Abstract: Liposomal bupivacaine compositions are prepared using an ammonium sulfate gradient loading procedure, at a pH which prevents precipitation of the drug from the loading solution. Also described are liposome suspensions comprising `GMV` (giant multivesicular) liposomes and methods for their preparation. The liposomal compositions are characterized by high drug-to-lipid ratios and provide long term analgesia.
Type:
Grant
Filed:
August 11, 1999
Date of Patent:
December 19, 2000
Assignees:
New York University, Yissum Research Development Co. of the Hebrew Univ. of Jerusalem
Inventors:
Elijah M. Bolotin, Gilbert J. Grant, Yechezkel Barenholz, Herman Turndorf, Boris Piskoun
Abstract: The invention relates to synthetic phosphorothioated or partially phosphorothioated oligodeoxynucleotides capable of selectively modulating hemopoietic bone marrow cells development. More particularly, the invention relates to synthetic antisense oligodeoxynucleotides directed against a region spanning the AUG initiation condon in human ACHE or 2HS genes, having phosphorothioate bonds linking between the nucleotide bases; synthetic antisense oligodeoxynucleotides directed against a region spanning the AUG initiation condon in human ACHE gene, 2HS gene or BCHE gene or against a 5'-region in the human CHED (cdc2 homolog) gene, having phosphorothioate bonds linking between the four 3'-terminus nucleotide bases. The invention also relates to pharmaceutical compositions comprising as active ingredient at least one synthetic phosphorothioated or partially phosphorothioated antisense oligodeoxynucleotides according to the invention in physiologically acceptable carrier in diluent.
Type:
Grant
Filed:
December 1, 1994
Date of Patent:
April 6, 1999
Assignee:
Yissum Research Development Co. of the Hebrew Univ. of Jerusalem
Inventors:
Hermona Soreq, Haim Zakut, Fritz Eckstein
Abstract: The invention provides a dry, disposable, polymeric product having sustained-release anti-microbial activity, the product consisting essentially of a polymeric material selected from the group consisting of fibers, fabrics, sheets, films and other stable woven, non-woven and knitted materials prepared from natural, man-made and synthetic polymers and an amine salt anti-microbial agent, the anti-microbial agent being incorporated in the polymeric material without an intermediary adhesive, carrier or linking agent and being releasable therefrom in anti-microbially effective amounts for a period of at least three days upon the product being brought into contact with a moist surface.
Type:
Grant
Filed:
June 5, 1995
Date of Patent:
January 13, 1998
Assignees:
Sion Texo Medic Ltd., Yissum Research Development Co. of Hebrew Univ. of Jerusalem, Israel Fiber Institute
Inventors:
David Levy, Hilda Guttmann, Itzhak Kahane
Abstract: A colonic delivery system for delivering a drug to the colon is provided. The system comprises a drug in combination with a matrix, wherein the matrix comprises a saccharide-containing polymer. According to the invention, the matrix is resistant to chemical and enzymatic degradation in the stomach and small intestine. The matrix is degraded in the colon by bacterial enzymatic action, and the drug is released. The system is useful for targeting drugs to the colon in order to treat colonic disease. The system is also useful for enteric administration of drugs such as proteins and peptides which are otherwise degraded in the stomach and small intestine.
Type:
Grant
Filed:
February 10, 1994
Date of Patent:
June 11, 1996
Assignees:
Perio Products, Ltd., Yissum Research Development Co. of the Hebrew Univ. of Jerusalem