Patents Assigned to Yung Shin Pharmaceutical Ind. Co., Ltd.
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Patent number: 7754751Abstract: A method for preferentially inhibiting release of pro-inflammatory cytokines over release of anti-inflammatory cytokines using a fused pyrazolyl compound of formula (I): A is R or in which R is H, alkyl, aryl, cyclyl, heteroaryl, or heterocyclyl; each of Ar1, Ar2, and Ar3, independently, is phenyl, thienyl, furyl, or pyrrolyl; each of R1, R2, R3, R4, R5, and R6, independently, is R?, nitro, halogen, —C(O)—OR?, —C(O)—SR?, —C(O)—NR?R?, —(CH2)mOR?, —(CH2)mSR?, —(CH2)mNR?R?, —(CH2)mCN, —(CH2)mC(O)—OR?, —(CH2)mC(O)H, or R1 and R2 together, R3 and R4 together, or R5 and R6 together are —O(CH2)nO—, in which each of R? and R?, independently, is H, alkyl, cyclyl, aryl, heteroaryl, heterocyclyl; and m is 0, 1, 2, 3, 4, 5, or 6; and n is 1, 2, or 3. This invention also covers a method of inhibiting activity of NF-?B with such a compound.Type: GrantFiled: March 15, 2005Date of Patent: July 13, 2010Assignee: Yung Shin Pharmaceutical Ind. Co., Ltd.Inventors: Che-Ming Teng, Jih-Hwa Guh, Shiow-Lin Pan, Sheng-Chu Kuo, Fang-Yu Lee
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Patent number: 7645750Abstract: A method for treating or preventing symptoms of hormonal variation includes administering an effective amount of a receptor antagonist to a subject having one or more symptoms of hormonal variations, wherein the receptor antagonist binds to at least one selected from the group consisting of a serotonin type 2A (5-HT2A) and a dopamine type 2 (D2) receptors.Type: GrantFiled: December 13, 2006Date of Patent: January 12, 2010Assignee: Yung Shin Pharmaceutical Ind. Co., Ltd.Inventor: Hung-Ming Wu
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Patent number: 7378532Abstract: A fused pyrazolyl compound of the following formula: wherein A, Ar1, Ar2, R1, R2, R3, and R4, are as defined herein. Also disclosed is a pharmaceutical composition containing an effective amount of the above-described fused pyrazolyl compound.Type: GrantFiled: November 29, 2004Date of Patent: May 27, 2008Assignee: Yung Shin Pharmaceutical Ind. Co., Ltd.Inventors: Sheng-Chu Kuo, Fang-Yu Lee, Che-Ming Teng, Li-Jiau Huang, Li-Chen Chou, Jih-Hwa Guh, Shiow-Lin Pan
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Publication number: 20070149554Abstract: A method for treating cancer, which includes administrating to a subject in need thereof an effective amount of a chemotherapeutic agent and an effective amount of a compound of the formula: in which, A is H or each of Ar1, Ar2, and Ar3, independently, is phenyl, thienyl, furyl, pyrrolyl, pyridinyl, or pyrimidinyl; each of R1, R2, R3, R4, R5, and R6, independently, is R, nitro, halogen, C(O)OR, C(O)SR, C(O)NRR?, (CH2)mOR, (CH2)mSR, (CH2)mNRR?, (CH2)mCN, (CH2)mC(O)OR, (CH2)mCHO, (CH2)mCH?NOR, (CH2)mC(O)N(OR)R?, N(OR)R?, or R1 and R2 together, R3 and R4 together, or R5 and R6 together are O(CH2)mO, in which each of R and R?, independently, is H or C1˜C6 alkyl; and m is 0, 1, 2, 3, 4, 5, or 6, and n is 0, 1, 2, or 3.Type: ApplicationFiled: December 21, 2006Publication date: June 28, 2007Applicant: Yung Shin Pharmaceutical Ind. Co., Ltd.Inventors: Sheng-Chu Kuo, Che-Ming Teng, Fang-Yu Lee, Shiow-Lin Pan, Jih-Hwa Guh
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Publication number: 20070142449Abstract: A method for treating an angiogenesis-related disorder or cancer. The method includes administrating to a subject in need thereof an effective amount of a compound of the formula: Each of Ar1, Ar2, and Ar3, independently, is phenyl, thienyl, furyl, pyrrolyl, pyridinyl, or pyrimidinyl; each of R1, R2, R3, R4, R5, and R6, independently, is R, nitro, halogen, C(O)OR, C(O)SR, C(O)NRR?, (CH2)mOR, (CH2)mSR, (CH2)mNRR?, (CH2)mCN, (CH2)mC)O)OR, (CH2)mCHO, (CH2)mCH?NOR, or R1 and R2 together, R3 and R4 together, or R5 and R6 together are O(CH2)mO, in which each of R and R?, independently, is H or C1˜C6 alkyl; and m is 0, 1, 2, 3, 4, 5, or 6, and n is 0, 1, 2, or 3.Type: ApplicationFiled: January 3, 2007Publication date: June 21, 2007Applicant: Yung Shin Pharmaceutical Ind. Co., Ltd.Inventors: Che-Ming Teng, Sheng-Chu Kuo, Fang-Yu Lee, Shiow-Lin Pan, Jih-Hwa Guh
