Abstract: The present disclosure is concerned with N-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)benzamide compounds that are capable of inhibiting SPAK kinase function, methods of treating hypoxic brain injuries due to, for example, ischemic stroke. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Type:
Grant
Filed:
February 16, 2021
Date of Patent:
August 16, 2022
Assignees:
UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH OF HIGHER EDUCATION, XIAMAN UNIVERSITY, UNIVERSITY OF EXETER
Inventors:
Dandan Sun, Xianming Deng, Jinwei Zhang, Mohammad Iqbal Hossain Bhuiyan, Bradley J. Molyneaux