Abstract: Technologies are described to control and optimize a delivery timing and dosage of agents, such as nootropics, in an individually tailored manner. Nootropics enhance cognitive functions, including executive functions, memory, creativity and/or motivation. Typically, nootropic regimes require a person to orally take multiple different agents at different dosages and at different times of the day. Embodiments are directed to instructing a delivery device to deliver an agent at a predefined time and dosage to an individual, receiving an input associated with parameters related to a physiological function and/or a cognitive function of the individual, and processing the input to analyze an efficacy of the agent. The predefined time and/or dosage for delivery of the agent to the individual may then be adjusted based on the analysis. The delivery device may be a standalone device or may be integrated with various other items.

Abstract: Technologies are described image a treatment area during laser treatment using a time-gated image capture device and an electronic display. During laser treatment, a physician may monitor a treatment area to ensure efficacy and to prevent over-treatment. Light reflected from the area that includes treatment area may be detected by an image capture component and converted to a signal. An image processor may then generate image data based on the signal and provide the image data to be displayed on an electronic device. A gating component may send instructions to the image capture component and/or the image processor to prevent inclusion of light from one or more laser pulses generated during treatment. Excluding light from the laser pulses may prevent glare in captured images allow a monitoring physician to safely and accurately monitor the treatment area.

Abstract: Technologies are described for detection of eye surface vibrations to determine cell damage within a treatment area of an eye undergoing laser treatment. Eye surface vibrations may be caused by intraocular pressure waves that form during the laser treatment. For example, the pressure waves may originate from a plurality of bubbles forming and/or rupturing inside cells located in the treatment area. The bubbles may form as energy from a treatment laser beam is absorbed by the retinal tissue. The pressure waves may be measured at the surface of the eye through Doppler vibrometry to determine if the cells within the treatment area have been damaged. The damage to the cells may include cell lysis, a rupture of cell membranes, scarring, and/or photocoagulation, among other examples.

Abstract: Technologies are described for delivery of compounds to aid in weight management. A transdermal microdispenser based system may deliver weight management compounds through the time and dose specific administration of appetite suppression, metabolic enhancers, and satiation compounds. The transdermal delivery system may be controlled based on data associated with subject such as calorie intake, physical activity, satiation, and hunger. The system may be integrated with medical monitoring or fitness tracking systems. Delivery of the compounds may be distributed over the course of a day at selected or adjusted doses to be safe and effective for their specific modality. For example, appetite suppressants may be delivered during periods of the day when cravings occur, satiation compounds may be delivered to coincide with meals, and metabolic stimulators may be delivered at times to optimally increase metabolism based on caloric balance. Control factors may also be predictive to prevent the onset of hunger.

Abstract: Technologies are described for visualization of current and predicted crowd behavior information for surveillance. In surveillance systems, a variety of image capture devices and audio capture devices may be positioned strategically throughout a building or an area. The capture devices may transmit respective audio and video signals to a display device, such as a monitor in a surveillance control room, and to a signal processor for crowd behavior analysis. A signal processor, according to some examples, may receive crowd characteristics for an area, derive current crowd behavior information from the crowd characteristics, and predict crowd behavior information based on crowd characteristics, area characteristics, normalized crowd behavior information (from other areas), and/or external information. The signal processor may provide current and predicted crowd behavior information to a display device.

Abstract: Technologies are generally described for object trajectory augmentation on a newly displayed video stream in surveillance environments. A surveillance system may derive and store motion vectors associated with multiple targets in videos captured in a surveillance environment. In some examples, the motion vectors may be derived through parsing of the captured videos without complete decoding. Upon selection of a particular video for display, one or more targets in the current video may be identified and their motion vectors derived. A trajectory of the target(s) may then be generated based on a match of motion vectors from the current video and stored motion vectors. The generated trajectory may be used to augment the current video providing an observer a past and/or future path for the identified target(s).

