Abstract: This invention discloses novel quinolonecarboxylic acid derivatives, pharmaceutically acceptable salts or hydrates thereof, and their preparation methods and medical uses. The compounds in this invention show potent antibacterial activity against broad-spectrum pathogenic bacteria, with favorable pharmacokinetics and very low toxicity. The quinolinecarboxylic acid derivatives, which possess a hydrogen atom or an amino group at C-5 position, cis-substituted optical or racemic 2,8-diazo-dicyclo[4,3,0]nonanyl at C-7 position, and difluoromethoxyl at C-8 position of quinolone core, have superior activity against gram-positive bacteria and broad spectrum antibacterial activity compared with the known quinolones.
Type:
Grant
Filed:
April 13, 2005
Date of Patent:
July 20, 2010
Assignees:
Institut of Medicinal Biotechnology Chinese Academy of Medical Sciences, Xinchang Pharmaceutical Factory, Zhejiang Medicine Co. Ltd.
Abstract: This invention has disclosed a method for preparation of food-grade zeaxanthin through chemical isomerizaton reaction from lutein. The technical issues to be solved in this invention are quite low product yield obtained with existing methods, need of purification treatment process, and inadaptability to industrialized production. The technical schemes of this invention are: a. Mix xanthophyll crystal or its fatty acid ester with food-grade glycol or propylene glycol, for full dissolution under 60-90° C. temperature. Add organic alkali into the mixed liquor acquired from step 1, for isomerization reaction to take place under inertial environment. c. Dilute the reaction solution gained from step b with the mixed solution of deionized water and ethanol, and separate the obtained crystal with conventional separating method. d. Vacuum dries the acquired crystal from step c, to get the zeaxanthin crystal.
Type:
Grant
Filed:
September 18, 2007
Date of Patent:
February 3, 2009
Assignee:
Zhejiang Medicine Co., Ltd., XinChang Pharmaceutical Factory
Inventors:
Xinde Xu, Lihua Zhang, Boqiu Chen, Di Zhou, Shuangming Ye, Chiyu Ding, Hongping Lv, Bin Shao
Abstract: This invention has disclosed a method for preparation of food-grade zeaxanthin through chemical isomerizaton reaction from lutein. The technical issues to be solved in this invention are quite low product yield obtained with existing methods, need of purification treatment process, and inadaptability to industrialized production. The technical schemes of this invention are: a. Mix xanthophyll crystal or its fatty acid ester with food-grade glycol or propylene glycol, for full dissolution under 60-90° C. temperature. Add organic alkali into the mixed liquor acquired from step 1, for isomerization reaction to take place under inertial environment. c. Dilute the reaction solution gained from step b with the mixed solution of deionized water and ethanol, and separate the obtained crystal with conventional separating method. d. Vacuum dries the acquired crystal from step c, to get the zeaxanthin crystal.
Type:
Application
Filed:
September 18, 2007
Publication date:
April 3, 2008
Applicants:
Zhejiang Medicine Co., Ltd., Xinchang Pharmaceutical Factory
Inventors:
Xinde Xu, Lihua Zhang, Boqiu Chen, Di Zhou, Shuangming Ye, Chiyu Ding, Hongping Lv, Bin Shao
Abstract: 1-Chloro-2-methyl-4-acyloxy-2-butene derivatives can be synthesized in good yields and high purity starting from isoprene and employing a chlorohydrin formation reaction in a system made of N-chloroisocyanuric acid derivatives and water, followed by esterification and rearrangement of the crude product mixture.
Type:
Grant
Filed:
May 17, 2007
Date of Patent:
April 1, 2008
Assignees:
Shaoxing University, Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
Inventors:
Runpu Shen, Guoqi Yu, Weidong Ye, Kui Wang, Xuejun Lao
Abstract: 1-Chloro-2-methyl-4-acyloxy-2-butene derivatives can be synthesized in good yields and high purity starting from isoprene and employing a chlorohydrin formation reaction in a system made of N-chloroisocyanuric acid derivatives and water, followed by esterification and rearrangement of the crude product mixture.
Type:
Application
Filed:
May 17, 2007
Publication date:
November 22, 2007
Applicants:
SHAOXING UNIVERSITY, ZHEJIANG MEDICINE CO., LTD., XINCHANG PHARMACEUTICAL FACTORY
Inventors:
Runpu SHEN, Guoqi YU, Weidong YE, Kui WANG, Xuejun LAO
Abstract: The invention relates to the field of microbial technology. It discloses a method to apply the cloud point system (CPS) in biotransformation by selecting one or more types of nonionic surfactant to form a aqueous system with a cloud point below the microbial transformation temperature, which serves as transformation medium. The method disclosed is suitable in particular for microbial transformation of hydrophobic compounds, for the system where substrate or product inhibits microbial growth or where product is further degraded by microbes. The CPS in the present invention forms a microemulsion of water-in-oil and oil-in-water, where the drops of surfactant is able to solubilize, serving as substrate reservoir and product extractant. This enhances bioavailability of substrates and elimination of product inhibition.
Type:
Application
Filed:
July 5, 2004
Publication date:
November 8, 2007
Applicants:
Shanghai Health Creation Center for Biopharmaceutical R&D Co., LTD., Zhejiang Medicine Co., LTD. Xinchang Pharmaceutical Factory
Inventors:
Daijie Chen, Zhilong Wang, Mei Ge, Yiping Jin, Weidong Ye
Abstract: A process for isolation and purification of xanthophylls crystals from plant oleoresin is disclosed. The organic solvents involved in the process is no other than food grade alcohol. The process includes saponifying the plant oleoresin containing xanthophyll diesters, neutralizing the saponified reaction mixture with an acid and washing water-soluble impurities and other fat-soluble oil with warm water and alcohol, respectively. The process can improve purity and yield of products, by which the content and the recovery of xanthophylls are as high as 90% and 80% respectively. And the process is economical and easy to perform in industrial production.
Type:
Grant
Filed:
January 23, 2006
Date of Patent:
September 18, 2007
Assignee:
Zhe Jiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
Inventors:
Xinde Xu, Bin Shao, Di Zhou, Shuangming Ye, Yanfeng Wang, Boqiu Chen
Abstract: A process for isolation and purification of xanthophylls crystals from plant oleoresin is disclosed. The organic solvents involved in the process is no other than food grade alcohol. The process includes saponifying the plant oleoresin containing xanthophyll diesters, neutralizing the saponified reaction mixture with an acid and washing water-soluble impurities and other fat-soluble oil with warm water and alcohol, respectively. The process can improve purity and yield of products, by which the content and the recovery of xanthophylls are as high as 90% and 80% respectively. And the process is economical and easy to perform in industrial production.
Type:
Application
Filed:
January 23, 2006
Publication date:
February 8, 2007
Applicant:
Zhe Jiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
Inventors:
Xinde Xu, Bin Shao, Di Zhou, Shuangming Ye, Yanfeng Wang, Boqiu Chen
Abstract: The invention relates to a process for producing all trans-vitamin A ester (I). According to the present invention, vitamin A ester (I) can simply be synthesized in good yields and high purity by the reaction of phosphonate compound (IV) with aldehyde (II) in an organic solvent in the presence of a base.
Type:
Grant
Filed:
January 3, 2002
Date of Patent:
April 27, 2004
Assignee:
Zhejiang Medicine Co., Ltd., Xinchang Pharmaceutical
Factory
Inventors:
Runpu Shen, Shiqing Pi, Bin Xie, Hongjun Huang