Patents Assigned to Yeda Research & Development
  • Publication number: 20240029819
    Abstract: Agents binding modified antigen dependent peptides and use of same are provided. Accordingly, there is provided an agent capable of specifically binding an MHC presented peptide comprising a post translational modification (PTM), wherein the agent does not bind a peptide having the same amino acid sequence as said peptide but does not comprise said modification. Also provided are polynucleotides encoding the agent, cells expressing same and methods of use thereof. Also provided is a computer implemented method for generating a dataset of PTM on MHC bound peptides.
    Type: Application
    Filed: April 27, 2023
    Publication date: January 25, 2024
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Yifat MERBL, Assaf KACEN, Yishai LEVIN, David MORGENSTERN
  • Publication number: 20240026262
    Abstract: Methods and devices for ex-utero mouse embryonic development are provided. Accordingly, there is provided a method of ex-utero culturing a mouse embryo at a zygote stage under conditions that allow developments of the embryo to organogenesis or any developmental stage therein-between. Also provided a fetal incubation system, and methods of using same.
    Type: Application
    Filed: September 18, 2023
    Publication date: January 25, 2024
    Applicant: Yeda Research and Development Co. Ltd.
    Inventor: Yaqub HANNA
  • Publication number: 20240026357
    Abstract: A composition of matter comprising a synthetic miR-135 molecule comprising a nucleic acid sequence of a miR-135b as set forth in SEQ ID NO: 37, and a complementary strand as set forth in SEQ ID NO: 40 is disclosed. A conjugate comprising a composition of matter comprising a synthetic miR-135 molecule and a cell-targeting moiety is also disclosed.
    Type: Application
    Filed: July 14, 2023
    Publication date: January 25, 2024
    Applicants: Yeda Research and Development Co. Ltd., miCure Therapeutics Ltd.
    Inventors: Alon CHEN, Sharon MANASHIROV, Andres Pablo MONTEFELTRO
  • Patent number: 11873322
    Abstract: A recombinant system for improving genome editing via homologous recombination is disclosed. The system comprising a first nucleic acid sequence encoding a DNA editing agent having a double strand DNA cutting activity and a second nucleic acid sequence encoding a polypeptide capable of increasing homologous recombination in a target cell.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: January 16, 2024
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Yosef Shaul, Nina Reuven
  • Publication number: 20240009287
    Abstract: A vaccine comprising a pharmaceutically acceptable carrier and bacteria which presents at least one cancer-associated antigen is disclosed. The bacteria are not genetically modified to express the at least one cancer-associated antigen. Uses thereof are also disclosed.
    Type: Application
    Filed: August 17, 2023
    Publication date: January 11, 2024
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Ravid STRAUSSMAN, Oded SANDLER, Reut RIFF
  • Publication number: 20240009286
    Abstract: A vaccine comprising tumor-homing bacteria which are genetically modified to express at least one cancer-associated antigen and a pharmaceutically acceptable carrier is disclosed. Uses thereof are also disclosed.
    Type: Application
    Filed: August 17, 2023
    Publication date: January 11, 2024
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Ravid STRAUSSMAN, Oded SANDLER, Reut RIFF
  • Publication number: 20240009315
    Abstract: Particles having an ACE2 targeting moiety attached to an outer surface thereof are disclosed herein. The ACE2 targeting moiety comprises a polypeptide comprising an amino acid sequence of SARS CoV-2 receptor-binding domain (RBD), wherein said amino acid sequence comprises a modification at position 358 and at least two additional modifications at two positions selected from the group consisting of 484, 498 and 501. Uses of the particles for treatment and diagnosis of diseases are also disclosed.
    Type: Application
    Filed: August 2, 2023
    Publication date: January 11, 2024
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Gideon SCHREIBER, Jiri ZAHRADNIK, Amnon BAR-SHIR, Yinon RUDICH, Andrea GALISOVA
  • Publication number: 20240010973
    Abstract: Methods of generating a synthetic embryo are provided. Accordingly, there is provided a method of generating a synthetic embryo comprising inducing expression of a factor that induces differentiation to trophectoderm cells in a subpopulation of naïve pluripotent stem cells (PSCs) to obtain a trophectoderm primed cells; inducing expression of a factor that induces differentiation to extra embryonic primitive endodermal cells in a second subpopulation of naïve PSCs to obtain extra embryonic primitive endodermal primed cells; and mixing said trophectoderm primed cells and said extra embryonic primitive endodermal primed cells with naïve PSCs under conditions that allow formation of aggregated cells. Also provided are articles of manufactures, mixtures and aggregates of cells and methods of using same.
