Abstract: Disclosed herein is an aqueous emulsion. The lipid phase of the emulsion includes a blend of a therapeutically effective concentration of a lipophile, a concentration of Vitamin E TPGS, and a concentration of linoleic acid. The presence of linoleic acid increases the solubilizing affect of Vitamin E TPGS on the lipophile and thus reduces the amount of Vitamin E TPGS that would otherwise be required in the aqueous emulsion.
Type:
Grant
Filed:
March 20, 2004
Date of Patent:
September 7, 2010
Assignee:
Yasoo Health, Inc.
Inventors:
Andreas M. Papas, Konstantinos A. Papas, Howard K. Hobbs, Warren Hopkins, William A. Clark
Abstract: Disclosed is an improved method for preparing the isoflavonoid compound (+/?)-equol, the method comprising reducing an organic diester of the isoflavone daidzein under hydrogen-transfer conditions using palladium hydroxide catalyst.
Abstract: A process of forming a d-tocotrienol from a (2S)-vinylchromane compound, through hydroboration of the (2S)-vinylchromane to provide an organoborane, followed by coupling the organoborane with a halogenated C-14 sidechain compound under conditions of palladium-catalyzed cross-coupling is taught. Methods for providing the (2S)-vinylchromane compound and the halogenated C-14 compound are disclosed.
Type:
Grant
Filed:
October 12, 2004
Date of Patent:
May 2, 2006
Assignee:
Yasoo Health, Inc.
Inventors:
Elias A. Couladouros, Andreas M. Papas, Vassilios I. Moutsos, Maria Lampropoulou
Abstract: Disclosed are novel tocopherol ester compounds having the formula
wherein X is a chain of 2 or 3 carbon atoms, e.g., ethylene and trimethylene, joining the 2 carbonyl groups to which they are bonded; and R1 is a group having the formula —Y—R4 wherein Y is a selenium, tellurium or sulfur atom and R4 is an alkyl, cycloalkyl or aryl radical. The tocopherol ester compounds of formula (I) exhibit antiproliferative and growth inhibitory effects on breast cancer cell lines.
Type:
Grant
Filed:
March 20, 2003
Date of Patent:
April 6, 2004
Assignee:
Yasoo Health Inc.
Inventors:
Anastasios Keramidas, Andreani Odysseos, Andreas Michael Papas