Patents Assigned to Yonsung Fine Chemical Co.
  • CRYSTALLINE SALT OF ERIBULIN
    Publication number: 20230234961
    Abstract: An eribulin salt formed by combining an eribulin free base with a low molecular weight amine compound through a diacid compound is disclosed. As the diacid compound, edisylic acid, 1,5-naphthalenedisulfonic acid, trans-2-butene-1,4-dicarboxylic acid, pyrophosphoric acid, and combination thereof may be employed. As the amine, ammonia, cyclohexylamine, dicyclohexylamine, and a combination thereof may be employed. The eribulin salt can be crystallized by recrystallization to produce a crystalline eribulin salt with increased purity.
    Type: Application
    Filed: May 6, 2021
    Publication date: July 27, 2023
    Applicant: YONSUNG FINE CHEMICAL CO., LTD.
    Inventors: Areum BAEK, Hyunik SHIN, Yongseo PARK, Seongtaek KIM, Seunghui SIN
  • METHOD FOR PRODUCING MAXACALCITOL, AND INTERMEDIATE THEREFOR
    Publication number: 20230065886
    Abstract: A new and improved method for preparing maxacalcitol and an intermediate therefor is provided. The method is an efficient and cost-effective process for preparing maxacalcitol and an intermediate therefor.
    Type: Application
    Filed: November 26, 2020
    Publication date: March 2, 2023
    Applicant: YONSUNG FINE CHEMICAL CO., LTD.
    Inventors: Seung Woo KIM, Se Gyo JUNG, In A JUNG, Hyunik SHIN
  • METHOD FOR PREPARING LIFITEGRAST
    Publication number: 20230027871
    Abstract: An improved method for preparing lifitegrast is provided. The method is efficient and cost-effective and produces lifitegrast with high purity.
    Type: Application
    Filed: November 20, 2020
    Publication date: January 26, 2023
    Applicant: YONSUNG FINE CHEMICAL CO., LTE,
    Inventors: Hyun Ik SHIN, Eun Im JEONG, Chang Heon SUHL
  • METHOD FOR PREPARING NALDEMEDINE
    Publication number: 20220194953
    Abstract: Provided is a cost-effective process for preparing naldemedine having high purity with high yields.
    Type: Application
    Filed: April 14, 2020
    Publication date: June 23, 2022
    Applicant: YONSUNG FINE CHEMICAL CO., LTD.
    Inventors: Hyunik SHIN, Hyoseon LEE
  • Intermediate for preparing eribulin mesylate and process for preparing the same
    Patent number: 11142509
    Abstract: The present invention relates to a process for preparing a compound of formula (6) which is an intermediate for the preparation of eribulin mesylate with high yields and high purity, and an intermediate therefor.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: October 12, 2021
    Assignee: YONSUNG FINE CHEMICAL CO., LTD.
    Inventors: Hyunik Shin, Keeyoung Lee, Changyoung Oh
  • Method for preparing latanoprostene bunod, and intermediate therefor
    Patent number: 10870621
    Abstract: The present invention relates to a process for preparing latanoprostene bunod and an intermediate therefor. In accordance with the preparation process of the present invention, latanoprostene bunod can be efficiently and cost-effectively prepared while reducing side reactions.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: December 22, 2020
    Assignee: YONSUNG FINE CHEMICAL CO., LTD.
    Inventors: Eun Jeong Ko, Hyun Ik Shin, Kee Young Lee, Chang Young Oh
  • Intermediate for preparing eribulin mesylate and process for preparing the same
    Patent number: 10865212
    Abstract: The present invention relates to a process for preparing an intermediate for the preparation of eribulin mesylate with high yields, and an intermediate therefor.
    Type: Grant
    Filed: January 2, 2018
    Date of Patent: December 15, 2020
    Assignee: YONSUNG FINE CHEMICAL CO.. LTD.
