Patents Assigned to ZaCh System
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Patent number: 9920089Abstract: The present invention relates to a process for the preparation of 17-substituted steroids and, more particularly, to an improved method of preparing micro size abiraterone or derivatives thereof in high yield and purity by means of a spherical agglomeration process.Type: GrantFiled: April 11, 2014Date of Patent: March 20, 2018Assignee: ZACH SYSTEMInventors: Patricia Poirier, Yvon Derrien, Massimiliano Forcato, Livius Cotarca, Pierrick Morice
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Patent number: 9604915Abstract: The present invention relates to a process for the cyclopropanation with ethylene carbonate or ethylene sulfate of a compound of formula (II): wherein G is —CN or —COOR in which R is a C1-C4 straight or branched alkyl X and Y are independently selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, R1O— and R1S— wherein R1 is C1-C4 straight or branched alkyl chain.Type: GrantFiled: June 20, 2014Date of Patent: March 28, 2017Assignee: ZACH SYSTEMS S.P.A.Inventors: Massimo Verzini, Livius Cotarca, Alberto Guidi, Alfonso Melloni, Paolo Maragni
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Patent number: 9522869Abstract: A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine hydrochloride salt of formula (I) i.e. Cinacalcet hydrochloride and its intermediates of formulae (VII) and (VIII) wherein Z is chloride or another pharmaceutically acceptable anionic counterion.Type: GrantFiled: June 13, 2014Date of Patent: December 20, 2016Assignee: ZACH SYSTEM S.P.A.Inventors: Nicola Catozzi, Livius Cotarca, Johnny Foletto, Massimiliano Forcato, Roberto Giovanetti, Giorgio Soriato, Massimo Verzini
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Patent number: 9481686Abstract: The present invention relates to a chiral oxamide of formula (I) useful as an intermediate in the preparation of dorzolamide, and to the preparation thereof. The invention also relates to the preparation of dorzolamide, to the hydrochloride salt thereof, and to the active ingredient contained in a drug useful in the treatment of glaucoma, by means of the intermediate of formula (I).Type: GrantFiled: June 28, 2013Date of Patent: November 1, 2016Assignee: ZACH SYSTEM S.P.A.Inventors: Raffaella Volpicelli, Antonio Nardi, Mauro Andretto, Ilaria Munari, Roberto Brescello, Anna Smaniotto, Livius Cotarca, Massimo Verzini
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Patent number: 9481635Abstract: The present invention relates to a process for preparing gabapentin and, more particularly, it relates to a process for the direct extraction of gabapentin from an aqueous solution derived from the Hofmann rearrangement of 1,1-cyclohexanediacetic acid monoamide.Type: GrantFiled: October 21, 2014Date of Patent: November 1, 2016Assignee: ZACH SYSTEM S.P.A.Inventors: Massimo Verzini, Livius Cotarca, Fabio Belluzzo, Giorgio Soriato, Daniele Urbani, Enrico Pace
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Publication number: 20160237025Abstract: The present invention relates to a process for preparing gabapentin and, more particularly, it relates to a process for the direct extraction of gabapentin from an aqueous solution derived from the Hofmann rearrangement of 1,1-cyclohexanediacetic acid monoamide.Type: ApplicationFiled: October 21, 2014Publication date: August 18, 2016Applicant: ZACH SYSTEM S.P.A.Inventors: Massimo Verzini, Livius Cotarca, Fabio Belluzzo, Giorgio Soriato, Daniele Urbani, Enrico Pace
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Patent number: 9353145Abstract: The present invention relates to a process for the preparation of 17-substituted steroids and, more particularly, to an improved method of synthesizing abiraterone or derivatives thereof in high yield and purity by means of a key 3-formate intermediate.Type: GrantFiled: October 9, 2012Date of Patent: May 31, 2016Assignee: ZACH SYSTEMInventors: Yvon Derrien, Patricia Poirier, Massimiliano Forcato, Tony Pintus, Livius Cotarca, Sebastien Meunier, Laurence Graindorge
