Abstract: A method is provided for reducing the occurrence of fever, headache, nausea and/or vomiting associated with administration of a therapeutic compound to a mammal in need thereof, comprising administering to the mammal a first conditioning dose of a non-target cell depleting compound which binds to a cell surface receptor on a target mammalian cell; and administering a second therapeutic dose of the compound, wherein the second dose is higher than the first dose.
Type:
Application
Filed:
October 30, 2007
Publication date:
February 28, 2008
Applicants:
Genentech, Inc., Xoma Ltd.
Inventors:
Marvin Garovoy, Susan Kramer, Russell Dedrick, Karen Starko
Abstract: A method is provided for reducing the occurrence of fever, headache, nausea and/or vomiting associated with administration of a therapeutic compound to a mammal in need thereof, comprising administering to the mammal a first conditioning dose of a non-target cell depleting compound which binds to a cell surface receptor on a target mammalian cell; and administering a second therapeutic dose of the compound, wherein the second dose is higher than the first dose.
Type:
Application
Filed:
September 5, 2003
Publication date:
March 11, 2004
Applicants:
Genentech, Inc., Xoma Ltd.
Inventors:
Marvin R. Garovoy, Susan M. Kramer, Russell L. Dedrick, Karen Starko
Abstract: A method is provided for reducing the occurrence of fever, headache, nausea and/or vomiting associated with administration of a therapeutic compound to a mammal in need therof, comprising administering to the mammal a first conditioning dose of a non-target cell depleting compound which binds to a cell surface receptor on a target mammalian cell; and administering a second therapeutic dose of the compound, wherein the second dose is higher than the first dose.
Type:
Grant
Filed:
February 11, 2002
Date of Patent:
November 25, 2003
Assignees:
Genentech, Inc., XOMA Ltd.
Inventors:
Marvin R. Garovoy, Susan M. Kramer, Russell L. Dedrick, Karen Starko
Abstract: The invention relates to cDNA genetic sequences, vehicles containing same as well as hosts tansformed therewith, for the production of chimeric immunoglobulin molecules, functional fragments thereof and immunoglobulin derivatives exhibiting novel functional properties comprising human constant region modules and non-human variable region modules, or for class switching antibody molecules and/or chains.
The invention also relates to DNA coding for pectate lyase signal peptide has been cloned on a plasmid to create a secretion vector which is capable of producing a chosen protein which is transported across the bacterial membrane. The secretion vector has been used to secrete extracellular thaumatin and extracellular chimeric antibody fragments. The proteins produced by this vector have biological activity. The thaumatin is properly folded and the antibody fragments are capable of binding antigens on target cancer cells.
Type:
Grant
Filed:
June 6, 1995
Date of Patent:
March 20, 2001
Assignee:
XOMA Ltd.
Inventors:
Randy R. Robinson, Alvin Y. Liu, Arnold H. Horwitz, Marc Better, Randolph Wall, Shau-Ping Lei, Gary L. Wilcox