    Inventors: Hyoseon Lee, Hyunik Shin, Keeyoung Lee, Changyoung Oh
  • INTERMEDIATE FOR PREPARING ERIBULIN MESYLATE AND PROCESS FOR PREPARING THE SAME
    Publication number: 20200361890
    Abstract: The present invention relates to a process for preparing a compound of formula (6) which is an intermediate for the preparation of eribulin mesylate with high yields and high purity, and an intermediate therefor.
    Type: Application
    Filed: November 8, 2018
    Publication date: November 19, 2020
    Applicant: YONSUNG FINE CHEMICAL CO., LTD.
    Inventors: Hyunik SHIN, Keeyoung LEE, Changyoung OH
  • Method for preparing treprostinil and intermediate therefor
    Patent number: 10800737
    Abstract: The present invention relates to a cost-effective and efficient method for preparing treprostinil with high purity, and an intermediate therefor.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: October 13, 2020
    Assignee: YONSUNG FINE CHEMICAL CO., LTD.
    Inventors: Hyun Ik Shin, Hyoseon Lee, Kyung Jin Lee, Kee Young Lee, Changyoung Oh
  • METHOD FOR PREPARING LATANOPROSTENE BUNOD, AND INTERMEDIATE THEREFOR
    Publication number: 20200165199
    Abstract: The present invention relates to a process for preparing latanoprostene bunod and an intermediate therefor. In accordance with the preparation process of the present invention, latanoprostene bunod can be efficiently and cost-effectively prepared while reducing side reactions.
    Type: Application
    Filed: August 3, 2018
    Publication date: May 28, 2020
    Applicant: YONSUNG FINE CHEMICAL CO., LTD.
    Inventors: Eun Jeong KO, Hyun Ik SHIN, Kee Young LEE, Chang Young OH
  • OPHTHALMIC COMPOSITION FOR GLAUCOMA TREATMENT
    Publication number: 20200129468
    Abstract: An eye drop composition for treating glaucoma is disclosed. The eye drop composition includes a prostaglandin analogue, a thickening agent, and a solubilizing agent, wherein the thickening agent is carboxymethylcellulose or a salt thereof, and the solubilizing agent is tyloxapol.
    Type: Application
    Filed: June 21, 2018
    Publication date: April 30, 2020
    Applicant: YONSUNG FINE CHEMICAL CO., LTD.
    Inventors: Areum BAEK, Youngsik CHUNG, Hyun Ik SHIN, Chang Young OH, Kee Young LEE
  • Method for preparing 3-((2S, 5S)-4-methylene-5-(3-oxopropyl)tetrahydrofurane-2-yl) propanol derivative, and intermediate therefor
    Patent number: 10538539
    Abstract: A method for preparing a 3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivative by a simple process with high yields, and an intermediate useful for the method.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: January 21, 2020
    Assignee: YONSUNG FINE CHEMICAL CO., LTD.
    Inventors: Hyun Ik Shin, Kee Young Lee, Changyoung Oh
  • INTERMEDIATE FOR PREPARING ERIBULIN MESYLATE AND PROCESS FOR PREPARING THE SAME
    Publication number: 20190337964
    Abstract: The present invention relates to a process for preparing an intermediate for the preparation of eribulin mesylate with high yields, and an intermediate therefor.
    Type: Application
    Filed: January 2, 2018
    Publication date: November 7, 2019
    Applicant: YONSUNG FINE CHEMICAL CO., LTD.
    Inventors: Hyoseon LEE, Hyunik SHIN, Keeyoung LEE, Changyoung OH
  • METHOD FOR PREPARING TREPROSTINIL AND INTERMEDIATE THEREFOR
    Publication number: 20190119205
    Abstract: The present invention relates to a cost-effective and efficient method for preparing treprostinil with high purity, and an intermediate therefor.
    Type: Application
    Filed: April 18, 2017
    Publication date: April 25, 2019
    Applicant: YONSUNG FINE CHEMICAL CO., LTD.
