Patents Assigned to Yeda Research Development Co., Ltd.
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Patent number: 11977955Abstract: A quantum computing system comprises a plurality of photonic cavities, a plurality of coupling locations for quantum emitter positioning, a photon generator configured to supply photons to the plurality of photonic cavities, and a plurality of photon output channels downstream of the plurality of cavities to output a graph state. Each coupling location is associated with a differing one of the plurality of photonic cavities. Quantum emitters associated with each coupling location are configured to mediate interactions between consecutive incoming photonic qubits to generate the graph state, and the photonic cavities are configured to couple photonic qubits to the quantum emitters.Type: GrantFiled: April 13, 2023Date of Patent: May 7, 2024Assignees: Yeda Research and Development Co. Ltd., Quantum Source Labs Ltd.Inventors: Gil Semo, Ziv Aqua, Oded Melamed, Dan Charash, Serge Rosenblum, Barak Dayan
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Publication number: 20240139326Abstract: This invention is directed to substituted a methacrylamide compounds as targeted covalent protein binders and uses thereof.Type: ApplicationFiled: December 23, 2021Publication date: May 2, 2024Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.Inventors: Nir LONDON, Efrat RESNICK, Rambabu REDDI, Adi ROGEL
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Patent number: 11972324Abstract: Generating photonic graph states includes positioning a plurality of quantum emitters at a plurality of coupling sites associated with a plurality of cavities and initializing a state of a quantum emitter qubit associated with each of the plurality of quantum emitters. Photonic qubits are transmitted toward the plurality of the quantum emitters a first instance transmission for generating an entangling gate between the photonic qubits and the quantum emitter qubit in order to entangle the quantum emitter qubit and the photonic qubits. Following the first instance transmission, photonic qubits are transmitted toward the plurality of quantum emitters in a one second instance transmission for generating a SWAP gate between the photonic qubits and the quantum emitter qubits to map the quantum emitter qubits to photonic qubits.Type: GrantFiled: April 13, 2023Date of Patent: April 30, 2024Assignees: Yeda Research and Development Co. Ltd., Quantum Source Labs Ltd.Inventors: Gil Semo, Ziv Aqua, Oded Melamed, Dan Charash, Serge Rosenblum, Barak Dayan
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Publication number: 20240133870Abstract: Combined treatment for cancer is provided. Accordingly, there is provided a method of selecting or determining therapeutic efficacy of a combination of agents for the treatment of cancer in a subject in need thereof, the method comprising: (i) culturing a cancerous tissue of the subject in an ex-vivo organ culture (EVOC) in the presence of a combination of an anti-cancer agent and an additional agent, said additional agent is inhibiting expression and/or activity of a target conferring innate resistance to said anti-cancer agent or increasing expression and/or activity of a target conferring innate sensitivity to said anti-cancer agent; and (ii) determining an anti-cancer effect of the combination on the tissue, wherein responsiveness of the tissue to the combination indicates the combination is efficacious for the treatment of the cancer in the subject.Type: ApplicationFiled: December 6, 2023Publication date: April 25, 2024Applicant: Yeda Research and Development Co. Ltd.Inventors: Ravid STRAUSSMAN, Oded SANDLER
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Patent number: 11965885Abstract: Methods and kits for diagnosing or monitoring systemic lupus erythematosus (SLE) in a subject are provided. Particularly, the present invention relates to a specific antibody reactivity profile useful in diagnosing or monitoring SLE in a subject.Type: GrantFiled: May 27, 2021Date of Patent: April 23, 2024Assignee: Yeda Research and Development Co. Ltd.Inventors: Rachel Sorek, Keren Jakobi, Pennina Safer, Anat Reiner-Benaim, Irun R. Cohen
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Patent number: 11957102Abstract: The present invention relates to key genes in the biosynthesis of steroidal alkaloids and saponins, including regulatory genes and enzyme-encoding genes, and to use thereof for altering the content of steroidal (glyco)alkaloids or phytosterols in plants. The present invention provides genetically modified plants or gene edited plants with altered content of steroidal (glyco)alkaloids, particularly to Solanaceous crop plants with reduced content of antinutritional steroidal glycoalkaloids and to the increase in phytosterols, including cholesterol or cholestanol in these plants. The present invention also provides methods of altering gene expression.Type: GrantFiled: July 7, 2022Date of Patent: April 16, 2024Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.Inventors: Asaph Aharoni, Prashant Sonawane, Maxim Itkin
