Abstract: The invention relates to a method of treating inflammatory conditions in a subject comprising administering to a subject a composition comprising a lymphoid thymosin-?4 polypeptide or a functional lymphoid thymosin-?4polypeptide variant. The invention also provides a method of promoting wound healing in a subject comprising administering to the subject a composition comprising a lymphoid thymosin-?4 polypeptide or a functional lymphoid thymosin-?4polypeptide variant. The invention also relates to methods of treating the above mentioned conditions in a subject comprising administering to the subject a nucleic acid encoding a lymphoid thymosin-?4 polypeptide or a functional lymphoid thymosin-?4 polypeptide variant. The invention also relates to pharmaceutical compositions comprising a lymphoid thymosin-?4 polypeptide or a functional lymphoid thymosin-?4polypeptide variant, or salt thereof, and a pharmaceutically acceptable carrier.