Abstract: Methods and systems for determining the presence of disease in a subject by determining the state of modification (e.g. methylation) of a random subset of loci across the genome by sequencing and/or methylation detection is provided, where the composition of the random subset may differ from one sample to another.
Abstract: The present invention relates to methods of determining the sequence of nucleotides in target nucleic acid molecules. Thus, the invention relates to methods of sub-unit sequencing. The methods comprise the use of identification nucleic acid detection entities which specifically hybridize to the target nucleic acid, bind identification tags and have localization tags transiently bind thereto.