Patents Assigned to Yunnan University
-
Patent number: 11464795Abstract: Provided are use of a saponin compound of formula (I) or (II), or a pharmaceutically acceptable salt, prodrug or solvate thereof, in the manufacture of a medicament targeting PD-1. The medicament targeting PD-1 is one which treats a disease by inhibiting PD-1 from binding to a ligand thereof. The disease may be a tumor, an infection caused by a bacterium, a virus or a fungus, or an inflammatory disease.Type: GrantFiled: July 12, 2018Date of Patent: October 11, 2022Assignees: East China University Of Science And Technology, Yunnan University, Shanghai Institute of Materia Medica, Chinese Academy of SciencesInventors: Honglin Li, Weilie Xiao, Lili Zhu, Lina Quan, Qiao Li, Yanyan Diao, Zhenjiang Zhao, Hualiang Jiang
-
Patent number: 11447470Abstract: Disclosed is a pyrimidinone-containing compound represented by formula I, a preparation method thereof, a pharmaceutical composition, and an application thereof. The pyrimidinone-containing compound of the present disclosure can be used as HIV-1 inhibitor and can be also used in the treatment of human immunodeficiency virus infection.Type: GrantFiled: March 4, 2019Date of Patent: September 20, 2022Assignees: Yunnan University, Kunming Institute of Zoology, Chinese Academy of SciencesInventors: Yanping He, Hongbin Zhang, Yongtang Zheng, Yumeng Wu, Chengrun Tang, Ruomei Rui, Liumeng Yang, Jiangyuan Wang
-
Patent number: 11420959Abstract: Disclosed is a DACOs-type NNRTIs amino acid ester derivative, a preparation method thereof, a pharmaceutical composition, and an application thereof. The structure of the DACOs-type NNRTIs amino acid ester derivative is represented by formula (I). The DACOs-type NNRTIs amino acid ester derivative represented by formula (I) can be used as HIV-1 inhibitors and for the preparation of a drug for treating and/or preventing immunodeficiency viruses.Type: GrantFiled: March 4, 2019Date of Patent: August 23, 2022Assignees: Yunnan University, Kunming Institute of Zoology, Chinese Academy of SciencesInventors: Yanping He, Hongbin Zhang, Yongtang Zheng, Yufang Zhang, Chengrun Tang, Wei Ding, Liumeng Yang, Yiming Li
-
Patent number: 11214567Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having an oxadiazole-oxadiazolone structure (e.g., oxadiazole-phenyl-oxadiazolone compounds, oxadiazole-pyridine-oxadiazolone compounds, oxadiazole-indole-oxadiazolone compounds, oxadiazole-quinoline-oxadiazolone compounds, oxadiazole-pyrrole-oxadiazolone compounds, and oxadiazole-vinyl-oxadiazolone compounds), and their use as therapeutics for the treatment of cancer and other diseases.Type: GrantFiled: August 23, 2018Date of Patent: January 4, 2022Assignees: The Regents of the University of Michigan, YUNNAN UNIVERSITYInventors: Nouri Neamati, Yi Jin, Jun Lin
-
Patent number: 11168096Abstract: This disclosure relates to pharmaceutical chemistry, and more particularly to a metalloporphyrin compound, and a preparation and application thereof. The metalloporphyrin compound is shown in formula (I), or an optical isomer, a pharmaceutically-acceptable salt or a solvate thereof, and can specifically recognize the HIV RNA and effectively inhibit HIV reverse transcriptase. This disclosure also provides uses of the compound in the preparation of a reagent for selectively recognizing HIV TAR RNA and a HIV reverse transcriptase inhibitor.Type: GrantFiled: December 26, 2020Date of Patent: November 9, 2021Assignee: YUNNAN UNIVERSITYInventors: Feng Gao, Xudan Bi, Yuechen Zhou, Rong Yang, Guokui Li, Yan Li
-
Patent number: 11165031Abstract: A layered metal oxide field effect material forms a heterojunction from metal oxides with different band gaps, and defines a band gap difference (?E)?1 eV. Band bending is generated at the interface of the heterojunction, such that a potential barrier is formed on the side with the larger band gap and a triangular potential well is formed on the side with the smaller band gap, and under the induction of a gate electric field, a polarized charge is generated at the interface of the heterojunction, and a large number of carriers are accumulated. Therefore, the present layered metal oxide field effect material has high carrier mobility higher than 103 cm2/V·s, and overcomes the problem that the carrier mobility of a conventional metal oxide field effect material is low, it is required to fabricate the metal oxide field effect material into a crystal phase structure with a relatively high cost, and even that a substrate thereof with a crystal phase structure is required.Type: GrantFiled: October 12, 2018Date of Patent: November 2, 2021Assignee: YUNNAN UNIVERSITYInventors: Zhenghong Lu, Tao Zhang, Dengke Wang
-
