Abstract: The present disclosure pertains to the technical field of vitamin K2, and relates to a vitamin K2 microcapsule, a preparation method thereof, and use thereof in the manufacture of a medicament for preventing and treating cardiovascular and cerebrovascular diseases. The vitamin K2 microcapsule contains the following components by weight: 0.001 to 10 parts of vitamin K2, 5 to 30 parts of polyunsaturated fatty acid source, 0.1 to 10 parts of vitamin E-polyethylene glycol succinate, 50 to 95 parts of water-phase wall material and 0.01 to 10 parts of antioxidant, the polyunsaturated fatty acid source contains an ?-6 source and an ?-3 source, and the antioxidant is a water-phase antioxidant and/or an oil-phase antioxidant. The vitamin K2 microcapsule prepared by the method of the present disclosure has good water solubility, good stability and high bioavailability, can significantly improve the preventive and/or therapeutic effects on cardiovascular and cerebrovascular diseases, and has broad application prospects.

Abstract: The present invention pertains to the field of nutrition and medicine, and relates to a drug combination for anti-aging and its use. Specifically, the present invention relates to a drug combination comprising: 0.5 to 30 parts by weight of NR or its pharmaceutically acceptable salt, 0.5 to 30 parts by weight of NMN, and 0.01 to 35 parts by weight of mineral. The drug combination of the present invention has good anti-oxidative or anti-aging effects, and has excellent stability.

Abstract: The invention pertains to the field of food or medicine, and relates to a method for preparing modified starch, a liposome and a method for preparing liposome. Specifically, the method for preparing modified starch, comprises: (1) in a supercritical carbon dioxide medium, starch is used as raw material, ethanol is used as an entrainer, and the reaction is carried out under supercritical CO2 conditions to obtain a pretreated product; (2) separating and purifying the pretreated product of step (1); (3) using the pretreated product obtained in step (2) to prepare modified starch; and (4) separating and purifying the modified starch prepared in step (3). The liposome prepared from the modified starch of the present invention has good stability, encapsulation rate and bioavailability.

Abstract: The present disclosure provides a crystalline form of calcium D-glycerate of formula and a method for preparing the crystalline form of calcium D-glycerate of formula (I). The crystalline form may be characterized by having X-ray powder diffraction pattern (XRPD) diffraction peaks (2? degrees) at 12.9°±0.2°, 20.9°±0.2°, and 31.7°±0.2°.

Abstract: The present disclosure belongs to the technical field of coenzyme Q10, and relates to a coenzyme Q10 oiling agent, a preparation method and a use thereof. The coenzyme Q10 oiling agent comprises the following components in percentage by mass: 20-40% of coenzyme Q10, 45-65% of mixed oil, 10-15% of biphase emulsifying agent, wherein the coenzyme Q10 in the coenzyme Q10 oiling agent is present in a molecular form above 0° C.; the mixed oil simultaneously contains a saturated fatty acid (ester) and an unsaturated fatty acid (ester); the biphase emulsifying agent simultaneously contains a hydrophilic emulsifying agent and a lipophilic emulsifying agent. The coenzyme Q10 in the coenzyme Q10 oiling agent provided by the present disclosure still can be stably present in the molecular form at high content, and therefore has high bioavailability.

Abstract: Processes for producing reduced coenzyme Q10 (CoQ10) are provided. The processes may include preparing a reaction mixture, which includes oxidized CoQ10, a reductase, a supplement coenzyme, a coenzyme regeneration enzyme, and a substrate of the coenzyme regeneration enzyme, and providing a condition so that components of the reaction mixture react to produce the reduced CoQ10.

Abstract: A system and method for purifying coenzyme Q10 are provided. The method includes: passing a CoQ10-containing crude product through a first chromatographic column to obtain a first CoQ10-containing intermediate product. The method further includes preparing, based on the first CoQ10-containing intermediate product, a second CoQ10-containing intermediate product. The method further includes passing the second CoQ10-containing intermediate product through a second chromatographic column to obtain a third CoQ10-containing intermediate product. The method further includes obtaining purified CoQ10 product by purifying the third CoQ10-containing intermediate product.

Abstract: Controlled coenzyme Q10 (CoQ10) fermentation production processes and methods for controlling the CoQ10 fermentation production processes are provided in the present disclosure. The processes may include growing a microbial culture of bacteria by providing a carbon source and an oxygen source for a predetermined period of time, thereby producing CoQ10-containing bacteria, carbon dioxide, and lactate in the bacterial culture. During various stages of the production process, the concentration of carbon dioxide may be maintained at predetermined levels, respectively. Alternatively or additionally, during various stages of the production process, the concentration of lactate may be maintained at predetermined levels, respectively.

Abstract: Controlled coenzyme Q10 (CoQ10) fermentation production processes and methods for controlling the CoQ10 fermentation production processes are provided in the present disclosure. The processes may include growing a microbial culture of bacteria by providing a carbon source and an oxygen source for a predetermined period of time, thereby producing CoQ10-containing bacteria, carbon dioxide, and lactate in the bacterial culture. During various stages of the production process, the concentration of carbon dioxide may be maintained at predetermined levels, respectively. Alternatively or additionally, during various stages of the production process, the concentration of lactate may be maintained at predetermined levels, respectively.

