Patents Assigned to XOMA
  • IL-1? binding antibodies and fragments thereof
    Patent number: 7531166
    Abstract: An IL-1? binding antibody or IL-1? binding fragment thereof comprising the amino acid sequence of SEQ ID NO: 2, and related nucleic acids, vectors, cells, and compositions, as well as method of using same to treat or prevent a disease, and a method of preparing an affinity matured IL-1? binding polypeptide. IL-1? binding antibodies or IL-1? binding fragments thereof are provided which have desirable affinity and potency.
    Type: Grant
    Filed: June 21, 2006
    Date of Patent: May 12, 2009
    Assignee: XOMA Technology, Ltd.
    Inventors: Linda Masat, Mary Haak-Frendscho, Gang Chen, Arnold Horwitz, Marina Roell
  • METHODS FOR DIAGNOSIS AND TREATMENT OF PROLIFERATIVE DISORDERS MEDIATED BY CD40 SIGNALING
    Publication number: 20090041773
    Abstract: Methods for identifying subjects having a cancer or pre-malignant condition that will benefit from anti-CD40 therapeutic agents that modulate CD40L-mediated CD40 signaling are provided. The methods comprise the use of biomarkers of cellular apoptosis, cell proliferation and survival, and CD40 signaling pathways to monitor ex vivo response to one or more anti-CD40 therapeutic agents of interest that modulate CD40 signaling on CD40-expressing neoplastic cells. The ex vivo prognostic assays can be used alone or in conjunction with other prognostic assays to identify candidate subjects who will benefit from treatment with anti-CD40 therapeutic agents. Methods of the invention also comprise the use of these biomarkers to monitor in vivo efficacy of treatment with an anti-CD40 therapeutic agent.
    Type: Application
    Filed: May 18, 2006
    Publication date: February 12, 2009
    Applicants: Novartis Vaccines and Diagnostics , Inc., XOMA Technology Ltd.
    Inventors: Sharon Lea Aukerman, Bahija Jallal, Mohammad Luqman
  • PRLR-Specific Antibody and Uses Thereof
    Publication number: 20080292620
    Abstract: PRLR-specific antibodies are provided, along with pharmaceutical compositions containing such antibody, kits containing a pharmaceutical composition, and methods of preventing and treating cancer.
    Type: Application
    Filed: August 17, 2007
    Publication date: November 27, 2008
    Applicants: NOVARTIS AG, XOMA TECHNOLOGY LTD.
    Inventors: Jason Damiano, Mohammad Luqman, Daniel Bedinger, Linda Masat, Amer Mirza, Genevieve Nonet
  • Methods for Diagnosis and Treatment of Diseases Having an Autoimmune and/or Inflammatory Component
    Publication number: 20080274118
    Abstract: Methods for identifying subjects having an inflammatory disease and/or autoimmune disease that will benefit from anti-CD40 therapeutic agents that modulate CD40L-mediated CD40 signaling are provided. The methods comprise the use of biomarkers of cellular apoptosis, cell proliferation and survival, and CD40 signaling pathways to monitor ex vivo response to one or more anti-CD40 therapeutic agents of interest that modulate CD40 signaling on CD40-expressing cells. The ex vivo prognostic assays can be used alone or in conjunction with other prognostic assays to identify candidate subjects who will benefit from treatment with anti-CD40 therapeutic agents. Methods of the invention also comprise the use of these biomarkers to monitor in vivo efficacy of treatment with an anti-CD40 therapeutic agent.
    Type: Application
    Filed: May 18, 2006
    Publication date: November 6, 2008
    Applicants: Novartis Vaccines and Diagnostics, Inc., XOMA Technology Ltd.
    Inventors: Sharon Lea Aukerman, Bahija Jallal, Mohammad Luqman
  • Nucleic acids encoding Human Engineered heavy and light chain variable region sequences to Ep-CAM
    Publication number: 20080241126
    Abstract: Human engineered anti-Ep-CAM antibodies and various uses therefore are disclosed. These human engineered anti-Ep-CAM antibodies have high affinity binding to Ep-CAM with low immunogenicity.
    Type: Application
    Filed: November 2, 2007
    Publication date: October 2, 2008
    Applicant: XOMA TECHNOLOGY LTD.