Patent number: 11155475Abstract: A skid mounted device for upper-spreading internal diffusion vertical plug flow photocatalytic wastewater treatment includes internal diffusion vertical plug flow photocatalytic reaction tank groups and a skid base. The internal diffusion vertical plug flow photocatalytic reaction tank groups are arranged on the skid base. The internal diffusion vertical plug flow photocatalytic reaction tank groups are connected to each other in series, in parallel, or in series-parallel. Each internal diffusion vertical plug flow photocatalytic reaction tank group consists of two or more photocatalytic reaction tanks connected in series, in parallel, or in series-parallel. The wastewater pipes connected to the photocatalytic reaction tanks in each internal diffusion vertical plug flow photocatalytic reaction tank group are mounted above the photocatalytic reaction tanks.Type: GrantFiled: May 5, 2018Date of Patent: October 26, 2021Assignee: YUNNAN UNIVERSITYInventors: Jiaqiang Wang, Wei Wang, Yizhou Li, Liang Jiang
-
Publication number: 20200264345Abstract: The present invention provides a platform and a method for rapidly and precisely measuring concentration-dependent diffusion coefficients of binary solution. The key element of the platform is an asymmetric liquid-core cylindrical lens, which acts as both diffusion cell and imaging device to take diffusion image, concentration spatial and temporal profile of diffusion solution, Ce(z, t), can be deduced from the diffusion image. Assuming concentration-dependent diffusion coefficient to be a polynomial D(C)=D0(1+?1C+?2C2+?3C3+ . . . ), where D0, ?1, ?2 and ?3 are under-determined parameters, the finite difference method is applied to solve numerically Fick diffusion equation, the calculated concentration profiles (Cn(z, t)s) by varying the under-determined parameters are compared with the Ce(z, t), the parameters corresponding minimum concentration standard deviation are selected to determine D(C).Type: ApplicationFiled: October 21, 2019Publication date: August 20, 2020Applicant: Yunnan UniversityInventors: Xiaoyun Pu, Li Wei, Weidong Meng
-
Patent number: 10669223Abstract: A method for synthesizing 4-(Hydroxymethyl)benzoic acid using P-xylene (PX) as a raw material, including: dissolving PX in an organic solvent to undergo an oxidation reaction with an oxidizing agent under an action of an M-MOF catalyst; and after the oxidation reaction, performing a post-treatment to obtain the 4-(Hydroxymethyl)benzoic acid; wherein, the metal element M in the M-MOF catalyst is Fe, Cu, Cr, Mn, Cu/Fe, Cu/Cr, Cu/Mn, Fe/Mn, Cr/Fe or Cr/Mn. The by-product produced in the reaction process is little, the yield is high, and the separation is convenient. The acid-base neutralization is not required in the reaction process, reducing pollution. A one-step reaction is employed which has mild reaction conditions, short reaction time, low pollution and is convenient for industrialized mass production; and the obtained 4-(Hydroxymethyl)benzoic acid can be used for preparing medicines and liquid crystal materials having wide applications.Type: GrantFiled: May 5, 2018Date of Patent: June 2, 2020Assignee: YUNNAN UNIVERSITYInventors: Jiaqiang Wang, Ying Li, Daomei Chen
-
Patent number: 10653702Abstract: The invention relates to the field of metal-organic framework materials and the field of medical technology, relates to a method for inhibiting tumor angiogenesis or preventing and/or treating tumor, comprising administering to a subject in need thereof an effective amount of a metal-organic framework comprising Fe and ligand. The invention further relates to a method for inhibiting the expression of matrix metalloproteinase in a cell, comprising administering to the cell an effective amount of a metal-organic framework comprising Fe and ligand.Type: GrantFiled: May 8, 2017Date of Patent: May 19, 2020Assignee: Yunnan UniversityInventors: Bin Li, Daomei Chen, Jiaqiang Wang, Minfang Nie
-
Publication number: 20200131055Abstract: A skid mounted device for upper-spreading internal diffusion vertical plug flow photocatalytic wastewater treatment includes internal diffusion vertical plug flow photocatalytic reaction tank groups and a skid base. The internal diffusion vertical plug flow photocatalytic reaction tank groups are arranged on the skid base. The internal diffusion vertical plug flow photocatalytic reaction tank groups are connected to each other in series, in parallel, or in series-parallel. Each internal diffusion vertical plug flow photocatalytic reaction tank group consists of two or more photocatalytic reaction tanks connected in series, in parallel, or in series-parallel. The wastewater pipes connected to the photocatalytic reaction tanks in each internal diffusion vertical plug flow photocatalytic reaction tank group are mounted above the photocatalytic reaction tanks.Type: ApplicationFiled: May 5, 2018Publication date: April 30, 2020Applicant: YUNNAN UNIVERSITYInventors: Jiaqiang WANG, Wei WANG, Yizhou LI, Liang JIANG
