Patents Assigned to Yeda Research & Development Company Ltd.
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Patent number: 9957293Abstract: Conjugates of porphyrin, chlorophyll and bacteriochlorophyll photosensitizers with RGD-containing peptides or RGD peptidomimetics are provided that are useful for photodynamic therapy (PDT), particularly vascular-targeted PDT (VTP), of tumors and nonneoplastic vascular diseases such as age-related macular degeneration, and for diagnosis of tumors by different techniques.Type: GrantFiled: April 16, 2012Date of Patent: May 1, 2018Assignee: YEDA RESEARCH AND DEVELOPMENT COMPANY LTD.Inventors: Avigdor Scherz, Yoram Salomon, Efrat Rubinstein, Alexander Brandis, Doron Eren, Karin Neimann
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Patent number: 9164034Abstract: A device is presented comprising a multi-layer structure with a plurality of metal islands on the surface of a solid transparent substrate. The islands are coated by an ultrathin sol-gel derived silica film via self-assembled monolayer.Type: GrantFiled: June 5, 2009Date of Patent: October 20, 2015Assignee: YEDA RESEARCH AND DEVELOPMENT COMPANY LTD. AT THE WEIZMANN INSTITUTE OF SCIENCEInventors: Israel Rubinstein, Alexander Vaskevich, Irit Ruach-Nir, Tatyana Bendikov
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Patent number: 9006206Abstract: Described herein are compositions and methods for modulation of p53-dependent cell death and cell proliferation. The compositions are microRNAs and associated nucleic acids.Type: GrantFiled: May 19, 2014Date of Patent: April 14, 2015Assignees: Rosetta Genomics Ltd., Yeda Research and Development Company Ltd.Inventors: Moshe Oren, Nina Raver-Shapira, Efi Marciano, Yael Spector
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Publication number: 20140256789Abstract: Described herein are compositions and methods for modulation of p53-dependent cell death and cell proliferation. The compositions are microRNAs and associated nucleic acids.Type: ApplicationFiled: May 19, 2014Publication date: September 11, 2014Applicants: YEDA RESEARCH AND DEVELOPMENT COMPANY LTD., ROSETTA GENOMICS, LTD.Inventors: Moshe Oren, Nina Raver-Shapira, Efi Marciano, Yael Spector
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Patent number: 8802675Abstract: Multifunctional compounds are provided, comprising two or more functional moieties selected from: (i) a moiety that imparts an iron chelator function; (ii) a moiety that imparts a neuroprotective function; (iii) a moiety that imparts combined antiapoptotic, neuroprotective and/or neurorestorative functions; (iv) a moiety that imparts brain MAO inhibition, preferably with little or no MAO inhibition in liver and small intestine; (v) a moiety that imparts cholinesterase inhibitory function; and (vi) a moiety that imparts an N-methyl-D-aspartic acid receptor (NMDAR) inhibition, and pharmaceutically acceptable salts and optical isomers thereof. The multifunctional compounds are useful in the treatment or prevention of diseases, disorders or conditions that can be prevented and/or treated by iron chelation therapy, and/or neuroprotection and/or neurorestoration, and/or apoptosis inhibition and/or MAO inhibition and/or cholinesterase inhibition and/or NMADR inhibition.Type: GrantFiled: January 31, 2010Date of Patent: August 12, 2014Assignees: Technion Research and Development Foundation Ltd, Yeda Research and Development Company Ltd.Inventors: Moussa B. H. Youdim, Mati Fridkin, Hailin Zheng
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Patent number: 8797532Abstract: Measuring polarization profile along an input optical beam cross-section using an optical system includes a polarization beam splitting assembly for splitting the input beam into a predetermined number of beam components with a predetermined polarization relation between them, and including a polarization beam splitter in an optical path of the input beam splitting it into beam components having a polarization relationship and a birefringent element in an optical path of the beam components for splitting each of them into a pair of beams having ordinary and extraordinary polarizations, thereby producing the predetermined number of output beam components. The pixel matrix is located in substantially non-intersecting optical paths of the output beam components and generates a number of output data pieces indicative of intensity distribution within the output beam components and data contained therein being indicative of the polarization profile along the input beam cross-section.Type: GrantFiled: March 24, 2011Date of Patent: August 5, 2014Assignee: Yeda Research and Development Company Ltd.Inventors: Nir Davidson, Asher Friesem, Moti Fridman
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Publication number: 20140196180Abstract: A device is presented having reversibly changeable and optically readable optical properties. The device comprises a substrate having an electrically conductive surface and carrying a redox-active layer structure. The redox-active layer structure may be a monolayer or a multi-layer structure and is configured to have at least one predetermined electronic property including at least one of electrodensity and oxidation state. The electronic property of the layer structure defines an optical property of the structure thereby determining an optical response of the structure to certain incident light. This at least one electronic property is changeable by subjecting the redox-active layer structure to an electric field or to a redox-active material. The device thus enables effecting a change in said electronic property that results in a detectable change in the optical response of the layer structure.Type: ApplicationFiled: January 16, 2014Publication date: July 10, 2014Applicant: YEDA RESEARCH & DEVELOPMENT COMPANY LTD.Inventors: Milko E. VAN DER BOOM, Atindra D. Shukla, David Rosenblatt, Tarkeshwar Gupta
