Patents Assigned to Yeda Research and Development Company Ltd.
  • Publication number: 20200338001
    Abstract: The invention provides a method for lubricating one or more surfaces, comprising applying gel-phase liposomes onto said one or more surfaces, wherein the temperature of said surface(s) at the time of lubrication is below the phase transition temperature Tm of said liposomes. The method can be used for lubricating non-biological surfaces, and also for lubricating the surfaces of a biological tissue in a mammalian subject, e.g., for treating joint dysfunction.
    Type: Application
    Filed: March 5, 2020
    Publication date: October 29, 2020
    Applicants: YEDA RESEARCH AND DEVELOPMENT CO., LTD., YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM,
    Inventors: Jacob Klein, Ronit Goldberg, Yechezkel Barenholtz, Avi Schroeder
  • Publication number: 20190367940
    Abstract: Disclosed herein are genetically modified plants having altered biological activity of 3-?-hydroxysteroid dehydrogenase/isomerase (GAME25), or 2-oxoglutarate-dependent dioxygenase (GAME31), or a combination thereof, wherein the genetically modified plants have an altered content of at least one cholesterol derived compound selected from the group including a steroidal alkaloid or a glycosylated derivative thereof and an unsaturated or saturated steroidal saponin or a glycoside derivative thereof. Further disclosed herein are genetically modified plants having altered expression of a gene encoding a 3-?-hydroxysteroid dehydrogenase/isomerase (GAME25), or a 2-oxoglutarate-dependent dioxygenase (GAME31), or a combination thereof, wherein the genetically modified plant has an altered content of at least one cholesterol derived compound selected from the group including a steroidal alkaloid or a glycosylated derivative thereof and an unsaturated or saturated steroidal saponin or a glycoside derivative thereof.
    Type: Application
    Filed: February 8, 2018
    Publication date: December 5, 2019
    Applicants: YEDA RESEARCH AND DEVELOPMENT CO. LTD., Yissum Research Development Company, of The Hebrew University of Jerusalem Ltd.
    Inventors: Asaph AHARONI, Prashant SONAWANE, Pablo D. CARDENAS, BURDMAN Saul
  • Patent number: 9957293
    Abstract: Conjugates of porphyrin, chlorophyll and bacteriochlorophyll photosensitizers with RGD-containing peptides or RGD peptidomimetics are provided that are useful for photodynamic therapy (PDT), particularly vascular-targeted PDT (VTP), of tumors and nonneoplastic vascular diseases such as age-related macular degeneration, and for diagnosis of tumors by different techniques.
    Type: Grant
    Filed: April 16, 2012
    Date of Patent: May 1, 2018
    Assignee: YEDA RESEARCH AND DEVELOPMENT COMPANY LTD.
    Inventors: Avigdor Scherz, Yoram Salomon, Efrat Rubinstein, Alexander Brandis, Doron Eren, Karin Neimann
  • Patent number: 9164034
    Abstract: A device is presented comprising a multi-layer structure with a plurality of metal islands on the surface of a solid transparent substrate. The islands are coated by an ultrathin sol-gel derived silica film via self-assembled monolayer.
    Type: Grant
    Filed: June 5, 2009
    Date of Patent: October 20, 2015
    Assignee: YEDA RESEARCH AND DEVELOPMENT COMPANY LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE
    Inventors: Israel Rubinstein, Alexander Vaskevich, Irit Ruach-Nir, Tatyana Bendikov
  • Patent number: 9006206
    Abstract: Described herein are compositions and methods for modulation of p53-dependent cell death and cell proliferation. The compositions are microRNAs and associated nucleic acids.
    Type: Grant
    Filed: May 19, 2014
    Date of Patent: April 14, 2015
    Assignees: Rosetta Genomics Ltd., Yeda Research and Development Company Ltd.
    Inventors: Moshe Oren, Nina Raver-Shapira, Efi Marciano, Yael Spector
  • Publication number: 20140256789
    Abstract: Described herein are compositions and methods for modulation of p53-dependent cell death and cell proliferation. The compositions are microRNAs and associated nucleic acids.
    Type: Application
    Filed: May 19, 2014
    Publication date: September 11, 2014
    Applicants: YEDA RESEARCH AND DEVELOPMENT COMPANY LTD., ROSETTA GENOMICS, LTD.
    Inventors: Moshe Oren, Nina Raver-Shapira, Efi Marciano, Yael Spector
  • Patent number: 8802675
    Abstract: Multifunctional compounds are provided, comprising two or more functional moieties selected from: (i) a moiety that imparts an iron chelator function; (ii) a moiety that imparts a neuroprotective function; (iii) a moiety that imparts combined antiapoptotic, neuroprotective and/or neurorestorative functions; (iv) a moiety that imparts brain MAO inhibition, preferably with little or no MAO inhibition in liver and small intestine; (v) a moiety that imparts cholinesterase inhibitory function; and (vi) a moiety that imparts an N-methyl-D-aspartic acid receptor (NMDAR) inhibition, and pharmaceutically acceptable salts and optical isomers thereof. The multifunctional compounds are useful in the treatment or prevention of diseases, disorders or conditions that can be prevented and/or treated by iron chelation therapy, and/or neuroprotection and/or neurorestoration, and/or apoptosis inhibition and/or MAO inhibition and/or cholinesterase inhibition and/or NMADR inhibition.