    Inventors: Hyun Ik SHIN, Hyoseon LEE, Kyung Jin LEE, Kee Young LEE, Changyoung OH
  • METHOD FOR PREPARING 3-((2S, 5S)-4-METHYLENE-5-(3-OXOPROPYL)TETRAHYDROFURANE-2-YL) PROPANOL DERIVATIVE, AND INTERMEDIATE THEREFOR
    Publication number: 20190023727
    Abstract: A method for preparing a 3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivative by a simple process with high yields, and an intermediate useful for the method.
    Type: Application
    Filed: January 13, 2017
    Publication date: January 24, 2019
    Applicant: YONSUNG FINE CHEMICAL CO., LTD.
    Inventors: Hyun Ik SHIN, Kee Young LEE, Changyoung OH
  • Process for preparing prostaglandin derivatives
    Patent number: 9126898
    Abstract: The present invention relates to a process for preparing a prostaglandin derivative and an intermediate therefor. In accordance with the present invention, the prostaglandin F (PGF) derivative can be efficiently prepared with high purity by removing the protecting group of a protected prostaglandin E (PGE) derivative obtained from conjugate addition and then stereoselectively reducing the ketone group on the cyclopentanone ring of the PGE derivative.
    Type: Grant
    Filed: March 11, 2010
    Date of Patent: September 8, 2015
    Assignee: YONSUNG FINE CHEMICAL CO., LTD.
    Inventors: Changyoung Oh, Kee Young Lee, Yong Hyun Kim, Jae Eun Joo
  • PROCESS FOR PREPARING PROSTAGLANDIN DERIVATIVES
    Publication number: 20130253218
    Abstract: The present invention relates to a process for preparing a prostaglandin derivative and an intermediate therefor. In accordance with the present invention, the prostaglandin F (PGF) derivative can be efficiently prepared with high purity by removing the protecting group of a protected prostaglandin E (PGE) derivative obtained from conjugate addition and then stereoselectively reducing the ketone group on the cyclopentanone ring of the PGE derivative.
    Type: Application
    Filed: May 23, 2013
    Publication date: September 26, 2013
    Applicant: YONSUNG FINE CHEMICAL CO., LTD.
    Inventors: Changyoung OH, Kee Young LEE, Yong Hyun KIM, Jae Eun JOO
  • PROCESS FOR PREPARING PROSTAGLANDIN DERIVATIVES
    Publication number: 20120108839
    Abstract: The present invention relates to a process for preparing a prostaglandin derivative and an intermediate therefor. In accordance with the present invention, the prostaglandin F (PGF) derivative can be efficiently prepared with high purity by removing the protecting group of a protected prostaglandin E (PGE) derivative obtained from conjugate addition and then stereoselectively reducing the ketone group on the cyclopentanone ring of the PGE derivative.
    Type: Application
    Filed: March 11, 2010
    Publication date: May 3, 2012
    Applicant: YONSUNG FINE CHEMICAL CO., LTD.
    Inventors: Changyoung Oh, Kee Young Lee, Yong Hyun Kim, Jae Eun Joo
  • Process for preparing prostaglandin derivatives and starting materials for the same
    Patent number: 7345181
    Abstract: The present invention provides a process for preparing benzoprostacycline derivatives of formula (1), i.e. 5,6,7-trinor-4,8-inter-m-phenylene PGI2 derivatives, and vinyl tin compounds of formula (III) as starting materials for the same.
    Type: Grant
    Filed: September 18, 2003
    Date of Patent: March 18, 2008
    Assignee: Yonsung Fine Chemical Co., Ltd.
    Inventors: Yong-Hyun Kim, Yiu-Suk Lee
  • Process for preparing prostaglandin derivatives and stereospecific starting material thereof
    Patent number: 6989458
    Abstract: The present invention relates to a process for effectively preparing prostaglanin derivatives and to a stereospecific alkyl halide containing 15S-alcohol group as a starting material.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: January 24, 2006
    Assignee: Yonsung Fine Chemical Co.
    Inventors: Won-Hun Ham, Chang-Young Oh, Yong-Hyun Kim, Yiu-Suk Lee, Kee-Young Lee