Abstract: A door frame structure of a vehicle, of which a door frame is covered with a frame molding. The door frame has a flat peripheral wall extending around a window opening of a vehicle door and a protrusion protruding from an inside end of the flat peripheral wall. The frame molding is composed of a synthetic resin or TPO and is attached to an outside end of the peripheral wall of the door frame. A pair of shelf projections are integrally formed on an inside surface of the frame molding from about a widthwise center thereof so as to be spaced from each other. By press-inserting the flat peripheral wall of the door frame between the shelf projections of the frame molding, the frame molding is secured to the door frame.