-
Patent number: 10615361Abstract: A layered metal oxide field effect electrode includes multiple metal strips and layered metal oxide films. The band gap width of the first thin metal oxide film material is less than 3 eV; the band gap width of the second thin metal oxide film material is greater than 3 eV; the band gap width of the third thin metal oxide film material is less than 3 eV; the difference between the band gap width of the second thin metal oxide film material and the band gap width of the first thin metal oxide film material is greater than 1 eV; the difference between the band gap width of the second thin metal oxide film material and the band gap width of the third thin metal oxide film material is greater than 1 eV; and the thicknesses of the first thin metal oxide film, the second thin metal oxide film, and the third thin metal oxide film are each smaller than or equal to 10 nm. The layered metal oxide field effect electrode has the advantages of high light transmittance and a good field conduction performance.Type: GrantFiled: October 12, 2018Date of Patent: April 7, 2020Assignee: Yunnan UniversityInventors: Zhenghong Lu, Tao Zhang, Dengke Wang
-
Publication number: 20200062685Abstract: A method for synthesizing 4-(Hydroxymethyl)benzoic acid using P-xylene (PX) as a raw material, including: dissolving PX in an organic solvent to undergo an oxidation reaction with an oxidizing agent under an action of an M-MOF catalyst; and after the oxidation reaction, performing a post-treatment to obtain the 4-(Hydroxymethyl)benzoic acid; wherein, the metal element M in the M-MOF catalyst is Fe, Cu, Cr, Mn, Cu Te, Cu/Cr, Cu/Mn, Fe/Mn, Cr/Fe or Cr/Mn. The by-product produced in the reaction process is little, the yield is high, and the separation is convenient. The acid-base neutralization is not required in the reaction process, reducing pollution. A one-step reaction is employed which has mild reaction conditions, short reaction time, low pollution and is convenient for industrialized mass production; and the obtained 4-(Hydroxymethyl)benzoic acid can be used for preparing medicines and liquid crystal materials having wide applications.Type: ApplicationFiled: May 5, 2018Publication date: February 27, 2020Applicant: YUNNAN UNIVERSITYInventors: Jiaqiang WANG, Ying LI, Daomei CHEN
-
Publication number: 20200006686Abstract: A layered metal oxide field effect material forms a heterojunction from metal oxides with different band gaps, and defines a band gap difference (?E)?1 eV. Band bending is generated at the interface of the heterojunction, such that a potential barrier is formed on the side with the larger band gap and a triangular potential well is formed on the side with the smaller band gap, and under the induction of a gate electric field, a polarized charge is generated at the interface of the heterojunction, and a large number of carriers are accumulated. Therefore, the present layered metal oxide field effect material has high carrier mobility higher than 103 cm2/V·s, and overcomes the problem that the carrier mobility of a conventional metal oxide field effect material is low, it is required to fabricate the metal oxide field effect material into a crystal phase structure with a relatively high cost, and even that a substrate thereof with a crystal phase structure is required.Type: ApplicationFiled: October 12, 2018Publication date: January 2, 2020Applicant: Yunnan UniversityInventors: ZHENGHONG LU, TAO ZHANG, DENGKE WANG
-
Publication number: 20200006695Abstract: A layered metal oxide field effect electrode includes multiple metal strips and layered metal oxide films. The band gap width of the first thin metal oxide film material is less than 3 eV; the band gap width of the second thin metal oxide film material is greater than 3 eV; the band gap width of the third thin metal oxide film material is less than 3 eV; the difference between the band gap width of the second thin metal oxide film material and the band gap width of the first thin metal oxide film material is greater than 1 eV; the difference between the band gap width of the second thin metal oxide film material and the band gap width of the third thin metal oxide film material is greater than 1 eV; and the thicknesses of the first thin metal oxide film, the second thin metal oxide film, and the third thin metal oxide film are each smaller than or equal to 10 nm. The layered metal oxide field effect electrode has the advantages of high light transmittance and a good field conduction performance.Type: ApplicationFiled: October 12, 2018Publication date: January 2, 2020Applicant: Yunnan UniversityInventors: ZHENGHONG LU, TAO ZHANG, DENGKE WANG
