Abstract: The present invention relates to the field of methods for providing pharmaceutical compositions comprising poorly water-soluble drugs. In particular the present invention relates to compositions comprising stable, amorphous hybrid nanoparticles, comprising at least one protein kinase inhibitor and at least one polymeric stabilizing and matrix-forming component, useful in pharmaceutical compositions and in therapy.

Abstract: A production arrangement for producing a batch of particles having predetermined sizes and/or morphology comprising at least a) two or more spray nozzles, each having a fluid transport conduit, a solution transport conduit, and a mixing arrangement for mixing a fluid and a solution with each other downstream of the fluid transport conduit, and a spray outlet, b) one or more particle collecting chambers, each comprising the spray outlet of at least one of the spray nozzles and a function for separating and collecting particles produced in the spray nozzle from the solution-fluid mixture, and c) a transport conduit external to the spray nozzles for transferring fluid to the fluid transport conduits of the spray nozzles, wherein the spray nozzles are identical and adapted to be run simultaneously with at least two of them being placed in a same particle collecting chamber and/or in different particle collecting chambers.

Abstract: A method for producing particles, from a substance, having predetermined size and/or morphology characteristics. The method consists of mixing within a spray nozzle a solution stream containing the substance in dissolved or dispersed form with a supercritical fluid stream. Spraying the mixture through a nozzle into a particle collecting chamber and there separating the particles. The characteristic feature is an additional step, providing a make-up agent (modifier) to the fluid stream, possibly combined with recycling of the fluid and/or performing the method essentially simultaneously in several spray nozzles. Additional features are also a production system comprising functions for performing the method above and the introduction of the make-up agent, recycling of the fluid and performing several runs essentially simultaneously in the same production system. Also a pharmaceutical formulation in which particles produced according to the method has been used for its manufacture.

Abstract: A method for producing particles of predetermined sized and/or morphology of a substance in a production arrangement comprising the steps of: i) mixing within a spray nozzle and under flow conditions a stream of a liquid solution in which the substance is dissolved with a stream of a fluid, and ii) passing the mixture in the form of a spray through a spray outlet of the nozzle into a particle collecting container, and iii) separating and collecting within the container the particles. The characteristic feature is that the solvent is a liquid and the fluid is an aqueous liquid in a subcritical state. Preferred nozzles have two coaxial internal transport conduits. One aspect is a production arrangement that can be used in the method. Its characteristic features are functions for a) recycling fluid used in the process, b) for including a make-up agent in the fluid stream, and/or increasing production by paralleling particle formation.

Abstract: Disclosed is a device for producing small particles of a certain substance, the device including first inlet for a solution or a suspension containing the substance and second inlet for an atomizing agent, a mixing area for the solution and the atomizing agent and outlet for the particles, and a first and second conduit provided from the first and second inlet means respectively to the mixing means.