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Patent number: 7202062Abstract: The present invention provides two new microorganism strains of Saccharothrix, designated as YS-44442 and YS-45494, a process of producing pravastatin using the strains, and an improved process for isolation of (HMG)-CoA reductase inhibitors.Type: GrantFiled: December 3, 2003Date of Patent: April 10, 2007Assignee: Yung Shin Pharmaceutical Ind. Co., Ltd.Inventors: Fang-Yu Lee, Ming-Liang Lee, Anderson C. Hong, Schung-Ching Chiu
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Patent number: 7160916Abstract: This invention features a method for enhancing bone growth or inhibiting bone resportion. The method includes administering to a subject in need thereof a compound of the following formula: A is H, R, or each of Ar1, Ar2, and Ar3, independently, is phenyl, thienyl, furyl, or pyrrolyl; each of R1, R2, R3, R4, R5, and R6, independently, is H, halogen, R, C(O)OH, C(O)OR, C(O)SH, C(O)SR, C(O)NH2, C(O)NHR, C(O)NRR?, ROH, ROR?, RSH, RSR?, NHR, NRR?, RNHR?, or RNR?R?; or R1 and R2 together, R3 and R4 together, or R5 and R6 together are ORO; wherein each of R, R?, and R?, independently is C1˜C6 alkyl; and n is 1, 2, or 3.Type: GrantFiled: September 1, 2004Date of Patent: January 9, 2007Assignee: Yung Shin Pharmaceutical Ind. Co., Ltd.Inventors: Wen-Mei Fu, Chih-Hsin Tang, Rong-Sen Yang, Che-Ming Teng, Sheng-Chu Kuo, Fang-Yu Lee
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Patent number: 7094403Abstract: The invention relates to Mycobacterium tuberculosis superoxide dismutase antibodies, methods of using them for detection of M. tuberculosis, methods of testing for an inhibitor of an M. tuberculosis superoxide dismutase, and methods of detecting tuberculosis infection.Type: GrantFiled: January 17, 2003Date of Patent: August 22, 2006Assignee: Yung Shin Pharmaceutical Ind. Co., Ltd.Inventors: Fang-Jen S. Lee, Chung-Hsiun H. Wu
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Patent number: 6943186Abstract: The present invention features a method for treating sepsis. The method includes administrating to a subject in need thereof an effective amount of a fused pyrazolyl compound of formula (I): A is H, C1˜C6 alkyl, or in which n is 0, 1, 2, or 3; each of Ar1, Ar2, and Ar3, independently, is phenyl, pyridinyl, thienyl, furyl, or pyrrolyl; and each of R1, R2, R3, R4, R5, and R6, independently, is XYZ; or R1 and R2 together, R3 and R4 together, or R5 and R6 together are O(CH2)1-6O; in which X is a bond or C1˜C6 alkylene, Y is a bond, O, S, OC(O), OC(O)(CH2)1-6C(O)O, C(O)O, C(O)S, C(O)NH, C(O)NC1˜C6 alkyl, NH, or NC1˜C6 alkyl, and Z is H, halogen, CN, NO2, or C1˜C6 alkyl; and provided that one of R3 and R4 is not H.Type: GrantFiled: January 24, 2003Date of Patent: September 13, 2005Assignee: Yung Shin Pharmaceutical Ind. Co., Ltd.Inventors: Che-Ming Teng, Shiow-Lin Pan, Jih-Hwa Guh, Sheng-Chu Kuo, Fang-Yu Lee
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Patent number: 6887997Abstract: Fused tri-heterocyclic compounds of formula: R1 is H or alkyl; R2 is H, alkyl, alkenyl, aryl, heteroaryl, cyclyl, or heterocyclyl; R3 and R4, independently, is H, alkyl, alkenyl, aryl, heteroaryl, cyclyl, heterocyclyl, or (CRaRb)mX(CRcRd)nY; in which X is a bond, O, S, or NRe; Y is alkoxy, aryloxy, heteroaryloxy, OC(O)Re, C(O)Re, N(ReRe?), NReC(O)Re?, S(O)2Re, or SRe; each of m and n, independently, is 1, 2, 3, 4, or 5; each of Ra, Rb, Rc, Rd, Re, and Re?, independently, is H, alkyl, aryl, heteroaryl, cyclyl, or heterocyclyl; and R5 is H or halogen.Type: GrantFiled: May 31, 2002Date of Patent: May 3, 2005Assignee: Yung Shin Pharmaceutical Ind. Co., Ltd.Inventors: Fang Yu Lee, Fang Chen Lee, Chang An Yang, Ma Wei Yong, Xu Ai Wu, Wu Qiu Ye, Xiao Xu Hua
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Patent number: 6716615Abstract: The present invention provides two new microorganism strains of Saccharothrix, designated as YS-44442 and YS-45494, a process of producing pravastatin using the strains, and an improved process for isolation of (HMG)-CoA reductase inhibitors.Type: GrantFiled: February 27, 2002Date of Patent: April 6, 2004Assignee: Yung Shin Pharmaceutical Ind. Co., Ltd.Inventors: Fang-Yu Lee, Ming-Liang Lee, Anderson C. Hong