Abstract: Controlled coenzyme Q10 (CoQ10) fermentation production processes and methods for controlling the CoQ10 fermentation production processes are provided in the present disclosure. The processes may include growing a microbial culture of bacteria by providing a carbon source and an oxygen source for a predetermined period of time, thereby producing CoQ10-containing bacteria, carbon dioxide, and lactate in the bacterial culture. During various stages of the production process, the concentration of carbon dioxide may be maintained at predetermined levels, respectively. Alternatively or additionally, during various stages of the production process, the concentration of lactate may be maintained at predetermined levels, respectively.

Abstract: The present invention relates to a composition for preventing and/or treating cardiovascular and cerebrovascular diseases, a method for preparing the same, and use thereof, wherein the composition comprises at least two of docosahexaenoic acid or an ester thereof, coenzyme Q10, lipoic acid and phospholipid. The composition is used for preparing a dietary supplement or health food, preferably, for preparing a dietary supplement or health food for preventing and/or treating dyslipidemia or cardiovascular and cerebrovascular diseases.

Abstract: Controlled coenzyme Q10 (CoQ10) fermentation production processes and methods for controlling the CoQ10 fermentation production processes are provided in the present disclosure. The processes may include growing a microbial culture of bacteria by providing a carbon source and an oxygen source for a predetermined period of time, thereby producing CoQ10-containing bacteria, carbon dioxide, and lactate in the bacterial culture. During various stages of the production process, the concentration of carbon dioxide may be maintained at predetermined levels, respectively. Alternatively or additionally, during various stages of the production process, the concentration of lactate may be maintained at predetermined levels, respectively.

Abstract: A system and method for purifying coenzyme Q10 are provided. The method includes: passing a CoQ10-containing crude product through a first chromatographic column to obtain a first CoQ10-containing intermediate product. The method further includes preparing, based on the first CoQ10-containing intermediate product, a second CoQ10-containing intermediate product. The method further includes passing the second CoQ10-containing intermediate product through a second chromatographic column to obtain a third CoQ10-containing intermediate product. The method further includes obtaining purified CoQ10 product by purifying the third CoQ10-containing intermediate product.

Abstract: The invention relates to a method for fermentation production of DHA, in particular a method for producing DHA through solid culture and liquid fermentation of Schizochytrium. The method comprises steps of activation of a strain, preparation of a suspension of the strain, preparation of a primary seed, preparation of a secondary solid seed, enlarging cultivation of the secondary solid seed in a fermentor, collection of cells after fermentation, and extraction of DHA oil. With the fermentation method, the seed preparation method is improved, the seed enlarging technology is simplified, the period of seed culture and fermentation is shortened, and therefore the investment is reduced and the cost is saved; in addition, the solid culture medium is of eutrophy and rich in a plurality of growth factors, and is more beneficial to the growth of the seed; cells are strong in viability and good in synchronism in solid culture medium.

Abstract: A fermentation method for producing coenzyme Q10 is provided, including stepwisly culturing of microbial strains capable of producing coenzyme Q10, wherein key promoting factors are added in each stage of culture, and in the stage of culture in a fermentor, dissolved oxygen feedback-fed batch culture technique is adopted to realize the feedback regulation of the production of coenzyme Q10, so as to improve the yield of coenzyme Q10.

Abstract: The invention relates to a method for fermentation production of DHA, in particular a method for producing DHA through solid culture and liquid fermentation of Schizochytrium. The method comprises steps of activation of a strain, preparation of a suspension of the strain, preparation of a primary seed, preparation of a secondary solid seed, enlarging cultivation of the secondary solid seed in a fermentor, collection of cells after fermentation, and extraction of DHA oil. With the fermentation method, the seed preparation method is improved, the seed enlarging technology is simplified, the period of seed culture and fermentation is shortened, and therefore the investment is reduced and the cost is saved; in addition, the solid culture medium is of eutrophy and rich in a plurality of growth factors, and is more beneficial to the growth of the seed; cells are strong in viability and good in synchronism in solid culture medium.

Abstract: A method for producing coenzyme Q10 by using stock culture from solid phase fermentation. The strain used in this method is Rhodobacter sphaeroides. Strain passaging is carried out by culturing in a slant medium. After steam cooking and air drying, solid medium is subpackaged and sterilized, wherein said solid medium includes solid components and liquid components. The fresh culture of Rhodobacter sphaeroides on the slant medium is added with sterile water, and the resultant bacterial suspension is added into the solid medium, cultured and used as stock culture for primary fermentation. The method of the present invention can enhance the fermentation level of coenzyme Q10, reduce the cascades of fermentation, shorten production cycle, simplify production processes, and lower production cost.

Abstract: A method for producing coenzyme Q10 by using stock culture from solid phase fermentation. The strain used in this method is Rhodobacter sphaeroides. Strain passaging is carried out by culturing in a slant medium. After steam cooking and air drying, solid medium is subpackaged and sterilized, wherein said solid medium includes solid components and liquid components. The fresh culture of Rhodobacter sphaeroides on the slant medium is added with sterile water, and the resultant bacterial suspension is added into the solid medium, cultured and used as stock culture for primary fermentation. The method of the present invention can enhance the fermentation level of coenzyme Q10, reduce the cascades of fermentation, shorten production cycle, simplify production processes, and lower production cost.

Abstract: A fermentation method for producing coenzyme Q10 is provided, including stepwisly culturing of microbial strains capable of producing coenzyme Q10, wherein key promoting factors are added in each stage of culture, and in the stage of culture in a fermentor, dissolved oxygen feedback-fed batch culture technique is adopted to realize the feedback regulation of the production of coenzyme Q10, so as to improve the yield of coenzyme Q10.