Abstract: Disclosed herein are antibodies capable of inhibiting canine vascular endothelial growth factor and uses thereof in treating a canine angiogenesis-related disorder such as a proliferative disease.

Abstract: Disclosed herein are antibodies capable of inhibiting canine vascular endothelial growth factor and uses thereof in treating a canine angiogenesis-related disorder such as a proliferative disease.

Abstract: A pharmaceutical acceptable composition is provided. The composition comprises an effective amount of a non-steroidal anti-inflammatory drug (NSAID), a local anesthetic, and an antiviral drug.

Abstract: A pharmaceutical acceptable composition is provided. The composition comprises an effective amount of a non-steroidal anti-inflammatory drug (NSAID), a local anesthetic, and an antiviral drug.

Abstract: Disclosed in this invention is a method of treating a disorder associated with low cGMP levels. The method includes administering to a subject in need thereof an effective amount of a compound having a pyrazolyl core, a first aryl group bonded to 3-C of the pyrazolyl core, and a second aryl group fused at 4-C and 5-C of the pyrazolyl core. Also disclosed are pharmaceutical compositions containing these compounds.

Abstract: The present invention provides pharmaceutically acceptable salts having local anesthetic and anti-inflammatory activities. The preferred pharmaceutically acceptable salt is a diclofenac salt of lidocaine. Diclofenac is a non-steroidal anti-inflammatory drug (“NSAID”). Lidocaine is a local anesthetic. Other NSAID (except the salicylic acid derivatives of NSAID) can be used to replace diclofenac and/or other local anesthetics can be used to replace lidocaine. The pharmaceutically acceptable salts are crystalline compounds, which are distinctively different from either the NSAID alone or the local anesthetic alone, as indicated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), High Performance Liquid Chromatography (HPLC) and Fourier-Transformed Infrared Spectroscopy (FTIR) analyses.

Abstract: The present invention provides oral pharmaceutical compositions for acetic acid class of non-steroidal anti-inflammatory drug (NSAID), particularly ketorolac. The pharmaceutical composition contains a core, a drug layer (which comprises the drug, a binder, and a disintegrant), a protecting layer, and an enteric coating layer. The oral pharmaceutical compositons are particularly useful for treating patients with moderate to acute pain. The present invention also provides a method for making the pharmaceutical compositions and a method for using the pharmaceutical compositions.

Abstract: The present invention discloses a novel and improved pharmaceutical salt, nicotinate, of amlodipine having the following formula: The present invention also discloses methods for preparing and using the same.

Abstract: The present invention relates to an oral pharmaceutical preparation which contains an acid or base labile pharmaceutical ingredient which is embedded in an oily matrix which is controlled at neutral pH. The oily matrix-embedded pharmaceutical ingredient is encapsulated and then being coated by an enteric coating. The enteric coating enables the pharmaceutical ingredient to reach the small intestine for absorption. The oily matrix has the advantages of avoiding acidic or basic conditions. It can also isolate moisture and oxygen so as to allow for greater absorption and bioavailability of the pharmaceutical ingredient in vivo.

Abstract: The invention provides three orally administered ciprofloxacin formulations: The first formulation comprises 60-75 wt % of ciprofloxacin or at least one of pharmacologically acceptable salt; 0.3-10 wt % of pregelatinized starch as binder; 5-30 wt % of lactose as diluent; 1-10 wt % of sodium starch glycolate as disintegrant; and 0.5-2 wt % of magnesium stearate as lubricant. The second formulation comprises 60-75 wt % of ciprofloxacin or its pharmacologically acceptable salt; 1-5 wt % of polyvinyl pyrrolidone as binder; 5-30 wt % of lactose as diluent; 1-10 wt % of sodium starch glycolate as disintegrant; and 0.5-2 wt % of magnesium stearate as lubricant. The third formulation comprises 60-75 wt % of ciprofloxacin or at least one of pharmacologically acceptable salt; 1-8 wt % of polyvinyl alcohol as binder; 5-30 wt % of lactose as diluent; 1-10 wt % of sodium starch glycolate as disintegrant; and 0.5-2 wt % of magnesium stearate as lubricant.