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Publication number: 20030219443Abstract: The invention relates to Mycobacterium tuberculosis superoxide dismutase antibodies, methods of using them for detection of M. tuberculosis, methods of testing for an inhibitor of an M. tuberculosis superoxide dismutase, and methods of detecting tuberculosis infection.Type: ApplicationFiled: January 17, 2003Publication date: November 27, 2003Applicant: Yung Shin Pharmaceutical Ind. Co., Ltd., a Taiwan corporationInventors: Fang-Jen S. Lee, Chung-Hsiun H. Wu
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Patent number: 6562614Abstract: The invention relates to a transgenic knockout yeast which has a disruption in the gene encoding for a yeast ADP-ribosylation factor-like protein.Type: GrantFiled: May 4, 2001Date of Patent: May 13, 2003Assignee: Yung Shin Pharmaceutical Ind. Co., Ltd.Inventors: Fang-Jen S. Lee, Chun-Fang Huang
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Patent number: 6517845Abstract: The invention relates to Mycobacterium tuberculosis superoxide dismutase antibodies, methods of using them for detection of M. tuberculosis, methods of testing for an inhibitor of an M. tuberculosis superoxide dismutase, and methods of detecting tuberculosis infection.Type: GrantFiled: November 12, 1999Date of Patent: February 11, 2003Assignee: Yung Shin Pharmaceutical Ind. Co., Ltd.Inventors: Fang-Jen S. Lee, Chung-Hsiun H. Wu
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Publication number: 20020081713Abstract: The invention relates to a transgenic knockout yeast which has a disruption in the gene encoding for a yeast ADP-ribosylation factor-like protein.Type: ApplicationFiled: May 4, 2001Publication date: June 27, 2002Applicant: Yung Shin Pharmaceutical Ind. Co., Ltd., Taiwan corporationInventors: Fang-Jen S. Lee, Chun-Fang Huang
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Patent number: 6399591Abstract: A blank tablet of this invention, typically, includes an absorbent, a disintegrant, a lubricant, and a diluent or a binder, or a mixture of a diluent and a binder. An active ingredient in liquid form is introduced into the blank tablet to produce a pharmaceutical composition.Type: GrantFiled: January 19, 2000Date of Patent: June 4, 2002Assignee: Yung-Shin Pharmaceutical Ind. Co., Ltd.Inventors: Fang-Yu Lee, Fang-Chen Lee
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Patent number: 6387942Abstract: A method of treating a disorder related to cell activation induced by protease-activated receptors. The method includes administering to a subject in need thereof a compound having a pyrazolyl core; an aryl group, via an via an alkylene linker, bonded to 1-N of the pyrazolyl core; a second aryl group fused at 4-C and 5-C of the pyrazolyl core; and a third aryl group bonded directly to 3-C of the pyrazolyl core.Type: GrantFiled: June 18, 2001Date of Patent: May 14, 2002Assignee: Yung Shin Pharmaceutical Ind. Co. LtdInventors: Che-Ming Teng, Sheng-Chu Kuo, Fang Yu Lee
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Patent number: 6002021Abstract: An acylation process using a sulfonic acid, a salt of the sulfonic acid, or a mixture thereof, as a catalyst. Compound 6 is prepared by protecting the 4-hydroxyl group on the pyranone ring of the 8'-hydroxy compound 2 to form a .beta.-protected compound 3, acylating the 8-hydroxy group on the polyhydronaphthyl ring of compound 3 to give protected ester, compound 4, then removing the protecting group, where the compounds 6, 2, 3 and 4 are as described in the specification.Type: GrantFiled: June 29, 1998Date of Patent: December 14, 1999Assignees: Industrial Technology Research Institute, Yung Shin Pharmaceutical Ind. Co Ltd.Inventors: Yuh-Lin Yang, Yeuk-Chuen Liu
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Patent number: 5994566Abstract: The process for preparing compound 2 by reacting the compound 1, each as described in the specification hereof, with a tetraalkyl ammonium hydroxide having the formula R.sub.1 R.sub.2 R.sub.3 R.sub.4 N.sup.+ OH.sup.-, wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently a C.sub.1 -C.sub.10 alkyl group or a (C.sub.6 -C.sub.10) aryl (C.sub.1 -C.sub.10) alkyl group, to obtain an triol carboxylate thereof, acidifying the triol carboxylate, then lactonizing the product to obtain diol lactone, a key intermediate for production of antihypercholesterolemia agents.Type: GrantFiled: June 29, 1998Date of Patent: November 30, 1999Assignees: Industrial Technology Research Institute, Yung Shin Pharmaceutical Ind. Co., Ltd.Inventors: Yuh-Lin Yang, Yeuk-Chuen Liu