    Type: Application
    Filed: July 27, 2023
    Publication date: January 11, 2024
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Yaqub HANNA, Sergey VIUKOV, Emilie WILDSCHUTZ, Noa NOVERSHTERN, Carine JOUBRAN, Segev NAVEH TASSA, Alejandro CASTREJON AGUILERA, Bernardo OLDAK, Shadi TARAZI, Francesco RONCATO
  • Patent number: 11865184
    Abstract: A method of targeting a pharmaceutical agent to a senescent cell is disclosed. The method comprises administering the pharmaceutical agent to the subject, wherein said pharmaceutical agent is attached to an affinity moiety, said affinity moiety being capable of binding specifically to a polypeptide selected from the group consisting of HSP90B1, DNAJB4, PI4K2A, DBN1, PRKCSH, SPTBN1, NPM1, ITGA3 and a polypeptide set forth in Table 1. The targeting may be for therapeutics or diagnostics.
    Type: Grant
    Filed: October 21, 2020
    Date of Patent: January 9, 2024
    Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Valery Krizhanovsky, Yossi Ovadya
  • Patent number: 11859080
    Abstract: This invention is directed to composites and films comprising hydroxyapatite, biodegradable polymer, a biocompatible surfactant with inorganic fullerene-like (IF) nanoparticles or inorganic nanotubes (INT); methods of preparation and uses thereof.
    Type: Grant
    Filed: November 1, 2021
    Date of Patent: January 2, 2024
    Assignees: YEDA RESEARCH AND DEVELOPMENT CO. LTD., HOLON ACADEMIC INSTITUTE OF TECHNOLOGY
    Inventors: Reshef Tenne, Hila Shalom, Lev Rapoport, Ofek Golan
  • Publication number: 20230415378
    Abstract: The presently disclosed subject matter relates to the field of electrospun epoxy fibers, a solution for producing the fibers and a system for electrospinning the fibers. This invention further relates to processes of producing the solution and the fibers. By dissolving epoxy in a dielectric solvent, suitable electrospinning conditions are achieved by controlling the degree of epoxy crosslinking in the solution. The fibers are captured on a net screen, with the positive electrode placed behind it. The resulting electrospun fibers exhibit superior mechanical properties in comparison with other epoxy fibers. This improvement in mechanical properties is, in part, due to anisotropic molecular rearrangement resulting from the strong stretching forces induced by electrospinning.
    Type: Application
    Filed: October 26, 2022
    Publication date: December 28, 2023
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Daniel Hanoch WAGNER, Mark SHNEIDER
  • Publication number: 20230419149
    Abstract: A quantum computing system comprises a plurality of photonic cavities, a plurality of coupling locations for quantum emitter positioning, a photon generator configured to supply photons to the plurality of photonic cavities, and a plurality of photon output channels downstream of the plurality of cavities to output a graph state. Each coupling location is associated with a differing one of the plurality of photonic cavities. Quantum emitters associated with each coupling location are configured to mediate interactions between consecutive incoming photonic qubits to generate the graph state, and the photonic cavities are configured to couple photonic qubits to the quantum emitters.
    Type: Application
    Filed: April 13, 2023
    Publication date: December 28, 2023
    Applicants: QUANTUM SOURCE LABS LTD., YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Gil SEMO, Ziv AQUA, Oded MELAMED, Dan CHARASH, Serge ROSENBLUM, Barak DAYAN
  • Publication number: 20230419150
    Abstract: A quantum computing system, method and computer readable storage medium involve tuning a whispering-gallery mode optical resonator to support a resonance frequency associated with a transition frequency of an atom. Operation of a laser is controlled to cause the atom to be trapped adjacent the optical resonator and within the evanescent field portion. Based on an atom presence signal from an optical atom presence detector, an indication is provided that the atom is trapped adjacent the optical resonator. A frequency of a cooling laser is controlled to cool the atom, and the optical resonator is configured to define a closed loop-like mode including an evanescent field portion. The trapping laser is configured to cause the atom to be trapped adjacent the whispering-gallery mode resonator, and the cooling laser is configured to manipulate a state of the atom to thereby cool the atom.