    Inventors: Marc D. Better, Arnold H. Horwitz
  • Uses Of Antibody To M-Csf
    Publication number: 20080233118
    Abstract: Methods of using M-CSF antibodies to treat macrophage-associated diseases including atherosclerosis and HIV are provided.
    Type: Application
    Filed: July 27, 2006
    Publication date: September 25, 2008
    Applicants: NOVARTIS AG, XOMA Technology Ltd.
    Inventor: William M. Kavanaugh
  • Eukaryotic signal sequences for polypeptide expression and polypeptide display libraries
    Publication number: 20080214411
    Abstract: The present invention generally relates to methods and compositions for expressing proteins or polypeptides in prokaryotic hosts using eukaryotic signal sequences.
    Type: Application
    Filed: January 25, 2008
    Publication date: September 4, 2008
    Applicant: XOMA TECHNOLOGY LTD.
    Inventors: Jeff Gray, Joe Buechler, Uday Kumar Veeramallu
  • Eukaryotic signal sequences for polypeptide expression and polypeptide display libraries
    Patent number: 7396661
    Abstract: The present invention generally relates to methods and compositions for expressing proteins or polypeptides in prokaryotic hosts using eukaryotic signal sequences.
    Type: Grant
    Filed: February 13, 2003
    Date of Patent: July 8, 2008
    Assignee: XOMA Technology Ltd.
    Inventors: Jeff Gray, Joe Buechler, Uday Kumar Veeramallu
  • Methods and Materials for Increasing Expression of Recombinant Polypeptides
    Publication number: 20080145895
    Abstract: The present invention provides novel methods and materials for increasing the expression of recombinant polypeptides. Methods and materials of the invention allow increased expression of transcription units that include recombinant DNA sequences which encode polypeptides of interest. The present invention provides expression vectors which contain multiple copies of a transcription unit encoding a polypeptide of interest separated by at least one selective marker gene and methods for sequentially transforming or transfecting host cells with expression vectors to increase transcription unit dosage and expression.
    Type: Application
    Filed: August 7, 2007
    Publication date: June 19, 2008
    Applicant: XOMA TECHNOLOGY LTD.
    Inventor: Arnold H. Horwitz
  • Methods and Materials for Expression of a Recombinant Protein
    Publication number: 20080145894
    Abstract: Recombinant expression vectors are provided comprising a 3?UTR of a light chain and an Epstein-Barr virus origin of replication. Also provided are host cells comprising such vectors and methods of producing recombinant protein with such vectors. Additional methods of producing a recombinant protein involve contacting cells with a first and second vector, each of which encode a different polypeptide chain, and wherein the second vector is present in an amount which is about 1.5 to 2.5 times as much as that of the first vector. Cells also can be transfected with a recombinant transient expression vector encoding a protein and are cultured in a medium in a membrane-enhanced culturing vessel to produce recombinant protein.
    Type: Application
    Filed: July 31, 2007
    Publication date: June 19, 2008
    Applicant: XOMA TECHNOLOGY LTD.
    Inventors: Masahisa Handa, Arnold Horwitz, Eddie Bautista, Robyn Cotter
  • Methods and Materials for Expression of a Recombinant Protein
    Publication number: 20080124762
    Abstract: Recombinant expression vectors are provided comprising a 3? UTR of a light chain and an Epstein-Barr virus origin of replication. Also provided are host cells comprising such vectors and methods of producing recombinant protein with such vectors. Additional methods of producing a recombinant protein involve contacting cells with a first and second vector, each of which encode a different polypeptide chain, and wherein the second vector is present in an amount which is about 1.5 to 2.5 times as much as that of the first vector. Cells also can be transfected with a recombinant transient expression vector encoding a protein and are cultured in a medium in a membrane-enhanced culturing vessel to produce recombinant protein.
    Type: Application
    Filed: July 31, 2007
    Publication date: May 29, 2008
    Applicant: XOMA TECHNOLOGY LTD.
    Inventors: Masahisa Handa, Arnold Horwitz, Eddie Bautista, Robyn Cotter
  • Modulation of Pericyte Proliferation
    Publication number: 20080119410
    Abstract: Methods and materials for modulating pericyte and epithelial cell proliferation relating to BPI protein products or inhibitors thereof are provided.
    Type: Application
    Filed: October 8, 2007
    Publication date: May 22, 2008
    Applicant: XOMA TECHNOLOGY LTD.
