Patents Assigned to Yeda Research and Development Co.
  • Combination therapy for a stable and long term engraftment using specific protocols for T/B cell depletion
    Patent number: 11504399
    Abstract: A method of treating a subject in need of a non-syngeneic cell or tissue graft is disclosed. The method comprising: (a) transplanting into a subject a dose of T cell depleted immature hematopoietic cells, wherein the T cell depleted immature hematopoietic cells comprise less than 5×105 CD3+ T cells per kilogram body weight of the subject, and wherein the dose comprises at least about 5×CD34+ cells per kilogram body weight of the subject, and wherein the T cell depleted immature hematopoietic cells are obtained by separating the T cells from the immature hematopoietic cells by magnetic cell sorting, and (b) administering to the subject a therapeutically effective amount of cyclophosphamide, wherein the therapeutically effective amount comprises 25-200 mg per body weight, thereby treating the subject.
    Type: Grant
    Filed: August 13, 2019
    Date of Patent: November 22, 2022
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Yair Reisner, Esther Bachar-Lustig
  • DIAGNOSIS OF FRONTOTEMPORAL DEMENTIA
    Publication number: 20220364175
    Abstract: A method of diagnosing Frontotemporal dementia (FTD) in a subject in need thereof is provided. The method comprising detecting a level of at least one micro RNA (miR) selected from the group consisting of hsa-miR-361-5p, hsa-miR-629-5p, hsa-miR-628-3p, hsa-miR-379-5p, hsa-miR-1-3p, hsa-miR-26a-5p, hsa-miR-125a-5p, hsa-miR-125b-5p, hsa-miR-142-5p and hsa-miR-340-5p in a biological sample of the subject, wherein when said level of said at least one micro RNA (miR) is higher than that in a control sample, it is indicative of FTD.
    Type: Application
    Filed: June 22, 2022
    Publication date: November 17, 2022
    Applicants: Yeda Research and Development Co. Ltd., UCL Business Ltd
    Inventors: Eran HORNSTEIN, Iddo MAGEN, Nancy-Sarah YACOVZADA, Jonathan ROHRER, Pietro FRATTA
  • TREATING ACUTE LIVER DISEASE WITH TLR-MIK INIHIBITORS
    Publication number: 20220362329
    Abstract: Methods of treating acute liver disease acute liver diseases are provided. Accordingly, there is provided a method of treating acute liver disease in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an agent capable of binding a component of a TLR-MYC signaling pathway selected from the group consisting of MYC, MYD88, TRIF and p38 and inhibiting expression and/or activity of the component.
    Type: Application
    Filed: July 28, 2022
    Publication date: November 17, 2022
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Eran ELINAV, Ido AMIT, Aleksandra Anna KOLODZIEJCZYK
  • Combination therapy for a stable and long term engraftment
    Patent number: 11497776
    Abstract: A method of treating a subject in need of a non-syngeneic cell or tissue graft is disclosed. The method comprising: (a) transplanting into a subject a dose of T cell depleted immature hematopoietic cells, wherein the T cell depleted immature hematopoietic cells comprise less than 5×105 CD3+ T cells per kilogram body weight of the subject, and wherein the dose comprises at least about 5×106 CD34+ cells per kilogram body weight of the subject; and subsequently (b) administering to the subject a therapeutically effective amount of cyclophosphamide, wherein the therapeutically effective amount comprises 25-200 mg per kilogram body weight, thereby treating the subject.
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: November 15, 2022
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Yair Reisner, Esther Bachar-Lustig
  • Reducing systemic regulatory t cell levels or activity for treatment of disease and injury of the CNS
    Patent number: 11492405
    Abstract: The present specification discloses a pharmaceutical composition comprising an active agent that causes reduction of the level of systemic immunosuppression in an individual for use in treating a disease, disorder, condition or injury of the CNS. The pharmaceutical composition is administered by a dosage regimen comprising at least one course of therapy, each course of therapy comprising in sequence a treatment session followed by an interval session of non-treatment.
