Patents Assigned to XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE
  • Patent number: 11986575
    Abstract: A preparation method of drug-loaded micelles of an absorbable vascular stent coating for angiostenosis in an infant is provided, including the following steps: S1: dissolving a drug to be encapsulated in an appropriate amount of an emulsifying agent, adding a chitosan-poly(p-dioxohone) amphiphilic block copolymer (chitosan-b-PPDO copolymer), and thoroughly mixing to obtain a drug-copolymer solution; S2: adding the drug-copolymer solution obtained in S1 dropwise to an emulsifying agent aqueous solution prepared in advance, and continuously stirring to obtain a stable drug-loaded micellar solution; and S3: removing the emulsifying agent from the micellar solution obtained in S2 through vacuum evaporation, stirring a resulting concentrate, and centrifuging the concentrate to obtain a supernatant; and filtering the supernatant to obtain a filtrate, and subjecting the filtrate to dialysis to obtain the drug-loaded micelles.
    Type: Grant
    Filed: March 29, 2022
    Date of Patent: May 21, 2024
    Assignee: XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Kun Sun, Jing Sun, Sun Chen, Kai Bai, Yanan Lu, Lu Wang, Fujun Wang, Fan Zhao, Jihong Huang
  • Publication number: 20240042109
    Abstract: A preparation method of drug-loaded micelles of an absorbable vascular stent coating for angiostenosis in an infant is provided, including the following steps: Si: dissolving a drug to be encapsulated in an appropriate amount of an emulsifying agent, adding a chitosan-poly(p-dioxohone) amphiphilic block copolymer (chitosan-b-PPDO copolymer), and thoroughly mixing to obtain a drug-copolymer solution; S2: adding the drug-copolymer solution obtained in S1 dropwise to an emulsifying agent aqueous solution prepared in advance, and continuously stirring to obtain a stable drug-loaded micellar solution; and S3: removing the emulsifying agent from the micellar solution obtained in S2 through vacuum evaporation, stirring a resulting concentrate, and centrifuging the concentrate to obtain a supernatant; and filtering the supernatant to obtain a filtrate, and subjecting the filtrate to dialysis to obtain the drug-loaded micelles.
    Type: Application
    Filed: March 29, 2022
    Publication date: February 8, 2024
    Applicant: XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Kun SUN, Jing SUN, Sun CHEN, Kai BAI, Yanan LU, Lu WANG, Fujun WANG, Fan ZHAO, Jihong HUANG
  • Patent number: 8876823
    Abstract: A steel plate for funnel chest orthopaedic surgery includes a supporting plate (1), a fixing piece (2), a telescopic fixing piece (3), a guiding head (4) and screws (6). The supporting plate (1) is an elongate steel plate. One end of the supporting plate (1) is designed to be integrated with the fixing piece (2), and the other end is provided with a size-adjusting strap (5). The telescopic fixing piece (3) is an elongate steel plate with the same width as that of the supporting plate (1). One end of the telescopic fixing piece (3) is designed to be integrated with the fixing piece (2), and the other end is provided with a groove. The guiding head (4) is an elongate steel plate with the same width as that of the supporting plate (1). One end of the guiding head (4) is provided with a hook, and the other end is provided with a groove.
    Type: Grant
    Filed: May 26, 2010
    Date of Patent: November 4, 2014
    Assignee: Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine
    Inventors: Guoqing Li, Ju Mei, Deyu Zhu
  • Publication number: 20120130371
    Abstract: A steel plate for funnel chest orthopaedic surgery includes a supporting plate (1), a fixing piece (2), a telescopic fixing piece (3), a guiding head (4) and screws (6). The supporting plate (1) is an elongate steel plate. One end of the supporting plate (1) is designed to be integrated with the fixing piece (2), and the other end is provided with a size-adjusting strap (5). The telescopic fixing piece (3) is an elongate steel plate with the same width as that of the supporting plate (1). One end of the telescopic fixing piece (3) is designed to be integrated with the fixing piece (2), and the other end is provided with a groove. The guiding head (4) is an elongate steel plate with the same width as that of the supporting plate (1). One end of the guiding head (4) is provided with a hook, and the other end is provided with a groove.
    Type: Application
    Filed: May 26, 2010
    Publication date: May 24, 2012
    Applicant: XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Guoqing Li, Ju Mei, Deyu Zhu