Abstract: An optical quantitative detection device comprising: an optical quantitative detection device comprising: a nonlinear/birefringent waveguide sensor with a top surface for interacting with a target molecule, wherein optical excitation of the sensor enables quantitative, spectral discrimination of the target molecule.
Type:
Grant
Filed:
August 27, 2002
Date of Patent:
December 21, 2004
Assignee:
Xoetronics, LLC
Inventors:
Nikolaus Dietz, Frank L. Madarasz, David Peter Krivoshik
Abstract: An opto-electronic device utilizes a band of partially polarized polychromatic light for quantitative analysis of a specimen containing a target molecule. The device comprises: a polarizer for producing a segmented band of partially polarized polychromatic light from the band of partially polarized polychromatic light; a specimen cell adapted for receiving the specimen and for transporting said segmented band of partially polarized polychromatic light to the specimen; a polarizing analyzer optically coupled to said segmented band of partially polarized polychromatic light exiting the specimen; and comparison means for comparing said segmented band of partially polarized polychromatic light before entering the specimen with said segmented band of partially polarized polychromatic light after exiting the specimen. The target molecule changes ellipticity of said segmented band of partially polarized polychromatic light and said polarizer is synchronized with said polarizing analyzer.
Type:
Grant
Filed:
February 17, 2000
Date of Patent:
October 21, 2003
Assignee:
Xoetronics LLC
Inventors:
Frank Madarasz, Darell Engelhaupt, James Wyly, Joseph Milelli, Ramarao Inguva
Abstract: An opto-electronic device utilizes a band of polychromatic light for quantitative analysis of a target molecule within a mixed specimen. A movable polarizer produces a segmented band of partially polarized polychromatic light from the band of partially polarized polychromatic light. A specimen cell adapted for receiving the mixed specimen transports the segmented band of partially polarized polychromatic light to the mixed specimen. A movable polarizing analyzer is optically coupled to the segmented band of partially polarized polychromatic light exiting the mixed specimen. The segmented band of partially polarized polychromatic light before entering the mixed specimen is compared with the segmented band of partially polarized polychromatic light after exiting the mixed specimen. The movable polarizer is synchronized with the movable polarizing analyzer.
Type:
Grant
Filed:
May 18, 2001
Date of Patent:
July 15, 2003
Assignee:
Xoetronics LLC
Inventors:
Frank Madarasz, Darell Engelhaupt, James Wyly, Joseph Milelli
Abstract: In an opto-electronic device utilizing a band of light for quantitative analysis of a specimen containing a target molecule, the opto-electronic device comprising a specimen cell adapted for receiving the specimen and for transporting the band of light, a device for comparing the band of light before entering the specimen with the band of light after exiting the specimen, wherein the target molecule. The device for comparing comprises: an optical sensor; and, a signal processor for determining a quantitative level of the target molecule within the specimen. The signal processor utilizes Bayes' Theorem for determining the quantitative level of the target molecule within the specimen.
Type:
Grant
Filed:
February 17, 2000
Date of Patent:
July 8, 2003
Assignee:
Xoetronics LLC
Inventors:
Frank L. Madarasz, Darell Engelhaupt, Ramarao Inguva, David P. Krivoshik, R. Joseph Milelli, James K. Wyly
Abstract: An optical quantitative detection device comprising: a nonlinear waveguide sensor having a top cladding layer with a top surface for interacting with a target molecule; a second waveguide; a second cladding layer optically coupling the nonlinear waveguide sensor to the second waveguide. Wherein optical excitation of the sensor and optical excitation of the second waveguide enables quantitative discrimination of a target molecule.