Patents Assigned to Yuyu Inc.
  • Furancarbonylguanidine derivatives, their preparation and pharmaceutical compositions containing them
    Patent number: 7351843
    Abstract: The present invention relates to furancarbonylguanidine derivatives, a preparation method thereof and a pharmaceutical composition comprising the same. Furancarbonylguanidine derivatives of the present invention inhibit NHE-1 (sodium-hydrogen exchanger isoform 1), which helps recovery of heart function damaged from ischemia/reperfusion and decreases myocardial infarction rate, indicating that they have protective effect on myocardial cells. Thus, furancarbonylguanidine derivatives of the present invention can be effectively used for the prevention and the treatment of ischemic heart diseases such as myocardial infarction, arrhythmia, angina pectoris, etc, and also a promising candidate for a heart protecting agent applied to reperfusion therapy including thrombolytics or cardiac surgery including coronary artery bypass graft, percutaneous transluminal coronary angioplasty, etc.
    Type: Grant
    Filed: December 24, 2004
    Date of Patent: April 1, 2008
    Assignees: Korea Research Institute of Chemical Technology, Yuyu, Inc.
    Inventors: Kyu Yang Yi, Sun Kyung Lee, Nak Jeong Kim, Jee Hee Suh, Soon Hee Hwang, Byung Ho Lee, Ho Won Seo, Sun Kyung Hwang, Sung Eun Yoo, Kyung Hee Lee
  • Glycogen synthase kinase 3? inhibitor, composition and process for the preparation thereof
    Patent number: 7179832
    Abstract: Novel compounds having hydroxybenzoimidazole carboxylic amide are useful for inhibiting glycogen synthase kinase 3?(GSK-3?).
    Type: Grant
    Filed: January 20, 2004
    Date of Patent: February 20, 2007
    Assignees: Crystalgenomics, Inc., Yuyu Inc.
    Inventors: Joong Myung Cho, Seonggu Ro, Tae Gyu Lee, Kyung Joo Lee, Dongkyu Shin, Young-Lan Hyun, Seung Chul Lee, Jin Hwan Kim, Young Ho Jeon