Patents Assigned to YOUNGENE THERAPEUTICS CO., LTD
  • Amine solvate of sodium-glucose linked transporter inhibitor, and preparation method and application thereof
    Patent number: 10519183
    Abstract: Disclosed are an amine solvate of a sodium-glucose linked transporter (SGLT) inhibitor, and a preparation method and application thereof. The SGLT inhibitor is (1S,2S,3S,4R,5S)-5-(3-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-4-ethylbenzyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol. Further provided is a crystalline compound of the amine solvate, a pharmaceutical composition comprising the amine solvate, and an application of the amine solvate in preparing an SGLT-inhibiting pharmaceutical product.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: December 31, 2019
    Assignee: Youngene Therapeutics Co., Ltd.
    Inventors: Lei Zhang, Yuan Wang
  • AMINE SOLVATE OF SODIUM-GLUCOSE LINKED TRANSPORTER INHIBITOR, AND PREPARATION METHOD AND APPLICATION THEREOF
    Publication number: 20190135848
    Abstract: Disclosed are an amine solvate of a sodium-glucose linked transporter (SGLT) inhibitor, and a preparation method and application thereof. The SGLT inhibitor is (1S,2S,3S,4R,5S)-5-(3-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-4-ethylbenzyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol. Further provided is a crystalline compound of the amine solvate, a pharmaceutical composition comprising the amine solvate, and an application of the amine solvate in preparing an SGLT-inhibiting pharmaceutical product.
    Type: Application
    Filed: March 27, 2017
    Publication date: May 9, 2019
    Applicant: Youngene Therapeutics Co., Ltd.
    Inventors: Lei Zhang, Yuan Wang
  • C-aryl glucoside derivative, preparation methods thereof, and medical applications thereof
    Patent number: 10011627
    Abstract: C-aryl glucoside derivatives, preparation methods thereof, and medical applications thereof are described. Specifically, compounds represented by formula I, and, tautomers, enantiomers, diastereomers, racemates, and pharmaceutically acceptable salts of the compounds, preparation methods thereof, pharmaceutical compositions containing the compounds, and applications thereof are described. Compounds of formula (I) are useful as therapeutic agents, and particularly as sodium-dependent glucose contransporter protein (SGLT) inhibitors.
    Type: Grant
    Filed: August 19, 2014
    Date of Patent: July 3, 2018
    Assignee: YOUNGENE THERAPEUTICS CO., LTD
    Inventors: Huijuan Zhong, Jianchun Liao, Hongping Yu, Yaochang Xu, Qing Li, Jianghua Chen, Peng Gao, Songliang Tan, Shaobao Wang