Patents Assigned to XIAMEN SINOPEG BIOTECH CO., LTD.
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Patent number: 11324827Abstract: Disclosed are a multifunctionalized polyethylene glycol derivative and a preparation method therefor. The derivative has an H-shaped structure as represented by formula (1) and comprises one linear core LPEG and four PEG branch chains, where n1, n2, n3, and n4 respectively are the degrees of polymerization of the branch chains, U1 and U2 are trivalent branching groups connecting the core LPEG to two of the PEG branch chains, F1 and F2 contain a functional group or a protected form R01 thereof and may or may not contain a branched group G, correspondingly, the number of R01 is one or more, F1 and F2 are either identical or different, any one linking group in the molecule or any linking group formed with an adjacent heteroatom group can either remain stable or be degraded, and any one PEG segment in the molecule is discretely polydispersed or monodispersed.Type: GrantFiled: September 30, 2015Date of Patent: May 10, 2022Assignee: Xiamen Sinopeg Biotech Co., Ltd.Inventors: Wengui Weng, Chao Liu, Ce Yan, Shaofeng Wu, Chun Zhou
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Publication number: 20220118100Abstract: The monofunctional branched poly(ethylene glycol) (PEG) has a general formula shown in formula (1), and the bio-related substance modified by the monofunctional branched PEG has a general formula shown in formula (2), wherein X1 and X2 are each independently a hydrocarbon group having 1 to 20 carbon atoms, n1 and n2 are each independently an integer selected from 1 to 1000, n3 is an integer selected from 11 to 1000, L1, L2 are each independently a linking group, p is 0 or 1, q is 0 or 1, R1 is a hydrogen atom or a hydrocarbon group having 1 to 20 carbon atoms, D is a bio-related substance, Z is a linking group, and Z can react with the bio-related substance to form a residue group L3. The PEG-modified bio-related substance maintains good biological activity, and has better solubility and a longer half-life in vivo.Type: ApplicationFiled: December 23, 2021Publication date: April 21, 2022Applicant: Xiamen Sinopeg Biotech Co., Ltd.Inventors: WenGui WENG, Chao LIU, JinCheng LIAO, JinChun YUAN
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Patent number: 10660969Abstract: Disclosed are an 8-arm polyethylene glycol (PEG) derivative (formula 1), manufacturing method and modified bio-related substance thereby, wherein a tetravalent group U and four trivalent groups Ec form a highly symmetric octavalent central structure CORE0 together, Lc connects the octavalent center to eight PEG arms having polydiversity or monodiversity and having n1-n8 as the degrees of polymerization thereof. The terminal of one PEG chain is connected to at least one functional group F (k?1), and said PEG chain and F can be directly connected (g=0) or connected with a divalent linking group L0 connected with a terminal branched group G (g=1) therebetween. The latter provides more reacting sites to combine more pharmaceutical molecules, thereby increasing the drug loading capacity.Type: GrantFiled: July 31, 2019Date of Patent: May 26, 2020Assignee: Xiamen Sinopeg Biotech Co., Ltd.Inventors: Wengui Weng, Chao Liu, Ce Yan, Huihuang Su, Chun Zhou
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Publication number: 20190365910Abstract: Disclosed are an 8-arm polyethylene glycol (PEG) derivative (formula 1), manufacturing method and modified bio-related substance thereby, wherein a tetravalent group U and four trivalent groups Ec form a highly symmetric octavalent central structure CORE0 together, Lc connects the octavalent center to eight PEG arms having polydiversity or monodiversity and having n1-n8 as the degrees of polymerization thereof. The terminal of one PEG chain is connected to at least one functional group F (k?1), and said PEG chain and F can be directly connected (g=0) or connected with a divalent linking group L0 connected with a terminal branched group G (g=1) therebetween. The latter provides more reacting sites to combine more pharmaceutical molecules, thereby increasing the drug loading capacity.Type: ApplicationFiled: July 31, 2019Publication date: December 5, 2019Applicant: Xiamen Sinopeg Biotech Co., Ltd.Inventors: Wengui Weng, Chao Liu, Ce Yan, Huihuang Su, Chun Zhou
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Patent number: 10434182Abstract: Disclosed are an eight-arm polyethylene glycol (PEG) derivative (formula I), production method therefor and modified bio-related substance thereby. Wherein, one tetravalent group U together with four trivalent groups Ec form a highly symmetrical octavalent group CORE0; Lc connects the octavalent group to eight PEG chains having polydispersity or monodispersity and having n1 to n8 as the degree of polymerization thereof; the terminal of one PEG chain is connected to at least one functional group F (k?1); said PEG chain and F therebetween can be directly connected (g=0) or be indirectly connected via a linking group L0 to a terminal end-branching group G (g=1); the latter provides more reactive sites for binding more drug molecules and increases the drug loading.Type: GrantFiled: June 8, 2016Date of Patent: October 8, 2019Assignee: Xiamen Sinopeg Biotech Co., Ltd.Inventors: Wengui Weng, Chao Liu, Ce Yan, Huihuang Su, Chun Zhou
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Publication number: 20180214561Abstract: Disclosed are an eight-arm polyethylene glycol (PEG) derivative (formula I), production method therefor and modified bio-related substance thereby. Wherein, one tetravalent group U together with four trivalent groups Ec form a highly symmetrical octavalent group CORE0; Lc connects the octavalent group to eight PEG chains having polydispersity or monodispersity and having n1 to n8 as the degree of polymerization thereof; the terminal of one PEG chain is connected to at least one functional group F (k?1); said PEG chain and F therebetween can be directly connected (g=0) or be indirectly connected via a linking group L0 to a terminal end-branching group G (g=1); the latter provides more reactive sites for binding more drug molecules and increases the drug loading.Type: ApplicationFiled: June 8, 2016Publication date: August 2, 2018Applicant: XIAMEN SINOPEG BIOTECH CO., LTD.Inventors: Wengui WENG, Chao LIU, Ce YAN, Huihuang SU, Chun ZHOU
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Publication number: 20170312363Abstract: Disclosed are a multifunctionalized polyethylene glycol derivative and a preparation method therefor. The derivative has an H-shaped structure as represented by formula (1) and comprises one linear core LPEG and four PEG branch chains, where n1, n2, n3, and n4 respectively are the degrees of polymerization of the branch chains, U1 and U2 are trivalent branching groups connecting the core LPEG to two of the PEG branch chains, F1 and F2 contain a functional group or a protected form R01 thereof and may or may not contain a branched group G, correspondingly, the number of R01 is one or more, F1 and F2 are either identical or different, any one linking group in the molecule or any linking group formed with an adjacent heteroatom group can either remain stable or be degraded, and any one PEG segment in the molecule is discretely polydispersed or monodispersed.Type: ApplicationFiled: September 30, 2015Publication date: November 2, 2017Applicant: XIAMEN SINOPEG BIOTECH CO., LTD.Inventors: Wengui WENG, Chao LIU, Ce YAN, Shaofeng WU, Chun ZHOU