Abstract: Materials immunoreactive with parathyroid hormone-related protein (PTH-rp) are used in the invention method to prevent and treat cancer metastasis to bone and cancer cell growth in bone as well as osteolysis and symptomatic sequelae thereof. Antibodies with human characteristics are included in the invention for application of the invention method to human subjects.
Type:
Grant
Filed:
February 9, 1995
Date of Patent:
November 30, 1999
Assignee:
Xenotech
Inventors:
Toshiyuki Yoneda, Gregory R. Mundy, Theresa A. Guise