Abstract: A mouth-operated control device comprising an arched casing (10) configured for at least part of the casing (10) to be arranged between a maxillary dentition and a mandibular dentition of the user in an operating position, a first at least bidirectional input interface (21) housed in the concave region of the casing (10) and accessible to the tongue of the user; a second at least bidirectional input interface (22) in the part of the casing (10) intended for being arranged between the maxillary dentition and the mandibular dentition selected to be arranged facing the mandibular dentition of the user, allowing the operation thereof with the relative movement between the maxillary dentition and the mandibular dentition of the user; and a control electronics (30) connected to all the input interfaces (21, 22, 23) for the transmission of control signals to an external device.