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Patent number: 11959097Abstract: Methods of generating a synthetic embryo are provided. Accordingly, there is provided a method of generating a synthetic embryo comprising inducing expression of a factor that induces differentiation to trophectoderm cells in a subpopulation of naïve pluripotent stem cells (PSCs) to obtain a trophectoderm primed cells; inducing expression of a factor that induces differentiation to extra embryonic primitive endodermal cells in a second subpopulation of naïve PSCs to obtain extra embryonic primitive endodermal primed cells; and mixing said trophectoderm primed cells and said extra embryonic primitive endodermal primed cells with naïve PSCs under conditions that allow formation of aggregated cells. Also provided are articles of manufactures, mixtures and aggregates of cells and methods of using same.Type: GrantFiled: July 27, 2023Date of Patent: April 16, 2024Assignee: Yeda Research and Development Co. Ltd.Inventors: Yaqub Hanna, Sergey Viukov, Emilie Wildschutz, Noa Novershtern, Carine Joubran, Segev Naveh Tassa, Alejandro Castrejon Aguilera, Bernardo Oldak, Shadi Tarazi, Francesco Roncato
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Publication number: 20240117386Abstract: A recombinant bacteria which is genetically modified to express formate dehydrogenase (FDH), phosphoribulokinase (prk) and Ribulose-Bisphosphate Carboxylase/oxygenase (RuBisCo) is disclosed. The bacteria may be modified to be autotrophic.Type: ApplicationFiled: October 22, 2020Publication date: April 11, 2024Applicant: Yeda Research and Development Co. Ltd.Inventors: Ron MILO, Shmuel GLEIZER, Niv ANTONOVSKY, Elad NOOR, Arren BAR-EVEN, Yehudit ZOHAR, Roee BEN NISSAN, Elad HERZ, Yinon Moise BAR-ON
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Patent number: 11944644Abstract: The present invention provides T-cells expressing at least two different chimeric antigen receptors, wherein one of the CARs binds specifically to CD138 and another CAR binds specifically to CD38. In particular, the present invention provides T-cells expressing two different CARs, when one CAR comprises anti-CD138 sc Fv and the second CAR anti-CD138 sc Fv. Further, the invention provides a pharmaceutical composition comprising these dual CAR T-cells and their use in treatment of cancer, in particular multiple myeloma, and methods for preparation of these cells.Type: GrantFiled: December 4, 2018Date of Patent: April 2, 2024Assignees: THE MEDICAL RESEARCH INFRASTRUCTURE AND HEALTH SERVICES FUND OF THE TEL AVIV MEDICAL CENTER, YEDA RESEARCH AND DEVELOPMENT CO. LTDInventors: Zelig Eshhar, Tova Waks, Anat Globerson Levin, Moran Rawet Slobodkin
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Publication number: 20240094224Abstract: Proxies for physiological states of tissue are provided. Accordingly, there are provided methods of determining host AMP landscape, establishing a profile indicative of tissue status, and identifying proxies for tissue status in AMP profiles of samples of secretions, exudates and/or excretions of the tissue. Also provided are methods for determination of disease severity and chronology.Type: ApplicationFiled: November 29, 2023Publication date: March 21, 2024Applicant: Yeda Research and Development Co. Ltd.Inventors: Eran ELINAV, Alon SAVIDOR
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Patent number: 11932887Abstract: The invention provides recombinant polynucleotides comprising a nucleic acid encoding a CYP76AD6 or related gene and their use for producing L-DOPA from tyrosine. The invention also provides recombinant polynucleotides comprising a nucleic acid encoding a CYP76AD1 and/or CYP76AD6, a nucleic acid encoding a DOPA 4,5-dioxygenase (DOD) enzyme, such as Beta vulgaris DODA1, and, in some cases, a nucleic acid encoding betalain related glucosyltransferase, such as Mirabilis. jalapa gene cyclo-DOPA 5-O-glucosyltransferase (cDOPA5GT), and their use for producing betalains. Finally, the invention provides chimeric polypeptides, expression vectors, cells, compositions, and organisms, including plants, and their uses in various methods of the invention.Type: GrantFiled: July 28, 2020Date of Patent: March 19, 2024Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.Inventors: Asaph Aharoni, Guy Polturak
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Patent number: 11932871Abstract: Methods of culturing T cells are provided. Accordingly there is provided a method of culturing T cells comprising culturing T cells in the presence of a T cell stimulator, an exogenous CCL21 and an exogenous ICAM1, thereby culturing the T cells. Also provided are cell cultures, isolated T cells and uses of same.Type: GrantFiled: March 2, 2018Date of Patent: March 19, 2024Assignees: YEDA RESEARCH AND DEVELOPMENT CO. LTD., THE MEDICAL RESEARCH, INFRASTRUCTURE AND HEALTH SERVICES FUND OF THE TEL AVIV MEDICAL CENTERInventors: Benjamin Geiger, Nir Friedman, Shimrit Lieber, Zelig Eshhar, Tova Waks, Anat Globerson Levin
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Publication number: 20240074473Abstract: A method of inducing multinucleated myotube formation is provided. The method comprising contacting myogenic precursor cells from a farmed animal with an Extracellular Regulated Signaling Kinase (ERK1/2) inhibitor and/or an upregulator of intracellular Ca 2+ and/or RXR/RAR agonists, enhancing fusion and myogenic maturation.Type: ApplicationFiled: November 6, 2023Publication date: March 7, 2024Applicant: Yeda Research and Development Co. Ltd.Inventors: Eldad TZAHOR, Ori PORAT-AVINOAM, Tamar Miriam Rose EIGLER-HIRSH
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Patent number: 11920162Abstract: Ex-vivo culture systems are provided. Accordingly there is provided a culture system comprising a culture medium and a precision-cut tissue slice placed on a tissue culture insert, wherein the precision-cut tissue slice is maintained in a highly oxygenated atmosphere containing at least 50% oxygen and wherein said culture is rotationally agitated facilitating intermittent submersion of the tissue slice in the culture medium. Also provided are methods of culturing a tissue and methods of using the culture system for selecting a drug for the treatment of a disease.Type: GrantFiled: April 3, 2018Date of Patent: March 5, 2024Assignee: Yeda Research and Development Co. Ltd.Inventors: Ravid Straussman, Nancy Gavert
