Abstract: The present invention provides compositions and methods for lowering blood glucose. More specifically, the present invention provides compositions comprising a complex comprising IF and B12 conjugated to a peptide comprising a GLP-1 agonist. Advantageously, the composition may be delivered subcutaneously.
Type:
Grant
Filed:
April 26, 2021
Date of Patent:
October 3, 2023
Assignees:
Syracuse University, Xeragenx LLC
Inventors:
Robert Doyle, Jonathan D. Bortz, David S. Hermelin
Abstract: The present invention relates to the use of transgenic plants for the expression of vitamin B12 (cobalamin) binding proteins. Plant cells are transformed with nucleotide sequences adapted for expression and secretion of vitamin B12 binding proteins. The present invention also relates to the use of recombinant vitamin B12 binding proteins from plants in analytical tests and treatment of vitamin B12 deficiency. Also disclosed is a method for purification of recombinant vitamin B12 binding proteins.
Type:
Grant
Filed:
January 22, 2009
Date of Patent:
September 5, 2017
Assignee:
XERAGENX LLC
Inventors:
Lars Erik Berglund, Torben Ellebaek Petersen, Sergey Nikolaevich Fedosov, Ebba Nexo, Niels Bech Laursen, Erik Ostergaard Jensen