    Type: Grant
    Filed: January 31, 2010
    Date of Patent: August 12, 2014
    Assignees: Technion Research and Development Foundation Ltd, Yeda Research and Development Company Ltd.
    Inventors: Moussa B. H. Youdim, Mati Fridkin, Hailin Zheng
  • Patent number: 8797532
    Abstract: Measuring polarization profile along an input optical beam cross-section using an optical system includes a polarization beam splitting assembly for splitting the input beam into a predetermined number of beam components with a predetermined polarization relation between them, and including a polarization beam splitter in an optical path of the input beam splitting it into beam components having a polarization relationship and a birefringent element in an optical path of the beam components for splitting each of them into a pair of beams having ordinary and extraordinary polarizations, thereby producing the predetermined number of output beam components. The pixel matrix is located in substantially non-intersecting optical paths of the output beam components and generates a number of output data pieces indicative of intensity distribution within the output beam components and data contained therein being indicative of the polarization profile along the input beam cross-section.
    Type: Grant
    Filed: March 24, 2011
    Date of Patent: August 5, 2014
    Assignee: Yeda Research and Development Company Ltd.
    Inventors: Nir Davidson, Asher Friesem, Moti Fridman
  • Publication number: 20140196180
    Abstract: A device is presented having reversibly changeable and optically readable optical properties. The device comprises a substrate having an electrically conductive surface and carrying a redox-active layer structure. The redox-active layer structure may be a monolayer or a multi-layer structure and is configured to have at least one predetermined electronic property including at least one of electrodensity and oxidation state. The electronic property of the layer structure defines an optical property of the structure thereby determining an optical response of the structure to certain incident light. This at least one electronic property is changeable by subjecting the redox-active layer structure to an electric field or to a redox-active material. The device thus enables effecting a change in said electronic property that results in a detectable change in the optical response of the layer structure.
    Type: Application
    Filed: January 16, 2014
    Publication date: July 10, 2014
    Applicant: YEDA RESEARCH & DEVELOPMENT COMPANY LTD.
    Inventors: Milko E. VAN DER BOOM, Atindra D. Shukla, David Rosenblatt, Tarkeshwar Gupta
  • Patent number: 8764953
    Abstract: The present invention relates to a system comprising a heat source to provide heat at the desired temperature and energy field (e.g. a solar concentrator); an electron source configured and operable to emit electrons; an electric field generator generating an electric field adapted to supply energy sufficient to dissociate gas molecules; and a reaction gas chamber configured and operable to cause interaction between the electrons with the molecules, such that the electrons dissociate the molecules to product compound and ions via dissociative electrons attachment (DEA) within the chamber.
    Type: Grant
    Filed: August 23, 2012
    Date of Patent: July 1, 2014
    Assignee: Yeda Research and Development Company Ltd.
    Inventors: Jacob Karni, Gidon Ferdiman, Yury Alioshin
  • Patent number: 8765702
    Abstract: Described herein are compositions and methods for modulation of p53-dependent cell death and cell proliferation. The compositions are microRNAs and associated nucleic acids.
    Type: Grant
    Filed: February 26, 2008
    Date of Patent: July 1, 2014
    Assignees: Rosetta Genomics Ltd., Yeda Research and Development Company Ltd.
    Inventors: Moshe Oren, Nina Raver-Shapira, Efi Marciano, Yael Spector
  • Patent number: 8723514
    Abstract: The present invention discloses a novel magnetic sensor device performing direct magnetic field imaging, comprising a probe having a conical tip portion which is configured as a sensor having two superconductors separated by a thin non-superconducting layer (such as a Josephson junction based sensor), where the non-superconducting layer is located at the apex portion of said conical tip, thereby defining electron tunneling region(s) at said apex portion. The technique of the present invention enables the sensor device to be very small and to be brought very close to the sample surface.
    Type: Grant
    Filed: June 26, 2008
    Date of Patent: May 13, 2014
    Assignee: Yeda Research and Development Company Ltd.
    Inventors: Amit Finkler, Jens Martin, Yuri Myasoedov, Yehonathan Segev, Amir Yacoby, Eli Zeldov
  • Patent number: 8722879
    Abstract: A device is presented having reversibly changeable and optically readable optical properties. The device comprises a substrate having an electrically conductive surface and carrying a redox-active layer structure. The redox-active layer structure may be a monolayer or a multi-layer structure and is configured to have at least one predetermined electronic property including at least one of electrodensity and oxidation state. The electronic property of the layer structure defines an optical property of the structure thereby determining an optical response of the structure to certain incident light. This at least one electronic property is changeable by subjecting the redox-active layer structure to an electric field or to a redox-active material. The device thus enables effecting a change in said electronic property that results in a detectable change in the optical response of the layer structure.