-
Patent number: 10475933Abstract: A method for preparing a layered metal oxide field effect material includes depositing a first metal oxide, a core-layer metal, and a second metal oxide sequentially on the substrate by vacuum vapor deposition, the first metal oxide and the core-layer metal undergoing a redox reaction to form a first surface layer and a core-layer precursor on the substrate, and the core-layer precursor and the second metal oxide undergoing a redox reaction to form a core layer and a second surface layer; and the band gap of the metal oxide in the core layer is ?3 eV, the band gaps of the metal oxide in the first surface layer and the second surface layer are independently ?3 eV, and the difference between the band gap of the metal oxide in the core layer and the band gap of the metal oxide in the first surface layer is ?1 eV. The present preparation method has advantages of simple operation, a low production cost, a good film forming property, and the high carrier mobility of the product.Type: GrantFiled: October 12, 2018Date of Patent: November 12, 2019Assignee: Yunnan UniversityInventors: Zhenghong Lu, Tao Zhang, Dengke Wang
-
Publication number: 20170319595Abstract: The invention relates to the field of metal-organic framework materials and the field of medical technology, relates to a method for inhibiting tumor angiogenesis or preventing and/or treating tumor, comprising administering to a subject in need thereof an effective amount of a metal-organic framework comprising Fe and ligand. The invention further relates to a method for inhibiting the expression of matrix metalloproteinase in a cell, comprising administering to the cell an effective amount of a metal-organic framework comprising Fe and ligand.Type: ApplicationFiled: May 8, 2017Publication date: November 9, 2017Applicant: Yunnan UniversityInventors: Bin Li, Daomei Chen, Jiaqiang Wang, Minfang Nie
-
Publication number: 20170312324Abstract: The present invention “use of Maitake and Maitake polysaccharide D Fraction in manufacture of medicaments for anti-depression” belongs to the field of pharmaceuticals, which characterized in that the Maitake whole herb, Maitake extract or Maitake polysaccharide D fraction is used in the preparation of antidepressants. The medicament can be used to treat or prevent depression, which has a significant antidepressant effect, not only strong effect, but also no conventional antidepressant medicaments toxicity, side effects, such as induced epilepsy, ataxia and other shortcomings. Therefore, they can be used as an excellent antidepressant candidate medicament.Type: ApplicationFiled: October 28, 2015Publication date: November 2, 2017Applicant: Yunnan UniversityInventors: Jing DU, Chunjie XIAO, Hongkun BAO, Ming ZHU
-
Patent number: 9328084Abstract: Nitrogen-containing biphenyl compounds as represented by formula (I), pharmaceutically acceptable salts or derivatives thereof, pharmaceutical compositions, and preparation methods therefore, and anti-HIV-1 use of the compound. Each substituent group in formula (I) is as defined in the description.Type: GrantFiled: October 13, 2011Date of Patent: May 3, 2016Assignees: Kunming Institute of Botany, The Chinese Academy of Sciences, Yunnan University, Kunming Institute of Zoology, The Chinese Academy of SciencesInventors: Jingping Liu, Handong Sun, Hongbin Zhang, Yongtang Zheng, Weilie Xiao, Jianxin Pu, Ruirui Wang, Liumeng Yang
-
Patent number: 9131691Abstract: Use of amide compounds represented by formula (I), for preventing or reducing settlement and/or fouling of marine fouling organisms on a surface of a submerged object is provided, wherein “-A-” has a formula —(CnH2(n-m))- which is either unsubstituted or substituted by one or more C1 to C4 alkyls, and wherein the formula —(CnH2(n-m))- represents a divalent alkyl, or a divalent alkenyl having one or more double bonds, n is 1 to 15, m is 0 to 4, and 2(n-m)=2, and R is selected from piperidinyl, pyrrolidinyl, isobutylamino, piperazinyl or morpholinyl. Amide compounds of formula (I), a category of antifouling compounds, can be either isolated from natural resources or synthesized, which are nontoxic and environmental-friendly.Type: GrantFiled: April 17, 2012Date of Patent: September 15, 2015Assignees: The Hong Kong University of Science and Technology, Yunnan University of NatonalitiesInventors: Peiyuan Qian, Xiangzhong Huang, Ying Xu, Yu Zhang, Yue Him Wong, Yan Yin, Zhuang Han