    Type: Application
    Filed: April 14, 2023
    Publication date: December 28, 2023
    Applicants: QUANTUM SOURCE LABS LTD., YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Gil SEMO, Ziv AQUA, Oded MELAMED, Dan CHARASH, Serge ROSENBLUM, Barak DAYAN
  • Patent number: 11852634
    Abstract: The present invention relates to uses of a peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, analogues and derivatives thereof, for the treatment of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). The present invention further provides a method for assessing responsiveness to treatment with the peptide of the invention. In addition, the present invention relates to prognosis of ALS progression, using Akt and phosphorylated Akt as biomarkers.
    Type: Grant
    Filed: October 27, 2020
    Date of Patent: December 26, 2023
    Assignees: Yeda Research and Development Co. Ltd., Universitätsklinikum Hamburg-Eppendorf
    Inventors: Eran Ovadia, Irun R. Cohen, Johannes Herkel, Raanan Margalit, Meirav Pevsner-Fischer
  • Publication number: 20230407492
    Abstract: This invention provides a catalytic process wherein alternating current is used for catalytic coupling (such as C—C, C—N, C—O, C—S, C—P, C—Si and/or C—B couplings) using a transition-metal catalysis.
    Type: Application
    Filed: September 14, 2021
    Publication date: December 21, 2023
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Sergey N. SEMENOV, Evgenii BORTNIKOV
  • Publication number: 20230406837
    Abstract: Provided herein are Sulfamate compounds for use in modulating an activity of peptidyl-prolyl isomerase NIMA-interacting-1 (Pin1).
    Type: Application
    Filed: June 14, 2023
    Publication date: December 21, 2023
    Applicant: Yeda Research and Development Co., Ltd.
    Inventors: Nir LONDON, Rambabu Reddi
  • Patent number: 11847535
    Abstract: A quantum computing system includes a first silicon nitride resonator couplable to a first alkali atom, a second silicon resonator couplable to a second alkali atom, and a plurality of lasers for trapping, cooling, and manipulating the first alkali atom and the second alkali atom. Detectors detect a presence of the trapped first alkali atom and the trapped second alkali atom, and a processor is configured to receive at least one input signal from at least one of the detectors, the input signal indicating a presence of the trapped first alkali atom and the trapped second alkali atom, and, based on the received input, control at least some of the plurality of lasers to manipulate at least one of the trapped first alkali atom and the trapped second alkali atom to thereby generate photonic qubits using the trapped first alkali atom or generate entanglement between photonic qubits transmitted to the trapped second alkali atom.
    Type: Grant
    Filed: April 14, 2023
    Date of Patent: December 19, 2023
    Assignees: Yeda Research and Development Co. Ltd., Quantum Source Labs Ltd.
    Inventors: Gil Semo, Ziv Aqua, Oded Melamed, Dan Charash, Serge Rosenblum, Barak Dayan
  • Patent number: 11844827
    Abstract: An isolated cell having a central memory T-lymphocyte (Tcm) phenotype, the cell being tolerance-inducing cell and capable of homing to the lymph nodes following transplantation, the cell being transduced to express a cell surface receptor comprising a T cell receptor signaling module is disclosed. Methods of generating same and using same are also disclosed.
    Type: Grant
    Filed: November 22, 2021
    Date of Patent: December 19, 2023
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Yair Reisner, Noga Or-Geva, Eran Ophir, Yaki Eidelstein, Rotem Gidron Budovsky
  • Patent number: 11846636
    Abstract: Methods and kits for diagnosing systemic lupus erythematosus (SLE) in a subject are provided. Particularly, the present invention relates to specific oligonucleotide antibody reactivities useful in diagnosing SLE in a subject.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: December 19, 2023
    Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Irun R. Cohen, Eytan Domany, Noam Shental, Ittai Fattal
  • Publication number: 20230398214
    Abstract: Methods of generating an isolated population of non-graft versus host disease (GVHD) inducing cells comprising a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation, are disclosed. Cells generated by the methods, pharmaceutical compositions and methods of treatment are also disclosed.
    Type: Application
    Filed: August 6, 2020
    Publication date: December 14, 2023
    Applicants: Yeda Research and Development Co. Ltd., Board of Regents, The University of Texas System
    Inventors: Yair REISNER, Esther BACHAR-LUSTIG, Assaf LASK, Noga OR-GEVA, Rotem GIDRON BUDOVSKY, Rakefet SIDLIK MUSKATEL