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Patent number: 8764953Abstract: The present invention relates to a system comprising a heat source to provide heat at the desired temperature and energy field (e.g. a solar concentrator); an electron source configured and operable to emit electrons; an electric field generator generating an electric field adapted to supply energy sufficient to dissociate gas molecules; and a reaction gas chamber configured and operable to cause interaction between the electrons with the molecules, such that the electrons dissociate the molecules to product compound and ions via dissociative electrons attachment (DEA) within the chamber.Type: GrantFiled: August 23, 2012Date of Patent: July 1, 2014Assignee: Yeda Research and Development Company Ltd.Inventors: Jacob Karni, Gidon Ferdiman, Yury Alioshin
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Patent number: 8765702Abstract: Described herein are compositions and methods for modulation of p53-dependent cell death and cell proliferation. The compositions are microRNAs and associated nucleic acids.Type: GrantFiled: February 26, 2008Date of Patent: July 1, 2014Assignees: Rosetta Genomics Ltd., Yeda Research and Development Company Ltd.Inventors: Moshe Oren, Nina Raver-Shapira, Efi Marciano, Yael Spector
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Patent number: 8722879Abstract: A device is presented having reversibly changeable and optically readable optical properties. The device comprises a substrate having an electrically conductive surface and carrying a redox-active layer structure. The redox-active layer structure may be a monolayer or a multi-layer structure and is configured to have at least one predetermined electronic property including at least one of electrodensity and oxidation state. The electronic property of the layer structure defines an optical property of the structure thereby determining an optical response of the structure to certain incident light. This at least one electronic property is changeable by subjecting the redox-active layer structure to an electric field or to a redox-active material. The device thus enables effecting a change in said electronic property that results in a detectable change in the optical response of the layer structure.Type: GrantFiled: March 5, 2007Date of Patent: May 13, 2014Assignee: Yeda Research & Development Company Ltd. at the Weizmann Institute of ScienceInventors: Milko E. Van Der Boom, Atindra D. Shukla, David Rosenblatt, Tarkeshwar Gupta
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Patent number: 8723514Abstract: The present invention discloses a novel magnetic sensor device performing direct magnetic field imaging, comprising a probe having a conical tip portion which is configured as a sensor having two superconductors separated by a thin non-superconducting layer (such as a Josephson junction based sensor), where the non-superconducting layer is located at the apex portion of said conical tip, thereby defining electron tunneling region(s) at said apex portion. The technique of the present invention enables the sensor device to be very small and to be brought very close to the sample surface.Type: GrantFiled: June 26, 2008Date of Patent: May 13, 2014Assignee: Yeda Research and Development Company Ltd.Inventors: Amit Finkler, Jens Martin, Yuri Myasoedov, Yehonathan Segev, Amir Yacoby, Eli Zeldov
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Patent number: 8529988Abstract: A method is presented for use in fabrication of metal islands on an oxide substrate. The method comprises: depositing a selected metal on the oxide substrate by evaporation of said selected metal; and annealing a film of the selected metal on said substrate at temperatures including an annealing temperature being less than 50° C. lower than a glass transition temperature, thereby forming the metal islands partially embedded in said substrate.Type: GrantFiled: April 7, 2009Date of Patent: September 10, 2013Assignee: Yeda Research and Development Company Ltd.Inventors: Israel Rubinstein, Alexander Vaskevich, Tatyana Karakouz
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Patent number: 8518364Abstract: A nanostructure, being either an Inorganic Fullerene-like (IF) nanostructure or an Inorganic Nanotube (INT), having the formula A1?x-Bx-chalcogenide are described. A being a metal or transition metal or an alloy of metals and/or transition metals, B being a metal or transition metal B different from that of A and x being ?0.3. A process for their manufacture and their use for modifying the electronic character of A-chalcogenide are described.Type: GrantFiled: November 7, 2012Date of Patent: August 27, 2013Assignee: Yeda Research and Development Company Ltd.Inventors: Reshef Tenne, Francis Leonard Deepak, Hagai Cohen, Sidney R. Cohen, Rita Rosentsveig, Lena Yadgarov
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Patent number: 8507853Abstract: The present invention relates to a novel system and method for the determination of depth profiling with improved accuracy and reliability. The method comprises obtaining spectroscopic data from the sample while under at least two different electrical conditions of the sample, the spectroscopic data comprising a signal of charged particles emitted from the sample, and being indicative of a change in amplitude, spectral position and spectral shape of the signal from the sample while under different electrical conditions of the sample, the change being indicative of the compositional profile and spatial distribution for at least one chemical element in the sample along a direction through the sample.Type: GrantFiled: October 22, 2009Date of Patent: August 13, 2013Assignee: Yeda Research and Development Company Ltd.Inventor: Hagai Cohen
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Publication number: 20130109601Abstract: A nanostructure, being either an Inorganic Fullerene-like (IF) nanostructure or an Inorganic Nanotube (INT), having the formula A1?x-Bx-chalcogenide are described. A being a metal or transition metal or an alloy of metals and/or transition metals, B being a metal or transition metal B different from that of A and x being ?0.3. A process for their manufacture and their use for modifying the electronic character of A-chalcogenide are described.Type: ApplicationFiled: November 7, 2012Publication date: May 2, 2013Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY LTD.Inventor: Yeda research and development company ltd.