Abstract: Technologies are generally described for replayable hacktraps for intruder capture with reduced impact on false positives. An example system may generate a replayable set of actions such as scripts and/or file system differences upon detecting the actions being forwarded to a deception network as potentially malicious actions. If the actions are determined not to be malicious, they may be executed on the protected network. Retroactively executing sequestered actions may allow deception countermeasures to be made more aggressive because false positive detections may have fewer negative impacts.

Abstract: A contact assembly (301,400) for laser surgery may include a contact lens (402) and an optical filter (404). The contact lens (402) may be configured to be positioned in an optical path of therapeutic radiation (310) directed at an eye (100) of a patient. The optical filter (404) may be coupled to an outer surface (402A) of the contact lens (402). The optical filter (404) may be transparent to the therapeutic radiation (310) with a first wavelength and may be opaque to radiation (318) with a second wavelength different than the first wavelength.

Abstract: An optical device can include: an incident light polarizer positioned to receive incident light and configured to polarize incident light such that polarized incident light is directed to a cornea of a subject; at least one corneal light polarizer, wherein the at least one corneal light polarizer is positioned to receive reflected light from the cornea of the subject and polarize the reflected light to a second polarization; at least one rotating mechanism; and at least one receiver. The receiver can be at least one viewing port optically coupled with the at least one corneal light polarizer or an imaging device (e.g., optical detector). The at least one rotating mechanism is: coupled with the incident light polarizer; coupled with the at least one corneal light polarizer; or coupled with the incident light polarizer and the at least one corneal light polarizer.

Abstract: A method of macular disease treatment (500) may include introducing nanocapsules into a body of a patient (502). The nanocapsules may be introduced such that the nanocapsules circulate through at least a portion of a body of the patient. A therapeutic substance and a colorant may be encapsulated into the nanocapsules. After a portion of the nanocapsules enters choroidal neovessels of an eye of the patient, the method may include emitting a pulsed laser radiation through a pupil of the eye (504). Additionally, after a portion of the nanocapsules enters choroidal neovessels of an eye of the patient, the method may include heating the portion of the nanocapsules present in the eye (506) such that at least a portion of the nanocapsules transfer phase and release the therapeutic substance.

Abstract: a laser-based ophthalmological treatment system(200) may include a device housing(202), a head fixation assembly(206), and an interactive display device(324, 424). The head fixation assembly(206) may be configured to position and to retain a head of a patient relative to the device housing(202). The interactive display device(324,424) may be positioned in an optical path(304,404). The interactive display device(324,424) may be fixed relative to the head fixation assembly(206). The interactive display device(324,424) may be configured to display a simulation scene(504) that may include a target image(502) into a visual field of the patient. The target image(502) may be displayed in the simulation scene(504) such that optical focus on the target image(502) by the patient aligns a portion of a fundus(130) of an eye of the patient in the optical path(304,404).

Abstract: A lens/sensor subassembly (318) may include a feedback sensor (324), a data transmission line (302), and an electrical element (328). The feedback sensor (324) may be configured to measure a phenomenon in an eye (100) of a patient during a laser-based ophthalmological therapy. The data transmission line (302) may be configured to communicate feedback data measured by the feedback sensor (324) to a laser-based ophthalmological treatment system (200). The electrical element (328) may be degradable in response to exposure to therapeutic radiation (316). The degradation of the electrical element (328) may interrupt communication of the feedback data measured by the feedback sensor (324) to the laser-based ophthalmological treatment system (200).

Abstract: Technologies are generally described for normalized standard deviation transition based dosimetry monitoring for laser treatment. In some examples, a response signal may be generated based on a physical response to a laser pulse detected through acoustic or optical means. Each response signal may be a time series of data with a number of points. Standard deviation may be determined for each response signal and normalized using a mean or comparable normalization factor. Thus, a robust distribution may be computed from the response to each laser pulse. A change in the normalized standard deviation from each single pulse's time domain response data may be used to determine how many laser pulses remain before completion of the treatment (similar to event onset response). Thus, laser treatment may be continued based on an estimation of remaining pulses for completion or ceased if completion is reached.

