Abstract: The present invention provides diastereomeric peptides derived from the T Cell Receptor alpha Transmembrane Domain, and lipophilic conjugates thereof, which peptides and conjugates are effective in preventing or treating T cell mediated inflammatory diseases. The invention provides pharmaceutical compositions comprising these diastereomeric peptides and conjugates, and uses thereof for therapy of inflammatory diseases, autoimmunity and graft rejection.
Type:
Application
Filed:
September 21, 2006
Publication date:
November 5, 2009
Applicant:
Yeda Research and Developent Co., Ltd. at the Weizman Institute of Science
Inventors:
Yechiel Shai, Irun R. Cohen, Francisco Quintana, Doron Gerber