Abstract: A preparation method of drug-loaded micelles of an absorbable vascular stent coating for angiostenosis in an infant is provided, including the following steps: S1: dissolving a drug to be encapsulated in an appropriate amount of an emulsifying agent, adding a chitosan-poly(p-dioxohone) amphiphilic block copolymer (chitosan-b-PPDO copolymer), and thoroughly mixing to obtain a drug-copolymer solution; S2: adding the drug-copolymer solution obtained in S1 dropwise to an emulsifying agent aqueous solution prepared in advance, and continuously stirring to obtain a stable drug-loaded micellar solution; and S3: removing the emulsifying agent from the micellar solution obtained in S2 through vacuum evaporation, stirring a resulting concentrate, and centrifuging the concentrate to obtain a supernatant; and filtering the supernatant to obtain a filtrate, and subjecting the filtrate to dialysis to obtain the drug-loaded micelles.
Type:
Grant
Filed:
March 29, 2022
Date of Patent:
May 21, 2024
Assignee:
XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE
Inventors:
Kun Sun, Jing Sun, Sun Chen, Kai Bai, Yanan Lu, Lu Wang, Fujun Wang, Fan Zhao, Jihong Huang
Abstract: A preparation method of drug-loaded micelles of an absorbable vascular stent coating for angiostenosis in an infant is provided, including the following steps: Si: dissolving a drug to be encapsulated in an appropriate amount of an emulsifying agent, adding a chitosan-poly(p-dioxohone) amphiphilic block copolymer (chitosan-b-PPDO copolymer), and thoroughly mixing to obtain a drug-copolymer solution; S2: adding the drug-copolymer solution obtained in S1 dropwise to an emulsifying agent aqueous solution prepared in advance, and continuously stirring to obtain a stable drug-loaded micellar solution; and S3: removing the emulsifying agent from the micellar solution obtained in S2 through vacuum evaporation, stirring a resulting concentrate, and centrifuging the concentrate to obtain a supernatant; and filtering the supernatant to obtain a filtrate, and subjecting the filtrate to dialysis to obtain the drug-loaded micelles.
Type:
Application
Filed:
March 29, 2022
Publication date:
February 8, 2024
Applicant:
XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE
Inventors:
Kun SUN, Jing SUN, Sun CHEN, Kai BAI, Yanan LU, Lu WANG, Fujun WANG, Fan ZHAO, Jihong HUANG
Abstract: A steel plate for funnel chest orthopaedic surgery includes a supporting plate (1), a fixing piece (2), a telescopic fixing piece (3), a guiding head (4) and screws (6). The supporting plate (1) is an elongate steel plate. One end of the supporting plate (1) is designed to be integrated with the fixing piece (2), and the other end is provided with a size-adjusting strap (5). The telescopic fixing piece (3) is an elongate steel plate with the same width as that of the supporting plate (1). One end of the telescopic fixing piece (3) is designed to be integrated with the fixing piece (2), and the other end is provided with a groove. The guiding head (4) is an elongate steel plate with the same width as that of the supporting plate (1). One end of the guiding head (4) is provided with a hook, and the other end is provided with a groove.
Type:
Grant
Filed:
May 26, 2010
Date of Patent:
November 4, 2014
Assignee:
Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Abstract: A steel plate for funnel chest orthopaedic surgery includes a supporting plate (1), a fixing piece (2), a telescopic fixing piece (3), a guiding head (4) and screws (6). The supporting plate (1) is an elongate steel plate. One end of the supporting plate (1) is designed to be integrated with the fixing piece (2), and the other end is provided with a size-adjusting strap (5). The telescopic fixing piece (3) is an elongate steel plate with the same width as that of the supporting plate (1). One end of the telescopic fixing piece (3) is designed to be integrated with the fixing piece (2), and the other end is provided with a groove. The guiding head (4) is an elongate steel plate with the same width as that of the supporting plate (1). One end of the guiding head (4) is provided with a hook, and the other end is provided with a groove.
Type:
Application
Filed:
May 26, 2010
Publication date:
May 24, 2012
Applicant:
XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE