Patents Assigned to Yeda Research & Development Company Ltd.
  • Patent number: 4732811
    Abstract: There are provided magnetic and non-magnetic agarose and agar polyaldehyde beads with diameters ranging from 40 microns up to 1 cm, and processes for the synthesis of such beads. The polyaldehyde compounds e.g. polyacrolein, polymethacrolein or polyglutaraldehyde, were used as microspheres or as powders. The agarose-polyaldehyde beads are capable of covalently binding in a single step, through their aldehyde groups, compounds containing primary amino groups of thiol groups, such as proteins, antibodies, enzymes and drugs. The beads are useful for various biological applications e.g. affinity chromatography, hemoperfusion, ion exchange resins, cell labeling, diagnostic purposes and cell separation.
    Type: Grant
    Filed: October 22, 1986
    Date of Patent: March 22, 1988
    Assignee: Yeda Research and Development Company, Ltd.
    Inventor: Shlomo Margel
  • Patent number: 4649218
    Abstract: The present inveniton relates to novel lithium ionophores, to a process for producing such lithium ionophores and to their uses as pharmaceutical compositions, electrodes and as components of batteries.
    Type: Grant
    Filed: January 14, 1981
    Date of Patent: March 10, 1987
    Assignee: Yeda Research and Development Company Ltd.
    Inventors: Abraham Shanzer, David Samuel
  • Patent number: 4634590
    Abstract: Compositions for the prevention of, and for the treatment of autoimmune diseases which comprise as active ingredient membrane material shed from autoimmune T lymphocytes, or T lymphocytes activated by a pressure application and release process. There is also provided a process for obtaining such active materials and for preparing pharmaceutical compositions for these.
    Type: Grant
    Filed: September 7, 1984
    Date of Patent: January 6, 1987
    Assignee: Yeda Research and Development Company Ltd.
    Inventors: Irun R. Cohen, Meir Shinitzky
  • Patent number: 4622292
    Abstract: An assay and kit for the detection and quantitative determination of interferon. The assay is based on the exposure of certain cells to a solution containing the interferon which is to be determined, infecting the cells with a certain virus, incubating for a predetermined period of time, lysing the infected cultures and determining the virus protein. The measurement of the virus proteins can be effected by ELISA or radioimmunoassay.
    Type: Grant
    Filed: August 22, 1983
    Date of Patent: November 11, 1986
    Assignee: Yeda Research and Development Company Ltd.
    Inventors: Michel Revel, David Wallach
  • Patent number: 4621135
    Abstract: Novel peptide materials having thymic humoral activity are disclosed having the respective amino acid sequences of:Leu-Glu-Asp-Gly-Pro-Lys-Phe-Leu;His-Pro-Leu-Pro-Asp-Leu-Tyr; andPhe-Val-LeuThese novel peptides can be isolated from natural thymus glands or can be prepared synthetically.
    Type: Grant
    Filed: June 6, 1985
    Date of Patent: November 4, 1986
    Assignee: Yeda Research & Development Company, Ltd.
    Inventors: Nathan Trainin, Yigal Burstein
  • Patent number: 4609740
    Abstract: The invention relates to derivatives of fluorescein and to their production. The compounds are of value in determining the intracellular pH. Thus there may be obtained fluorescent living cells with a comparatively stable level of fluorescence. The novel fluorescein compounds can be used for other labelling purposes in biology and biochemistry.
    Type: Grant
    Filed: May 20, 1982
    Date of Patent: September 2, 1986
    Assignee: Yeda Research and Development Company Ltd.
    Inventor: Avner Rotman
  • Patent number: 4602843
    Abstract: An optically-generated or computer-generated holographic diffusing screen usable in bringing an image to focus thereon is a hologram which upon reconstruction displays a substantially transparent annulus on a substantially opaque background. The annulus preferably has an outer diameter substantially equal to the exit pupil of the image-forming lens, which image is to be focused. The radial width of the transparent annular portion is very small relative to the outer diameter of the annulus. The holographic diffusion screen may be formed by making a holographic image of the substantially annular pattern or by exposing a holographic plate with two collimated mutually coherent beams of light, one beam being perpendicular to the plate while the other is at an angle with respect to the first beam, rotating the holographic recording plate a predetermined amount, and repeating the exposing and rotating steps until a predetermined number of exposures has been completed.
    Type: Grant
    Filed: December 3, 1982
    Date of Patent: July 29, 1986
    Assignee: Yeda Research and Development Company, Ltd.
    Inventor: Isaia Glaser-Inbari
  • Patent number: 4533506
    Abstract: A process for resolution of a mixture of D- and L- amino acids, selected from threonine (THR), asparagine (ASN), p-hydroxyphenylglycine p-toluene sulfonate (pHPGpTS) and glutamic acid hydrochloride (GLU), which crystallize in the form of a conglomerate, whereby the ratio of one desired enantiomorph to the other undesired enantiomorph of said amino acid is increased in the crystalline compound obtained, as compared to the ratio in the starting material, which process comprises forming a supersaturated solution of said mixture, adding another predetermined amino acid as additive, which has a molecular structure which resembles that of one of the enantiomers of said racemic mixture, said additive being a D-amino acid as an inhibitor of the growing D-amino acid when the L-amino acid is desired, or a L-amino acid when the D-amino acid is desired, and crystallizing part of the compound from said supersaturated solution. When GLU.
