Patents Assigned to Yale Univeristy
  • Publication number: 20120237997
    Abstract: A device for separating a sample of cells suspended in a bio-compatible ferrofluid is described. The device includes a microfluidic channel having a sample inlet, at least one outlet and a length between the same inlet and the at least one outlet, wherein a sample can be added to the sample inlet and flow along the microfluidic channel length to the at least one outlet. The device includes a plurality of electrodes and a power source for applying a current to the plurality of electrodes to create a magnetic field pattern along the microfluidic Channel length. The present invention also includes a method of using said device for separating at least one cell type.
    Type: Application
    Filed: December 7, 2010
    Publication date: September 20, 2012
    Applicant: Yale Univeristy
    Inventor: Hur Koser
  • Publication number: 20100035284
    Abstract: The invention relates, in part, to methods of using proteomic biomarkers to diagnose preeclampsia. In some aspects the invention, in part, relates to the detection of serpina-1 polypeptide and/or albumin polypeptide in samples from pregnant subjects. Samples from subjects may be compared to control samples to diagnose preeclampsia and/or to determine the onset, progression, or regression of preeclampsia in a subject. The invention also relates, in part, to screening methods to identify agents that can be used to treat preeclampsia and to determine the efficacy of a preeclampsia treatment. The invention, in part, also includes kits that are useful to diagnose and assess preeclampsia in a subject.
    Type: Application
    Filed: October 27, 2006
    Publication date: February 11, 2010
    Applicant: yale Univeristy
    Inventors: Catalin S. Buhimschi, Irina Buhimschi
  • Publication number: 20090318491
    Abstract: The present invention relates to compounds which are derivatives of cytisine or acetylcholine which exhibit activity as agonists, partial agonists or antagonists of nicotinic acetylcholine receptors and may be used in modulating these receptors and in treating mood disorders in patients in need of therapy.
    Type: Application
    Filed: January 26, 2007
    Publication date: December 24, 2009
    Applicants: Yale Univeristy, Reheinische Friedrich-Wilhelms- Univeristy Bonn
    Inventors: Marina Picciotto, Daniela Gundisch, Lenka Munoz, Matthias Andra, Yann Mineur