
    Abstract: Disclosed herein are cocrystals of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, which is a prodrug of methyl hydrogen fumarate.
    Type: Application
    Filed: November 5, 2013
    Publication date: June 11, 2015
    Applicant: XenoPort, Inc.
    Inventors: Chen Mao, Scott L. Childs
  • METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS
    Publication number: 20150158809
    Abstract: Methods of preparing carbamate prodrugs of amine-containing drugs are provided. Carbonates useful in the synthesis of the carbamate prodrugs are also provided.
    Type: Application
    Filed: February 25, 2014
    Publication date: June 11, 2015
    Applicant: XENOPORT, INC.
    Inventors: Huan Wang, Peng Liu, Qunying Dai, Hao Yin, Stephen P. Raillard
  • Morpholinoalkyl fumarate compounds, pharmaceutical compositions, and methods of use
    Patent number: 8952006
    Abstract: Morpholinoalkyl fumarates, pharmaceutical compositions comprising the morpholinoalkyl fumarates, and methods of using morpholinoalkyl fumarates and pharmaceutical compositions for treating neurodegenerative, inflammatory, and autoimmune disorders including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are disclosed.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: February 10, 2015
    Assignee: XenoPort, Inc.
    Inventors: Kenneth C. Cundy, Suresh K. Manthati, David J. Wustrow
  • GABA analog prodrug sustained release oral dosage forms
    Patent number: 8906412
    Abstract: Sustained release oral dosage forms of a gabapentin prodrug, 1-{[(?-isobutanoyloxyethoxy)carbonyl]aminomethyl}-1-cyclohexane acetic acid, are disclosed. The dosage forms are useful for treating or preventing diseases and disorders for which gabapentin is therapeutically effective.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: December 9, 2014
    Assignee: XenoPort, Inc.
    Inventors: Kenneth C. Cundy, Srikonda Sastry, Manshiu Leung, Balaji V. Kadri, Paul E. Stach
  • Oral Dosage Forms of Methyl Hydrogen Fumarate and Prodrugs Thereof
    Publication number: 20140348915
    Abstract: Improved oral dosage forms of methyl hydrogen fumarate and prodrugs thereof are disclosed. Methods of treating diseases such as multiple sclerosis and psoriasis using such dosage forms are also disclosed.
    Type: Application
    Filed: August 22, 2013
    Publication date: November 27, 2014
    Applicant: XenoPort, Inc.
    Inventors: Sami Karaborni, Laura Elizabeth Bauer, Chen Mao, Ching Wah Chong, David J. Wustrow, Peter A. Virsik
  • Oral Dosage Forms of Methyl Hydrogen Fumarate and Prodrugs Thereof
    Publication number: 20140348914
    Abstract: Improved oral dosage forms of methyl hydrogen fumarate and prodrugs thereof are disclosed. Methods of treating diseases such as multiple sclerosis and psoriasis using such dosage forms are also disclosed.
    Type: Application
    Filed: August 22, 2013
    Publication date: November 27, 2014
    Applicant: XenoPort, Inc.
    Inventors: Sami Karaborni, Sarina Grace Harris Ma, Chen Mao, Ching Wah Chong, Peter Robert Prinz Freed, Mesut Ciper, Stefanie Krenzlin, David J. Wustrow, Peter A. Virsik
  • Methods of Administering Monomethyl Fumarate and Prodrugs Thereof Having Reduced Side Effects
    Publication number: 20140350018
    Abstract: Methods of reducing undesirable side effects during therapeutic treatment using monomethyl fumarate and prodrugs of monomethyl fumarate are disclosed.
    Type: Application
    Filed: August 22, 2013
    Publication date: November 27, 2014
    Applicant: XenoPort, Inc.
    Inventors: Kenneth C. Cundy, Sami Karaborni, Peter A. Virsik
  • PHARMACEUTICAL COMPOSITIONS OF DIMETHYL FUMARATE
    Publication number: 20140284245
    Abstract: Pharmaceutical compositions and dosage forms of dimethyl fumarate containing low levels of certain impurities are disclosed.
    Type: Application
    Filed: March 24, 2014
    Publication date: September 25, 2014
    Applicant: XenoPort, Inc.
    Inventors: Sami Karaborni, Wei Chen, Suresh Kumar Manthati
  • Methods of Administering Monomethyl Fumarate
    Publication number: 20140275250
    Abstract: Methods of therapeutic treatment using monomethyl fumarate are disclosed.
    Type: Application
    Filed: August 22, 2013
    Publication date: September 18, 2014
    Applicant: XenoPort, Inc.
    Inventor: Kenneth C. Cundy
  • METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS
    Publication number: 20140243544
    Abstract: Methods of preparing carbamate prodrugs of amine-containing drugs are provided. Carbonates useful in the synthesis of the carbamate prodrugs are also provided.
    Type: Application
    Filed: February 25, 2014
    Publication date: August 28, 2014
    Applicant: XENOPORT, INC.
    Inventors: Huan Wang, Peng Liu, Qunying Dai, Hao Yin, Stephen P. Raillard
  • CRYSTALLINE FORM OF y-AMINOBUTYRIC ACID ANALOG
    Publication number: 20140235710
    Abstract: A crystalline form of a ?-aminobutyric acid analog, and methods of preparing same, are provided.
    Type: Application
    Filed: March 12, 2014
    Publication date: August 21, 2014
    Applicant: XenoPort, Inc.
    Inventors: Tono Estrada, Stephen P. Raillard, Christine Frauenfelder, Uwe Zacher
  • GABA analog prodrug sustained release oral dosage forms
    Patent number: 8795725
    Abstract: Sustained release oral dosage forms of a gabapentin prodrug, 1-{[(?-isobutanoyloxyethoxy)carbonyl]aminomethyl}-1-cyclohexane acetic acid, are disclosed. The dosage forms are useful for treating or preventing diseases and disorders for which gabapentin is therapeutically effective.
    Type: Grant
    Filed: November 3, 2005
    Date of Patent: August 5, 2014
    Assignee: XenoPort, Inc.
    Inventors: Kenneth C. Cundy, Srikonda Sastry, Manshiu Leung, Balaji V. Kadri, Paul E. Stach