Abstract: Technologies are provided for context-based instruction delivery to field agents. In some examples, one or more context-sensitive criteria may be extracted from an instruction contained in a message. The message and the criteria may then be transmitted to multiple field agent devices. In response to receiving the message and the criteria, a field agent device may determine whether a legitimate agent is present and the criteria are satisfied. If a legitimate agent is present and the criteria are satisfied, then the agent device may provide the instruction in the message to the legitimate agent. On the other hand, if a legitimate agent is not present, or if the device and/or agent fail the criteria, then the device may ignore the instruction.

Abstract: Technologies are described for monitoring efficacy of laser treatment through cell lysis determination. Current methods for removing diseased tissue may include directing laser treatment toward cells in a treatment area. The laser treatment may induce lysis of the cells without any visual indication of the lysis occurring. According to some examples, a treatment system may direct a pair of laser pulses to cells in a treatment area. The treatment system may derive a first signal and a second signal based on a detected response to the first and second laser pulse within the pair. A signal processor, according to some examples, may determine a difference between the first signal and the second signal and may modify the laser treatment based on the difference.

Abstract: Technologies are described for visualization of an audio signal with a corresponding video signal for surveillance. An audio capture device may be configured in a surveillance area to capture an audio signal. One or more image capture devices may be configured to capture a video signal in the surveillance area. The audio capture device and the image capture device may be integrated into a capture device in some examples. The audio capture device and the image capture device may be configured to transmit the audio signal and the video signal to a signal processor, which may be configured to match the audio signal with a corresponding video signal, analyze the audio signal to extract information associated with surveillance, and overlay the corresponding video signal with the extracted information from the audio signal.

Abstract: Technologies are provided for laser treatment with reduced illumination variability. In some examples, a laser beam that creates a first illumination variation at a target site may be adjusted such that the laser beam orientation changes slightly while the laser beam is still being generated. The adjusted laser beam may create a second illumination variation at the target site, and because the laser beam orientation is different the first and second illumination variations may combine to form a combined illumination variation at the target site whose variability is less than the variability of the first or second illumination variations. The more-uniform combined illumination variation may then be used to treat the target site, for example via heat generation.

Abstract: Technologies are generally described for adjustment of displayed content based on recognition of viewer. In some examples, content that may include data, as well as, control elements associated with functionality of a surveillance system. The content may be displayed to a viewer based on the viewer's credentials. Responsive to detection of another viewer, the displayed content may be modified based on credentials of the other viewer. Viewers may be detected through a variety of techniques and displayed content may be associated with different authority levels. In other examples, content may be blocked from display if a viewer in a restricted list is detected in view of a display device.

Abstract: Technologies are generally described for customization of treatment based on dosimetric data collected during the treatment. In some examples, a laser treatment procedure may involve the application of multiple laser pulses to a treatment site. During the laser treatment procedure, an effect resulting from the application of one or more of the laser pulses may result in dosimetric data, such as acoustic and/or optical data. The dosimetric data may then be used to determine the efficacy of the laser treatment procedure and/or to adjust, in real-time, a remainder of the laser treatment procedure.

Abstract: A dosimetry system may comprise a film stack and a laser system for applying a laser beam to the film stack. The system may further comprise an interferometry system configured to acquire from the film stack a first interferometric dataset comprising a first composite signal and a subsequent interferometric dataset comprising a subsequent composite signal. The system may also include a processor for comparing the first and subsequent composite signals, wherein a difference between the first and subsequent composite signals indicates a change in the film stack thickness. A dosimetry method may comprise applying a laser beam to such a film stack, acquiring the first and subsequent interferometric datasets, comparing them to detect a change in the film stack thickness, and ceasing to apply the laser beam to the film stack if the change in the film stack thickness exceeds a predetermined threshold.