Abstract: A method of killing a cell having a mutation in an Adenomatous polyposis coli (APC) gene is disclosed. The method comprises contacting the cell with an inhibitor of Casein kinase I (CKI), the CKI being selected from the group consisting of CKI-alpha and CKI-delta and CKI-epsilon, thereby killing the cell. The method may be used for treating cancers. Pharmaceutical compositions for treatment of cancers are also disclosed.
Type:
Application
Filed:
May 26, 2009
Publication date:
March 31, 2011
Applicant:
Yissum Research Development Company of the Hebrew Univeristy of Jerusalem Ltd
Inventors:
Yinon Ben-Neriah, Ela Elyada, Ariel Pribluda
Abstract: The development and use of hybrid metal-semiconductor nanoparticles for photocatalysis of a variety of chemical reactions such as redox reactions and water-splitting, is provided.
Type:
Application
Filed:
February 20, 2008
Publication date:
February 25, 2010
Applicant:
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERISTY OF JERUSALEM
Abstract: The present invention concerns the use of a sphingoid-polyalkylamine conjugate comprising a sphingoid backbone carrying, via a carbamoyl bond, at least one polyalkylamine chains as a capturing agent of nucleic acid molecules. The present invention also provides the use of the sphingoid polyalkylamine conjugate for the preparation of a pharmaceutical composition for the delivery of a nucleic acid molecule into a target cell. In a further aspect the invention provides a method for transfecting a nucleic acid into a target cell, the method comprises contacting said target cell with the sphingoid-polyalkylamine conjugate associated with a nucleic acid molecule, thereby transfecting said target cell with said nucleic acid molecule. Other aspects of the invention concern pharmaceutical compositions comprising said conjugate, therapeutic methods as well as kits, making use of the said conjugate. A preferred conjugate according to the invention is N-palmitoyl D-erythrosphingosyl-1-carbamoyl spermine.
Type:
Application
Filed:
June 17, 2004
Publication date:
November 9, 2006
Applicant:
Yissum Research Development Company of the Hebrew Univeristy of Jerusalem
Abstract: The present invention provides a new method for the production of inorganic semiconductor nanocrystals having a rod-like shape. More specifically the present invention provides a method of synthesizing rod shaped Group III-V semiconductor nanocrystals. The method comprises: reacting, in a high-boiling point organic solvent, a two-source precursor solution comprising at least one metal source and at least one nonmetal source, or a single-source precursor solution, with a metal catalyst or an agent capable of producing said metal catalyst, said high-boiling point organic solvent having a temperature above 200° C., thereby forming a reaction product comprising semiconductor nanocrystals of various shape; cooling the reaction product, and subsequently exposing said cooled reaction product to at least one centrifugal step so as to obtain semiconductor nanocrystals having substantially rod-like shape.
Type:
Grant
Filed:
May 15, 2002
Date of Patent:
September 7, 2004
Assignee:
Yissum Research Development Company of the Hebrew Univeristy
of Jerusalem
Abstract: An electrochemical electrode, comprising carbon particles distributed in porous, inorganic ceramic material produced by sol-gel technology, wherein the particles form a continuous network which enables conductivity throughout the sol-gel derived matrices.
Type:
Grant
Filed:
June 24, 1993
Date of Patent:
April 4, 1995
Assignee:
Yissum Research Development Company of the Hebrew Univeristy of Jerusalem
Inventors:
Ovadia Lev, Michael Tsionsky, Genia Gun, Victor Glezer