    Inventors: George L. King, Susan Abrahamson, Michael Pugsley
  • Treatment of LFA-1 Associated Disorders with Increasing Doses of LFA-1 Antagonist
    Publication number: 20080050364
    Abstract: A method is provided for reducing the occurrence of fever, headache, nausea and/or vomiting associated with administration of a therapeutic compound to a mammal in need thereof, comprising administering to the mammal a first conditioning dose of a non-target cell depleting compound which binds to a cell surface receptor on a target mammalian cell; and administering a second therapeutic dose of the compound, wherein the second dose is higher than the first dose.
    Type: Application
    Filed: October 30, 2007
    Publication date: February 28, 2008
    Applicants: Genentech, Inc., Xoma Ltd.
    Inventors: Marvin Garovoy, Susan Kramer, Russell Dedrick, Karen Starko
  • Methods and materials for increasing expression of recombinant polypeptides
    Publication number: 20070281334
    Abstract: The present invention provides novel methods and materials for increasing the expression of recombinant polypeptides. Methods and materials of the invention allow increased expression of transcription units that include recombinant DNA sequences which encode polypeptides of interest. The present invention provides expression vectors which contain multiple copies of a transcription unit encoding a polypeptide of interest separated by at least one selective marker gene and methods for sequentially transforming or transfecting host cells with expression vectors to increase transcription unit dosage and expression.
    Type: Application
    Filed: February 9, 2007
    Publication date: December 6, 2007
    Applicant: XOMA Technology Ltd.
    Inventor: Arnold Horwitz
  • Modulation of pericyte proliferation
    Patent number: 7291451
    Abstract: Methods and materials for modulating pericyte and epithelial cell proliferation relating to BPI protein products or inhibitors thereof are provided.
    Type: Grant
    Filed: November 19, 2004
    Date of Patent: November 6, 2007
    Assignee: XOMA Technology Ltd.
    Inventors: George L. King, Susan Abrahamson, Michael Pugsley
  • Methods for recombinant peptide production
    Patent number: 7247454
    Abstract: The present invention provides improved methods for the production of recombinant peptides from bacterial cells.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: July 24, 2007
    Assignee: XOMA Technology Ltd.
    Inventors: Marc D. Better, Patrick D. Gavit
  • Methods and materials for increasing expression of recombinant polypeptides
    Patent number: 7192737
    Abstract: The present invention provides novel methods and materials for increasing the expression of recombinant polypeptides. Methods and materials of the invention allow increased expression of transcription units that include recombinant DNA sequences which encode polypeptides of interest. The present invention provides expression vectors which contain multiple copies of a transcription unit encoding a polypeptide of interest separated by at least one selective marker gene and methods for sequentially transforming or transfecting host cells with expression vectors to increase transcription unit dosage and expression.
    Type: Grant
    Filed: March 31, 2003
    Date of Patent: March 20, 2007
    Assignee: XOMA Technology Ltd.
    Inventor: Arnold H. Horwitz
  • Eukaryotic signal sequences for prokaryotic expression
    Patent number: 7094579
    Abstract: The present invention generally relates to methods and compositions for expressing proteins or polypeptides in prokaryotic hosts using eukaryotic signal sequences.
    Type: Grant
    Filed: February 13, 2002
    Date of Patent: August 22, 2006
    Assignee: XOMA Technology Ltd.
    Inventors: Jeff Gray, Joe Buechler, Uday Kumar Veeramallu
  • Method of treating chronic cardiac disease
    Publication number: 20060171937
    Abstract: New therapeutic uses for BPI protein products that involve treatment of chronic cardiac disease.
    Type: Application
    Filed: April 5, 2006
    Publication date: August 3, 2006
    Applicants: XOMA Technology Ltd., THE UNIVERSITY OF TEXAS
    Inventors: Brett Giroir, Patrick Scannon
  • Method for quantifying LBP in body fluids
    Patent number: 7081334
    Abstract: The present invention provides a method for quantifying the presence of extracellular LBP in body fluids including blood in a subject comprising conducting an LBP immunoassay on plasma obtained from said subject.
    Type: Grant
    Filed: November 26, 2001
    Date of Patent: July 25, 2006
    Assignee: Xoma Corporation
    Inventors: Mark Leslie White, Stephen Fitzhugh Carroll, Jeremy Kam-kuen Ma