Abstract: The present invention relates to a cushion for preventing pressure sore. The cushion for preventing pressure sore includes an air cell layer, an air passage layer, a base layer, and a plurality of air ducts. The air cell layer has a plurality of air cells; the air cell layer is divided into at least four air cell zones. Air cells in each air cell zone are in communication with each other, but air cells in any two adjacent air cell zones are not in communication with each other; the air passage layer is under the air cell layer and has a plurality of air passages therein. Each air passage is in connection and communication with at least one of the air cell zones; the air passage layer and the air cell layer are disposed on the base layer; an end of each air duct is in communication with a corresponding air passage, and the other end extends out of the cushion and is provided with a joint; and each air duct has a respective valve.