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Patent number: 8419984Abstract: A film is presented having super-pyroelectric properties. The film comprises nano-sized grains being in a ferroelectric phase and having at least three different crystallographic variants defining at least two polycrystalline macro-domains. The film is shaped to define at least one film region with the macro-domains of a predetermined shape and different orientations of crystallographic axes with respect to the film's surface, thereby enabling to apply a temperature change to the film to induce movement of the polycrystalline macro-domains boundaries enabling super-pyroelectric properties.Type: GrantFiled: June 17, 2007Date of Patent: April 16, 2013Assignees: Yeda Research and Development Company Ltd., University of MarylandInventors: Igor Lubomirsky, Vera Lyahovitsky, Alexander L. Roytburd
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Publication number: 20130087182Abstract: A solar energy conversion system is presented. The system comprises at least one waveguide arrangement having at least one light input respectively. The waveguide arrangement comprises a core unit for passing input solar radiation therethrough and a cladding material arrangement interfacing with the core therealong. The cladding material arrangement is configured as an array of spaced-apart solar cells arranged along the core unit and having different optical absorption ranges, such that an interface between the waveguide core and the cladding arrangement spectrally splits the photons of the input solar radiation by causing the photons of different wavelengths, while passing through the core unit, to be successively absorbed and thereby converted into electricity by the successive solar cells of said array.Type: ApplicationFiled: November 29, 2012Publication date: April 11, 2013Applicants: BAR ILAN UNIVERSITY, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.Inventors: Bar Ilan University, Yeda Research and Development Company, Ltd., The Regents of the University of California
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Publication number: 20130043138Abstract: The present invention relates to a system comprising a heat source to provide heat at the desired temperature and energy field (e.g. a solar concentrator); an electron source configured and operable to emit electrons; an electric field generator generating an electric field adapted to supply energy sufficient to dissociate gas molecules; and a reaction gas chamber configured and operable to cause interaction between the electrons with the molecules, such that the electrons dissociate the molecules to product compound and ions via dissociative electrons attachment (DEA) within the chamber.Type: ApplicationFiled: August 23, 2012Publication date: February 21, 2013Applicant: Yeda Research and Development Company Ltd.Inventors: Jacob KARNI, Gidon Ferdiman, Yury Alioshin
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Patent number: 8354583Abstract: A solar energy conversion system is presented. The system comprises at least one waveguide arrangement having at least one light input respectively. The waveguide arrangement comprises a core unit for passing input solar radiation therethrough and a cladding material arrangement interfacing with the core therealong. The cladding material arrangement is configured as an array of spaced-apart solar cells arranged along the core unit and having different optical absorption ranges, such that an interface between the waveguide core and the cladding arrangement spectrally splits the photons of the input solar radiation by causing the photons of different wavelengths, while passing through the core unit, to be successively absorbed and thereby converted into electricity by the successive solar cells of said array.Type: GrantFiled: May 30, 2007Date of Patent: January 15, 2013Assignees: Bar Ilan University, Yeda Research and Development Company Ltd, The Regents of The University of CaliforniaInventors: Arie Zaban, David Cahen, Igor Lubomirsky, Oscar M. Stafsudd
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Patent number: 8329138Abstract: A nanostructure, being either an Inorganic Fullerene-like (IF) nanostructure or an Inorganic Nanotube (INT), having the formula A1?x-Bx-chalcogenide are described. A being a metal or transition metal or an alloy of metals and/or transition metals, B being a metal or transition metal B different from that of A and x being ?0.3. A process for their manufacture and their use for modifying the electronic character of A-chalcogenide are described.Type: GrantFiled: March 10, 2010Date of Patent: December 11, 2012Assignee: Yeda Research and Development Company Ltd.Inventors: Reshef Tenne, Francis Leonard Deepak, Hagai Cohen, Sidney R. Cohen, Rita Rosentsveig, Lena Yadgarov