Abstract: The present invention provides a highly sensitive immunoassay system for estrogens, which utilizes as a labeled compound a biotinylated estradiol derivative of the formula (1)
wherein one of R1 and R2 is hydrogen and the other is a group represented by
wherein R3s are the same or different and represent an arginine residue or a lysine residue, x is 0 or 1, y is an integer from 1 to 5, and z is an integer from 1 to 3.
Type:
Grant
Filed:
July 17, 2001
Date of Patent:
January 21, 2003
Assignees:
Otsuka Pharmaceutical Co., Ltd., Yanaihara Institute, Inc.
Abstract: The present invention provides an immunoassay for phthalic acid esters, which comprises measuring the phthalic acid esters contained in a sample using an antibody produced with a conjugate of a carrier protein and a phthalic acid ester derivative represented by the formula
wherein R1 and R2 may be the same or different and are hydrogen, alkyl, cycloalkyl or phenylalkyl, with the proviso that both of R1 and R2 are not hydrogen; m is an integer from 1 to 5; and Y is amino or carboxyl.
Type:
Grant
Filed:
October 30, 2001
Date of Patent:
June 4, 2002
Assignees:
Otsuka Pharmaceutical Co., Ltd., Yanaihara Institute Inc.