    Type: Grant
    Filed: January 3, 1983
    Date of Patent: August 6, 1985
    Assignee: Yeda Research and Development Company Ltd.
    Inventors: Meir Lahav, Lia Addadi, Isabela Weissbuch
  • Patent number: 4533252
    Abstract: A portable device for photoacoustic spectroscopy of plants and other photosynthetic tissues, cells and organelles is provided. There is further provided a method of measuring photosynthesis of such tissues, cells and organelles.
    Type: Grant
    Filed: May 25, 1982
    Date of Patent: August 6, 1985
    Assignee: Yeda Research and Development Company Ltd.
    Inventors: David Cahen, Shmuel Malkin, Benjamin Horwitz, Gerard Bults
  • Patent number: 4532220
    Abstract: There is provided an assay for the determination of the carcinogenicity of chemical and physical agents, by exposing a selected line of tumor virus transformed cells to the agent to be tested and determining whether such exposure induces endogenous viral DNA replication in such cells, which induction is indicative of the carcinogenicity of the tested agent by in situ hybridization. There is provided a kit for carrying out such assay.
    Type: Grant
    Filed: March 23, 1982
    Date of Patent: July 30, 1985
    Assignee: Yeda Research and Development Company Ltd.
    Inventor: Sara Lavi
  • Patent number: 4527567
    Abstract: An extra-corporeal, self-contained, on-line, beat-to-beat pacemaker function analyzer (PFA) for automatic evaluation and indication of the quality of performance of cardiac pacing systems implanted in place for: routine examination of ambulatory patients; long-term surveillance of hospitalized patients; and examination of ECG traces (including pacing artefacts) of remote pacemaker patients, transferred by telephone or radio to a central follow-up station. The PFA provides a comprehensive examination of asynchronous, demand and demand-hysteresis pacemakers of all makes, including the state of the pacemaker's battery, the intactness of the electronic circuitry and of the electrodes, and the proper location of the electrodes in the heart.
    Type: Grant
    Filed: July 26, 1982
    Date of Patent: July 9, 1985
    Assignee: Yeda Research & Development Company, Ltd.
    Inventors: Henryk Fischler, Yaakov Krupka, Salamon Behar
  • Patent number: 4484418
    Abstract: There is provided a scaife for the polishing of gemstones wherein the abrasive material is embedded in a matrix of a material maintained in the solid state, which material has a high enthalpy of phase transition from solid to liquid. Suitable materials are frozen water, frozen water/organic liquid mixtures such as water/alkanol mixtures and suitable metals or metal alloys. There is also provided a process for the polishing of gemstones which comprises establishing a layer of abrasive embedded in a suitable solid matrix in or on the surface of a rotatory plate and polishing the gemstones, overheating being prevented by the high enthalpy of solid/liquid transition of the said matrix.
    Type: Grant
    Filed: May 23, 1983
    Date of Patent: November 27, 1984
    Assignee: Yeda Research & Development Company, Ltd.
    Inventors: Shymon Reich, David Vofsi
  • Patent number: 4478699
    Abstract: A device for the photosynthetic reduction of carbon dioxide and water by sunlight to formic acid, formaldehyde and methanol in the presence of semiconducting photoactive materials. Using preferred compositions of photoactive materials, selected from oxides and sulfides of copper, iron, molybdenum, ruthenium, lead, titanium, and from mixtures of any of these, and from barium titanate, calcium titanate, and strontium titanate, this photochemical solar collector also achieves photothermal energy conversion, thus providing the energy required for continuous distillation and recovery of the above organic materials produced.
    Type: Grant
    Filed: April 22, 1981
    Date of Patent: October 23, 1984
    Assignee: Yeda Research & Development Company, Ltd.
    Inventors: Martin M. Halmann, Mira Ulman, Benedict Aurian-Blajeni
  • Patent number: 4478770
    Abstract: The invention relates to a process for the production of a contact lens, which comprises coating a tool made of an inert material, having a curvature corresponding to that of one of the optical surfaces of the lens to be produced, with a layer of solid polymer, and machining the outer surface of said polymer to the desired curvature of the second surface of said lens while supported by said tool, and to a tool for carrying out such process.
    Type: Grant
    Filed: May 17, 1982
    Date of Patent: October 23, 1984
    Assignee: Yeda Research and Development Company, Ltd.