    Type: Grant
    Filed: December 27, 2019
    Date of Patent: November 8, 2022
    Assignee: Yeda Research and Development Co. Ltd
    Inventors: Michal Eisenbach-Schwartz, Kuti Baruch, Neta Rosenzweig
  • Device and method for controlling respiration during sleep
    Patent number: 11491301
    Abstract: A device for controlling respiration during sleep based on the user physiological characteristic. The device includes an odor disperser for dispersing an odor; at least one detector for detecting a physiological characteristic of a user; and a controller for controlling respiration of the user by instructing the odor dispenser to disperse an odor responsive to detections by the at least one detector.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: November 8, 2022
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Anat Arzi, Lee Sela, Anton Plotkin, Aharon Weissbrod, Noam Sobel
  • CRISP-seq, an integrated method for massively parallel single cell RNA-seq and CRISPR pooled screens
    Patent number: 11485971
    Abstract: An expression construct is disclosed which comprises: (i) a DNA sequence which encodes at least one guide RNA (gRNA) operatively linked to a transcriptional regulatory sequence so as to allow expression of the gRNA in a target cell; (ii) a barcode sequence for identification of the at least one gRNA operatively linked to a transcriptional regulatory sequence so as to allow expression of the barcode sequence in the target cell.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: November 1, 2022
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Ido Amit, Diego Jaitin, David Lara-Astiaso, Assaf Weiner, Ido Yofe
  • Diagnosis of autoimmune diseases
    Patent number: 11480568
    Abstract: Assays and methods for diagnosing and treating autoimmune diseases. Particularly, the invention provides methods for differential diagnosis of specific autoimmune diseases, including autoimmune rheumatic disorders.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: October 25, 2022
    Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Rachel Sorek, Keren Jakobi-Brook, Pennina Safer, Irun R. Cohen
  • System and method for ultrasound analysis
    Patent number: 11478226
    Abstract: An exemplary system, method and computer-accessible medium for detecting an anomaly(ies) in an anatomical structure(s) of a patient(s) can be provided, which can include, for example, receiving imaging information related to the anatomical structure(s) of the patient(s), classifying a feature(s) of the anatomical structure(s) based on the imaging information using a neural network (s), and detecting the anomaly(ies) based on data generated using the classification procedure. The imaging information can include at least three images of the anatomical structure(s).
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: October 25, 2022
    Assignees: New York University, Yeda Research And Development Co., Ltd.
    Inventors: Itay Kezurer, Achiau Ludomirsky, Yaron Lipman
  • ELECTROMECHANICAL RESONATORS BASED ON METAL-CHALCOGENIDE NANOTUBES
    Publication number: 20220337222
    Abstract: This invention provides electromechanical resonators based on metal chalcogenide nanotubes. The invention further provides methods of fabrication of electromechanical resonators and methods of use of such electromechanical resonators.
    Type: Application
    Filed: June 30, 2022
    Publication date: October 20, 2022
    Applicants: YEDA RESEARCH AND DEVELOPMENT CO. LTD., B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., at Ben-Gurion University
    Inventors: Reshef TENNE, Ernesto JOSELEVICH, Yiftach DIVON, Roi LEVI, Assaf YAAKOBOVITZ, Dan YUDILEVICH
  • Method for platinum group metals recovery from spent catalysts
    Patent number: 11473168
    Abstract: A method for recovery of platinum group metals from a spent catalyst is described. The method includes crushing the spent catalyst to obtain a catalyst particulate material including particles having a predetermined grain size. The method includes subjecting the catalyst particulate material in the reaction zone at a predetermined temperature for a predetermined time period in contact with solid chlorine-containing material and solid silicon-containing material to obtain volatile platinum group metal-containing chloride product, and cooling to convert the product into solid phase platinum group metal-containing materials.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: October 18, 2022
    Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Igor Lubomirsky, Valery Kaplan, Ilya Bronshtein
  • Combination therapy for the treatment of cancer
    Patent number: 11471504
    Abstract: An article of manufacture is disclosed which comprises: (i) a peptide agent which is capable of preventing extracellular signal-regulated kinase1/2 (ERK) translocation into the nucleus; and (ii) a MEK inhibitor. Uses thereof are also disclosed.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: October 18, 2022
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Yardena Samuels, Rand Arafeh, Karen Flores, Rony Seger, Ehud Wainstein
  • Sphingosine analogs and use thereof against bacterial lung infections
    Patent number: 11471430
    Abstract: Provided herein is a group of sphingosine analogs, useful in the treatment of bacterial infections in mucosal surfaces such as lungs, caused by pathogenic bacteria which are typical to disorders and diseases such as CF and COPD.
    Type: Grant
    Filed: July 17, 2019
    Date of Patent: October 18, 2022
    Assignees: Yeda Research and Development Co. Ltd., University of Duisburg-Essen
    Inventors: Anthony H. Futerman, Tammar Joseph, Walter A. Shaw, Stephen W. Burgess, Shengrong Li
  • METHOD AND SYSTEM FOR PREDICTING GESTATIONAL DIABETES
    Publication number: 20220328185
    Abstract: A method of predicting likelihood for gestational diabetes, comprises: obtaining a plurality of parameters characterizing a female subject, accessing a computer readable medium storing a machine learning procedure trained for predicting likelihoods for gestational diabetes, feeding the procedure with the plurality of parameters, and receiving from the procedure an output indicative of a likelihood that the subject has, or expected to develop, gestational diabetes, wherein the output indicative is related non-linearly to the parameters.