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Patent number: 11920164Abstract: A culture medium is disclosed which comprises STAT3 activator, an ERK1/2 inhibitor and an Axin stabilizer, and optionally also a PKC inhibitor. Cell cultures comprising same and uses thereof are also disclosed.Type: GrantFiled: July 30, 2015Date of Patent: March 5, 2024Assignee: Yeda Research and Development Co. Ltd.Inventors: Yaqub Hanna, Noa Novershtern, Yoach Rais
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Publication number: 20240065988Abstract: A method of treating a psychiatric disorder in a subject in need thereof is disclosed. The method comprising administering to the subject a therapeutically effective amount of an N-methyl-D-aspartate (NMDA) receptor antagonist and a therapeutically effective amount of a KCNQ channel activator. Pharmaceutical compositions comprising an NMDA receptor antagonist and a KCNQ channel activator are also disclosed.Type: ApplicationFiled: October 5, 2023Publication date: February 29, 2024Applicants: Yeda Research and Development Co. Ltd., Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.Inventors: Alon CHEN, Juan Pablo LOPEZ
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Patent number: 11907835Abstract: Given an input image, an image enhancement task, and no external examples available to train on, an Image-Specific Deep Network is constructed tailored to solve the task for this specific image. Since there are no external examples available to train on, the network is trained on examples extracted directly from the input image itself. The current solution solves the problem of Super-Resolution (SR), whereas the framework is more general and is not restricted to SR.Type: GrantFiled: November 26, 2018Date of Patent: February 20, 2024Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.Inventors: Michal Irani, Assaf Shocher
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Publication number: 20240052038Abstract: The present specification discloses modified anti-PD-L1 antibodies that abolishes Fc-related effector function and enhances clearance rate while maintaining therapeutic efficacy for neurodegenerative disease modification. The present specification also discloses nucleic acid sequences and expression constructs encoding such modified anti-PD-L1 antibodies as well as methods of making such modified anti-PD-L1 antibodies. In addition, the present specification discloses methods of treatment and uses that employ an administration regime of the disclosed anti-PD-L1 antibodies that ensures the antibodies are present for only a specific period of time and then are sufficiently cleared from the body to ensure treatment efficacy is maintained.Type: ApplicationFiled: July 27, 2023Publication date: February 15, 2024Applicants: ImmunoBrain Checkpoint, Inc., Yeda Research and Development Co. LtdInventors: Ester Yoles, Berit Olsen Krogh, Allan Jensen, Jan Egebjerg, Carol David, Kuti Baruch, Michal Eisenbach-Schwartz
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Patent number: 11898220Abstract: A method for recovery of platinum group metals from a spent catalyst is described. The method includes crushing the spent catalyst to obtain a catalyst particulate material including particles having a predetermined grain size. The method includes subjecting the catalyst particulate material to a chlorinating treatment in the reaction zone at a predetermined temperature for a predetermined time period by putting the catalyst particulate material in contact with the chlorine containing gas. The method also includes applying an electromagnetic field to the chlorine-containing gas in the reaction zone to provide ionization of chlorine; thereby to cause a chemical reaction between platinum group metals and chlorine ions and provide a volatile platinum group metal-containing chloride product in the reaction zone. Following this, the volatile platinum group metal-containing chloride product is cooled to convert the product into solid phase platinum group metal-containing materials.Type: GrantFiled: October 3, 2019Date of Patent: February 13, 2024Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.Inventors: Igor Lubomirsky, Valery Kaplan
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Patent number: 11897884Abstract: This invention is directed to an aromatic material based free-standing film, a hybrid of organic crystalline materials and inorganic carbon nanomaterials, process of preparation and uses thereof. The film, which comprises a fibrous organic nanocrystals of an aromatic material, is mechanically and thermally stable. This film is optionally reinforced by hybridization with a reinforcement material, such as carbon nanotube, carbon material, a polysaccharide, a nanoclay a metal, metal alloy, or an organic polymer. The hybrid film of organic nanocrystals and carbon nanotubes (ONC/CNT) has high conductivity and high thermal stability. The films or hybrids of this invention are used as microfiltration membranes for various materials, in electrodes or perovskite solar cells.Type: GrantFiled: June 13, 2018Date of Patent: February 13, 2024Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.Inventors: Boris Rybtchinski, Haim Weissman, Tamar Wolf, Angelica Elkan, Sounak Dutta, Raja Bhaskar Kanth Siram