    Inventors: David Vofsi, Shymon Reich, Israel Tchoukran, Joaquin Mayoral
  • Patent number: 4415500
    Abstract: A catalyst for use in homogeneous catalysis comprises a backbone of at least 5 carbon atoms chain length, which may comprise aromatic moieties and also hetero atoms, a polar moiety at one of the ends of the backbone and a ligand moiety at its other end, such ligand moiety being adapted to form a complex with a metal ion. A process of hydrogenation or of hydroformylation comprises contacting an aqueous phase containing a catalyst as defined above, with an organic phase comprising the reactant, introducing hydrogen or a hydrogen-carbon monoxide mixture with agitation until the reaction is terminated, separating the phases and recovering the desired reaction products from the organic phase.
    Type: Grant
    Filed: March 3, 1981
    Date of Patent: November 15, 1983
    Assignee: Yeda Research and Development Company Ltd.
    Inventors: Joost Manassen, Yaakov Dror
  • Patent number: 4390722
    Abstract: A process for resolution of a mixture of D- and L- amino acids, selected from threonine (THR), asparagine (ASN), p-hydroxyphenylglycine p-toluene sulfonate (pHPGpTS) and glutamic acid hydrochloride (GLU), which crystallize in the form of a conglomerate, whereby the ratio of one desired enantiomorph to the other undesired enantiomorph of said amino acid is increased in the crystalline compound obtained, as compared to the ratio in the starting material, which process comprises forming a supersaturated solution of said mixture, adding another predetermined amino acid as additive, which has a molecular structure which resembles that of one of the enantiomers of said racemic mixture, said additive being a D-amino acid as an inhibitor of the growing D-amino acid when the L-amino acid is desired, or a L-amino acid when the D-amino acid is desired, and crystallizing part of the compound from said supersaturated solution. When GLU.
    Type: Grant
    Filed: June 1, 1981
    Date of Patent: June 28, 1983
    Assignee: Yeda Research and Development Company Ltd.
    Inventors: Meir Lahav, Lia Addadi, Isabela Weissbuch
  • Patent number: 4338194
    Abstract: Methods of producing solute-rejecting dynamic membrane filters are described comprising depositing a bed of fumed silica particles on a porous substrate having a pore size of 0.025-3 microns, the silica particles being substantially spherical and uniform and having a nominal particle diameter of 20-80 A.
    Type: Grant
    Filed: June 5, 1978
    Date of Patent: July 6, 1982
    Assignee: Yeda Research & Development Company Ltd.
    Inventor: Gerald Tanny
  • Patent number: 4325727
    Abstract: Phosphonoacetals of the formula ##STR1## wherein R.sup.1 is an alkyl group having from 1-3 carbon atoms;R.sup.2 is a hydrogen atom or a cation such as NH.sub.4.sup.+, Na.sup.+, K.sup.+, Ca.sup.2+, Sn.sup.2+, Zn.sup.2+, Cd.sup.2+, Cu.sup.2+, and R.sup.1 ;n is an integer from 0 to 2;q is an integer from 1 to 3;R.sup.3 is a residue of a polyhydroxy compound having from 2-12 carbon atoms;Y and Y.sup.1 are each selected from the group consisting of hydrogen atoms, hydroxyl groups, carbinol groups, methyl halogens, methyl carbamoyls.
    Type: Grant
    Filed: May 8, 1979
    Date of Patent: April 20, 1982
    Assignee: Yeda Research and Development Company, Ltd.
    Inventors: David Vofsi, Martin M. Halmann, Shaul Yanai
  • Patent number: 4309257
    Abstract: The invention relates to a process for the production of optically selective surfaces for use in solar collectors, having a predetermined ratio of absorbance .alpha..sub.s to emmitance .epsilon. of at least 10, which comprises effecting an anodic oxidation of copper, or copper applied to any substrate metal, in an alkaline bath at an elevated temperature between 50.degree. and 85.degree. C., preferably 70.degree. to 85.degree. C., and at a current density of above 1 mA/cm.sup.2 and up to 40 mA/cm.sup.2 until an increase of resistance is experienced. Substrate metals may be copper, copper plated steel, copper plated galvanized iron, copper plated nickel, nickel plated steel to which a layer of copper is applied, and the like.
    Type: Grant
    Filed: September 4, 1980
    Date of Patent: January 5, 1982
    Assignee: Yeda Research & Development Company Ltd.
    Inventors: Michael Epstein, Israel Dostrovsky
  • Patent number: 4298384
    Abstract: The present invention relates to antifouling paints for marine use comprising a conventional paint base containing as active ingredient a compound of the formula ##STR1## wherein X is selected from chlorine and bromine,Y is selected from hydrogen and lower alkyl, andZ is selected from --COOR wherein R is lower alkyl, and --CN, possibly in combination with a conventional antifouling agent, and to the protection of marine structures and marine vessels which comprises applying such an antifouling paint to such structures and vessels.
    Type: Grant
    Filed: July 18, 1979
    Date of Patent: November 3, 1981
    Assignee: Yeda Research and Development Company, Ltd.
    Inventors: Yael Allingham, David Vofsi