    Type: Application
    Filed: May 24, 2020
    Publication date: October 13, 2022
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Eran SEGAL, Smadar SHILO, Nitzan ARTZI
  • MICROFLUIDIC DEVICE FOR ANALYZING GENE EXPRESSION
    Publication number: 20220314221
    Abstract: A microfluidic device is disclosed which comprises: (i) at least one reaction unit having a test chamber connected to at least one microchannel, wherein a surface of at least a portion of said reaction unit is attached to an isolated nucleic acid; and (ii) a flow-through channel having at least one inlet port and at least one outlet port, said flow-through channel and said microchannel being of dimensions to allow reactant diffusion to and from said reaction unit, wherein the diffusion time of said reactant along the microchannel is shorter than the flow time along the microchannel.
    Type: Application
    Filed: June 14, 2022
    Publication date: October 6, 2022
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Roy BAR-ZIV, Eyal KARZBRUN, Alexandra TAYAR
  • TREATING ALZHEIMER'S DISEASE
    Publication number: 20220306710
    Abstract: A method of treating Alzheimer's Disease (AD) is disclosed. The method comprises administering to the subject a therapeutically effective amount of an agent which prevents the binding of amyloid precursor protein (APP) to Tau protein.
    Type: Application
    Filed: May 19, 2022
    Publication date: September 29, 2022
    Applicants: Yeda Research and Development Co. Ltd., Ramot at Tel-Aviv University Ltd.
    Inventors: Ruth ARNON, Ruth MARON, Gad ARMONY, Michael Menachem TSOORY, Meir WILCHEK, Dan FRENKEL
  • METHOD FOR STABILIZING INTRACELLULAR RNA
    Publication number: 20220307008
    Abstract: A method of permeabilizing a cell is disclosed. Kits for permeabilizing cells and analysing RNA contents are also disclosed.
    Type: Application
    Filed: June 16, 2020
    Publication date: September 29, 2022
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Ido AMIT, Ido YOFE, Diego JAITIN, Yonatan KATZENELENBOGEN, Mami LENNIKOV, Assaf WEINER, Hadas KEREN-SHAUL
  • Attenuation of encrustation of medical devices using coatings of inorganic fullerene-like nanoparticles
    Patent number: 11446413
    Abstract: A new approach is presented to reduce encrustation of catheters by the application of nanoparticles. It is demonstrated that the negatively surface charged nanoparticles produce coating films comprised of long-range domains in which the nanoparticles are self-assembled into a mosaic-like order, showing a relatively small tendency to agglomerate.
    Type: Grant
    Filed: January 6, 2015
    Date of Patent: September 20, 2022
    Assignees: YEDA RESEARCH AND DEVELOPMENT CO. LTD., MOR RESEARCH APPLICATIONS LTD.
    Inventors: Reshef Tenne, David Zbaida, Racheli Ron, Ilan Kafka, Ilan Leibovitch
  • Device for electric field induced local magnetization
    Patent number: 11437501
    Abstract: In a technique for inducing local electric field controlled magnetization, despite the absence of magnetic components, there is provided a novel heterostructure, a semiconductor device thereof, or an array of semiconductor devices. The heterostructure includes a semiconductor substrate carrying a plurality of layers forming at least one heterojunction and hosting a two-dimensional electron gas layer when one of the layer of the plurality of layers is bounded to an interacting layer being a chiral or a biological macromolecule assembly.
    Type: Grant
    Filed: April 7, 2019
    Date of Patent: September 6, 2022
    Assignees: Yeda Research and Development Co. Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yossef Paltiel, Ron Naaman, Karen Michaeli, Eilam Smolinsky
  • USE OF VETO CELLS FOR THE TREATMENT OF SICKLE CELL DISEASE
    Publication number: 20220265726
    Abstract: A method of treating or preventing a sickle cell disease in a subject in need thereof is disclosed. The method comprising: (a) transplanting immature hematopoietic cells into the subject; and (b) administering to the subject a therapeutically effective amount of an isolated population of non-GVHD inducing anti-third party cells comprising cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance inducing cells and capable of homing to the lymph nodes following transplantation.
    Type: Application
    Filed: May 5, 2022
    Publication date: August 25, 2022
    Applicants: Yeda Research and Development Co. Ltd., Board of Regents, The University of Texas System
    Inventors: Yair REISNER, Aloukick Kumar SINGH