Abstract: Provided herein is a composition comprising a concentrated purified plasma fraction that can be used to treat age-related disorders. Also provided herein are methods for producing a composition comprising a concentrated purified plasma fraction.

Abstract: The present invention provides compositions of GHK-Cu/copper tripeptide to avoid first pass metabolism including transdermal patch compositions. The GHK-Cu/copper tripeptide is preferably in the form of a gel reservoir having polymer and one or more penetration enhancers. The transdermal compositions release GHK-Cu/copper tripeptide in various release patterns to allow 1-7 times delivery of GHK-Cu/copper tripeptide in a week. The transdermal compositions instantly achieve steady state in rats and the concentration is sustained over at least 12 hrs, preferably over 24 hrs.