    Type: Grant
    Filed: March 5, 2007
    Date of Patent: May 13, 2014
    Assignee: Yeda Research & Development Company Ltd. at the Weizmann Institute of Science
    Inventors: Milko E. Van Der Boom, Atindra D. Shukla, David Rosenblatt, Tarkeshwar Gupta
  • Patent number: 8529988
    Abstract: A method is presented for use in fabrication of metal islands on an oxide substrate. The method comprises: depositing a selected metal on the oxide substrate by evaporation of said selected metal; and annealing a film of the selected metal on said substrate at temperatures including an annealing temperature being less than 50° C. lower than a glass transition temperature, thereby forming the metal islands partially embedded in said substrate.
    Type: Grant
    Filed: April 7, 2009
    Date of Patent: September 10, 2013
    Assignee: Yeda Research and Development Company Ltd.
    Inventors: Israel Rubinstein, Alexander Vaskevich, Tatyana Karakouz
  • Patent number: 8518364
    Abstract: A nanostructure, being either an Inorganic Fullerene-like (IF) nanostructure or an Inorganic Nanotube (INT), having the formula A1?x-Bx-chalcogenide are described. A being a metal or transition metal or an alloy of metals and/or transition metals, B being a metal or transition metal B different from that of A and x being ?0.3. A process for their manufacture and their use for modifying the electronic character of A-chalcogenide are described.
    Type: Grant
    Filed: November 7, 2012
    Date of Patent: August 27, 2013
    Assignee: Yeda Research and Development Company Ltd.
    Inventors: Reshef Tenne, Francis Leonard Deepak, Hagai Cohen, Sidney R. Cohen, Rita Rosentsveig, Lena Yadgarov
  • Patent number: 8507853
    Abstract: The present invention relates to a novel system and method for the determination of depth profiling with improved accuracy and reliability. The method comprises obtaining spectroscopic data from the sample while under at least two different electrical conditions of the sample, the spectroscopic data comprising a signal of charged particles emitted from the sample, and being indicative of a change in amplitude, spectral position and spectral shape of the signal from the sample while under different electrical conditions of the sample, the change being indicative of the compositional profile and spatial distribution for at least one chemical element in the sample along a direction through the sample.
    Type: Grant
    Filed: October 22, 2009
    Date of Patent: August 13, 2013
    Assignee: Yeda Research and Development Company Ltd.
    Inventor: Hagai Cohen
  • Publication number: 20130109601
    Abstract: A nanostructure, being either an Inorganic Fullerene-like (IF) nanostructure or an Inorganic Nanotube (INT), having the formula A1?x-Bx-chalcogenide are described. A being a metal or transition metal or an alloy of metals and/or transition metals, B being a metal or transition metal B different from that of A and x being ?0.3. A process for their manufacture and their use for modifying the electronic character of A-chalcogenide are described.
    Type: Application
    Filed: November 7, 2012
    Publication date: May 2, 2013
    Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY LTD.
    Inventor: Yeda research and development company ltd.
  • Patent number: 8419984
    Abstract: A film is presented having super-pyroelectric properties. The film comprises nano-sized grains being in a ferroelectric phase and having at least three different crystallographic variants defining at least two polycrystalline macro-domains. The film is shaped to define at least one film region with the macro-domains of a predetermined shape and different orientations of crystallographic axes with respect to the film's surface, thereby enabling to apply a temperature change to the film to induce movement of the polycrystalline macro-domains boundaries enabling super-pyroelectric properties.
    Type: Grant
    Filed: June 17, 2007
    Date of Patent: April 16, 2013
    Assignees: Yeda Research and Development Company Ltd., University of Maryland
    Inventors: Igor Lubomirsky, Vera Lyahovitsky, Alexander L. Roytburd
  • Publication number: 20130087182
    Abstract: A solar energy conversion system is presented. The system comprises at least one waveguide arrangement having at least one light input respectively. The waveguide arrangement comprises a core unit for passing input solar radiation therethrough and a cladding material arrangement interfacing with the core therealong. The cladding material arrangement is configured as an array of spaced-apart solar cells arranged along the core unit and having different optical absorption ranges, such that an interface between the waveguide core and the cladding arrangement spectrally splits the photons of the input solar radiation by causing the photons of different wavelengths, while passing through the core unit, to be successively absorbed and thereby converted into electricity by the successive solar cells of said array.
    Type: Application
    Filed: November 29, 2012
    Publication date: April 11, 2013
    Applicants: BAR ILAN UNIVERSITY, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.
    Inventors: Bar Ilan University, Yeda Research and Development Company, Ltd., The Regents of the University of California
  • Publication number: 20130043138
    Abstract: The present invention relates to a system comprising a heat source to provide heat at the desired temperature and energy field (e.g. a solar concentrator); an electron source configured and operable to emit electrons; an electric field generator generating an electric field adapted to supply energy sufficient to dissociate gas molecules; and a reaction gas chamber configured and operable to cause interaction between the electrons with the molecules, such that the electrons dissociate the molecules to product compound and ions via dissociative electrons attachment (DEA) within the chamber.
    Type: Application
    Filed: August 23, 2012
    Publication date: February 21, 2013
    Applicant: Yeda Research and Development Company Ltd.
    Inventors: Jacob KARNI, Gidon Ferdiman, Yury Alioshin