Patents Assigned to YAQRIT LIMITED
  • Treating hyperammonemia, reducing plasma ammonia with TLR4 antagonists
    Patent number: 10639346
    Abstract: The present invention derives from the finding that increased levels of Toll like receptor 4 (TLR4) is associated with liver failure and renal dysfunction and/or brain dysfunction and that by decreasing TLR4 levels in vivo, the kidney and brain consequences of liver disease that are precipitated by superimposed infection or inflammation may be reduced. Accordingly, the invention provides TLR4 antagonists for use in a method of treating an individual suffering from liver disease presenting with renal or brain dysfunction.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: May 5, 2020
    Assignee: Yaqrit Limited
    Inventors: Rajiv Jalan, Naina Shah
  • Treating renal and liver dysfunction with TLR4 antagonists
    Patent number: 9889176
    Abstract: The present invention derives from the finding that increased levels of Toll like receptor 4 (TLR4) is associated with liver failure and renal dysfunction and/or brain dysfunction and that by decreasing TLR4 levels in vivo, the kidney and brain consequences of liver disease that are precipitated by superimposed infection or inflammation may be reduced. Accordingly, the invention provides TLR4 antagonists for use in a method of treating an individual suffering from liver disease presenting with renal or brain dysfunction.
    Type: Grant
    Filed: August 17, 2011
    Date of Patent: February 13, 2018
    Assignee: YAQRIT LIMITED
    Inventors: Rajiv Jalan, Naina Shah