Patents Assigned to Yale University School of Medicine
  • INTRANNASAL ADMINISTRATION OF KETAMINE TO TREAT DEPRESSION
    Publication number: 20140256821
    Abstract: Methods and compositions for the treatment of treatment-resistant depression are described. More specifically, the invention demonstrates that intranasal administration of ketamine is effective to ameliorate the symptoms of depression in a patient who has not responded to an adequate trial of one antidepressant in the current episode and has recurrent or chronic depressive symptoms (>2 years).
    Type: Application
    Filed: March 5, 2014
    Publication date: September 11, 2014
    Applicants: Icahn School of Medicine at Mount Sinai, National Institute of Health, Yale University School of Medicine
    Inventors: Dennis S. Charney, Sanjay J. Mathew, Husseini K. Manji, Carlos A. Zarate, John H. Krystal
  • Intranasal Administration of Ketamine to Treat Depression
    Publication number: 20070287753
    Abstract: Methods and compositions for the treatment of treatment-resistant depression are described. More specifically, the invention demonstrates that intranasal administration of ketamine is effective to ameliorate the symptoms of depression in a patient who has not responded to an adequate trial of one antidepressant in the current episode and has recurrent or chronic depressive symptoms (>2 years).
    Type: Application
    Filed: March 20, 2007
    Publication date: December 13, 2007
    Applicants: MOUNT SINAI SCHOOL OF MEDICINE, NATIONAL INSTITUTE OF HEALTH, YALE UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Dennis Charney, Sanjay Mathew, Husseini Manji, Carlos Zarate, John Krystal
  • Toll/interleukin-1 receptor adapter protein (TIRAP)
    Patent number: 7285535
    Abstract: TIRAP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing TIRAP polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: September 16, 2005
    Date of Patent: October 23, 2007
    Assignee: Yale University School of Medicine
    Inventors: Ruslan Medzhitov, Tiffany Horng, Gregory Barton
  • Toll/interleukin-1 receptor adapter protein (TIRAP)
    Patent number: 6960343
    Abstract: TIRAP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing TIRAP polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: November 1, 2005
    Assignee: Yale University School of Medicine
    Inventors: Ruslan Medzhitov, Tiffany Horng, Gregory Barton
  • Polynucleotides encoding human sodium bicarbonate cotransporters
    Patent number: 6200776
    Abstract: The hNBC3 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hNBC3 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: July 15, 1998
    Date of Patent: March 13, 2001
    Assignees: Yale University School of Medicine, SmithKline Beecham Corporation P.L.C., SmithKline Beecham Laboratories Pharmaceutiques
    Inventors: Walter F Boron, Antoine Michel Alain Bril, Nassirah Khandoudi, Xavier Martin, Steven Charles Jupe, Christopher John Rawlings, Trudy Rachel Doe
  • Human kidney sodium bicarbonate transporter (HNBC1A) polynucleotides
    Patent number: 6096517
    Abstract: HNBC1A polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HNBC1A polypeptides and polynucleotides in the design of protocols for the treatment of ischemia heart disease, arrhythmia, congestive heart disease, stroke and renal failure, among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: August 19, 1998
    Date of Patent: August 1, 2000
    Assignees: SmithKline Beecham Laboratories, Pharmaceutiques and Yale University School of Medicine
    Inventors: Antoine Michel Alain Bril, Nassirah Khandoudi, Xavier Martin, Walter F Boron