Patents Assigned to Yissum Research Development of the Hebrew University of Jerusalem
  • Patent number: 9435732
    Abstract: A hyperspectral method for detecting the present condition of an avian egg is disclosed in which a neural network algorithm is used to compare the spectrum of a test egg against a spectral library. The method can detect fertility with greater than 90% reliability on the day of laying and the gender of the chick with greater than 75% reliability on the 12th day after laying.
    Type: Grant
    Filed: June 27, 2010
    Date of Patent: September 6, 2016
    Assignees: Yissum Research Development of the Hebrew University of Jerusalem Ltd., Ramot at Tel Aviv University Ltd.
    Inventors: Israel Rozenboim, Eyal Ben Dor
  • Patent number: 8535672
    Abstract: Disclosed are methods and compositions for the inhibition of modulation of T cell costimulatory pathway by a pathogenic agent, particularly, the inhibition of activation of a T cell costimulatory pathway, preferably, the CD28/B7 pathway, by a pyrogenic exotoxin. The method of the invention is based on the inhibition of the direct interaction of a superantigen with a specific site within the dimer interface of a CD28 family member, using immunomodulatory peptides. Further disclosed are specific antagonist immunomodulatory peptides comprising an amino acid sequence derived from a dimer interface of a T cell co-stimulatory pathway member, or peptides which comprise an amino acid sequence which specifically binds to an amino acid sequence within the dimer interface of a T cell co-stimulatory pathway member. Compositions comprising said peptides and methods for the treatment of immune-related disorders are also disclosed.
    Type: Grant
    Filed: October 4, 2004
    Date of Patent: September 17, 2013
    Assignee: Yissum Research Development of the Hebrew University of Jerusalem
    Inventors: Raymond Kaempfer, Gila Arad
  • Publication number: 20120004106
    Abstract: The present invention discloses a method of inhibiting an ethylene response in a plant, comprising step of applying to at least one portion of the plant an effective ethylene response-inhibiting amount of a H1-cyclopropene-1-propanoic acid salt (CPAS). A method of prolonging the life of a cut flower, comprising applying to the cut flower an effective life-prolonging amount of CPAS and a method for the production a CPAS, comprising steps of (i) preparing 4-bromo-4-pentenoic acid or derivatives thereof; (ii) producing 1-cyclopropene-1-propanoic acid; and (iii), converting this acid into its water soluble salt, especially its sodium salt are presented. Additionally, a new family of water soluble CPAS inhibitors for ethylene response in a plant is disclosed.
    Type: Application
    Filed: July 17, 2008
    Publication date: January 5, 2012
    Applicant: YISSUM RESEARCH DEVELOPMENT OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD.
    Inventors: Raffi Goren, Akiva Apelbaum, Eliezer Goldschmidt, Moshe Huberman, Joseph Riov, Edward C. Sisler
  • Publication number: 20100255003
    Abstract: An article of manufacture comprising packaging material and a pharmaceutical composition is disclosed, the article of manufacture being identified in print in or on the packaging material for treatment of an immunity-related disease in a subject in need thereof. The pharmaceutical composition comprises a pharmaceutically acceptable carrier and, as an active ingredient, a compound being capable of modulating an interaction between a heparin-binding domain of a thrombospondin and a receptor of the heparin-binding domain.
    Type: Application
    Filed: June 20, 2006
    Publication date: October 7, 2010
    Applicants: Hadasit Medical Research Services and Development, Yissum Research Development of the Hebrew University of Jerusalem
    Inventors: Dror Mevorach, Alon Krispin, Yaniv Bledi, Michal Linial