Abstract: The present invention relates to a pharmaceutical composition for the treatment of hepatitis C which comprises a mixed extract, particularly a mixed aqueous extract or a mixed alcohol extract, of Phellodendron amurense RUPRECHT cortex and Patrinia scabiosaefolia FISCH. as an active ingredient. The mixed extract according to the present invention exhibits an anti-viral activity for hepatitis C and help prevents hepatic cirrhosis orginated from hepatitis C, and further treats hepatitis and hepatic cirrhosis by potentiating the immunological function to inhibit the proliferation of hepatitis C virus and stimulating the proliferation of T helper cells to increase the host immune system. Furthermore, the mixed extract of the present invention is a mixed extract of natural plants characterized in that it does not exhibit any side effects nor drug resistance, and its activity is maintained even when used for a long period.