Patents Assigned to YUNNAN INSTITUTE OF MATERIA MEDICA
  • Polymorph of triaryldimethylpiperazine dihydrochloride and preparation method and application thereof
    Patent number: 10730851
    Abstract: The application discloses five polymorph forms B, P, F, J, O of (4-((R)-((2S,5R)-4-(3-fluorobenzyl)-(2,5-dimethylpiperazine-1-yl)(3-hydroxyphenyl)methyl)phenyl)(4-methylpiperidine-1-yl)methanone dihydrochloride, preparation methods thereof and application thereof in the manufacture of a medicament for preventing or treating a mood disorder or a disease related to a ? opioid receptor.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: August 4, 2020
    Assignee: Yunnan Institute of Materia Medica
    Inventors: Jingkun Wang, Zhaoyun Zhu, He Song, Min Sun, Tao Cui, Zeren Wang, Zhi Yang, Min Su, Hongbin Liu, Bing Shi, Yong Mao, Huilang Liu, Zeqian Li, Chunmei Zhao, Mei Su, Fang Yuan, Tiancai Zhang, Yong Liu, Kuanren Zhang, Yunlin Wei, Yuehai Shen
  • POLYMORPH OF TRIARYLDIMETHYLPIPERAZINE DIHYDROCHLORIDE AND PREPARATION METHOD AND APPLICATION THEREOF
    Publication number: 20190270720
    Abstract: The application discloses five polymorph forms B, P, F, J, O of (4-((R)-((2S,5R)-4-(3-fluorobenzyl)-(2,5-dimethylpiperazine-1-yl)(3-hydroxyphenyl)methyl)phenyl)(4-methylpiperidine-1-yl)methanone dihydrochloride, preparation methods thereof and application thereof in the manufacture of a medicament for preventing or treating a mood disorder or a disease related to a ? opioid receptor.
    Type: Application
    Filed: November 21, 2016
    Publication date: September 5, 2019
    Applicant: Yunnan Institute of Materia Medica
    Inventors: Jingkun Wang, Zhaoyun Zhu, He Song, Min Sun, Tao Cui, Zeren Wang, Zhi Yang, Min Su, Hongbin Liu, Bing Shi, Yong Mao, Huilang Liu, Zeqian Li, Chunmei Zhao, Mei Su, Fang Yuan, Tiancai Zhang, Yong Liu, Kuanren Zhang, Yunlin Wei, Yuehai Shen
  • Crystal forms of scutellarin aglycone and preparation thereof
    Patent number: 10172824
    Abstract: The invention belongs to the field of medicine and chemical industry, and particularly relates to multiple crystal forms of scutellarin aglycone and preparation thereof. The invention also relates to use of said crystal forms of scutellarin aglycone in the manufacture of a medicament for preventing and/or treating a cardiovascular or cerebrovascular disease, rheumatic arthritis or stroke sequelae, etc. The crystal forms of scutellarin aglycone according to the invention have good stability, and can solve the problems concerning poor oral absorption and low bioavailability of scutellarin.
    Type: Grant
    Filed: December 2, 2015
    Date of Patent: January 8, 2019
    Assignees: YUNNAN INSTITUTE OF MATERIA MEDICA, HLK PHARMACEUTICALS CO., LTD.
    Inventors: Zeren Wang, Jun Xu, Minghui Wang, Zhaoyun Zhu, Jingkun Wang, Shuangxi Mei, Wenqiang Sun, Tao Cui