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Publication number: 20160083416Abstract: The present invention relates to a process for the preparation of 17-substituted steroids and, more particularly, to an improved method of preparing micro size abiraterone or derivatives thereof in high yield and purity by means of a spherical agglomeration process.Type: ApplicationFiled: April 11, 2014Publication date: March 24, 2016Applicant: ZACH SYSTEMInventors: Patricia POIRIER, Yvon DERRIEN, Massimiliano FORCATO, Livius COTARCA, Pierrick MORICE
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Patent number: 9085532Abstract: The present invention relates to a process for preparing a ketosulfone derivative and, more particularly, to an improved method for synthesizing 1-(6-methylpyridin-3-yl)-2-[(4-methylsulfonyl)-phenyl]ethanone by means of Pd-catalized alpha arylation process of a heteroaromatic ketone derivative.Type: GrantFiled: March 8, 2013Date of Patent: July 21, 2015Assignee: ZACH SYSTEM S.P.A.Inventors: Elisa Melotto, Ivan Michieletto, Vincenzo Frega, Livius Cotarca, Massimo Verzini, Franco Massaccesi, Ilaria Munari
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Patent number: 8981127Abstract: The present invention relates to a process for the preparation of nebivolol and, more particularly, to an improved process of synthesizing an alpha-haloketone of formula a key intermediate in the preparation of nebivolol.Type: GrantFiled: September 22, 2009Date of Patent: March 17, 2015Assignee: Zach SystemInventors: Yvon Derrien, Eric Chenard, Alain Burgos
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Patent number: 8969597Abstract: The present invention relates to a process for preparing Nebivolol and, more in particular, to a fractional distillation method of a mixture of stereoisomers of formula intermediates useful in the preparation of nebivolol.Type: GrantFiled: July 23, 2010Date of Patent: March 3, 2015Assignee: Zach System S.p.A.Inventors: Livius Cotarca, Johnny Foletto, Paolo Maragni, Giorgio Soriato, Daniele Urbani, Massimo Verzini
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Patent number: 8933226Abstract: The present invention relates to a process for preparing Bosentan Monohydrate; in particular, the present invention provides the preparation of the novel 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-pyrimidinyl)-pyrimidin-4-yl]-benzenesulfonamide sodium salt as an ethylene glycol solvate (Bosentan sodium salt ethylene glycol solvate), which is a useful intermediate for obtaining Bosentan Monohydrate in a pure form.Type: GrantFiled: September 22, 2011Date of Patent: January 13, 2015Assignee: Zach Systems S.p.A.Inventors: Livius Cotarca, Massimo Verzini, Elisa Melotto, Ivan Michieletto, Alfonso Melloni, Paolo Maragni, Raffaella Volpicelli, Mauro Andretto, Corrado Colli
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Patent number: 8927742Abstract: The present invention relates to a process for preparing Nebivolol and, more particularly, to an improved method of debenzylation of a compound of formula (II) useful for preparing nebivolol endowed with high purity.Type: GrantFiled: October 28, 2009Date of Patent: January 6, 2015Assignee: Zach Systems S.p.A.Inventors: Paolo Maragni, Ivan Michieletto, Raffaella Volpicelli, Giorgio Soriato, Johnny Foletto, Livius Cotarca, Massimo Verzini
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Patent number: 8927740Abstract: The present invention relates to a stereoselective reduction procedure to obtain, by means of catalytic asymmetric hydrogenation by hydrogen transfer, a compound of formula (I) in which X is S or SO2 and R4 is hydrogen or an SO2NH2 group, from the corresponding ketone precursor, said compound of formula (I) being useful as an intermediate in the preparation of dorzolamide or of the hydrochloride salt thereof.Type: GrantFiled: March 8, 2012Date of Patent: January 6, 2015Assignee: Zach System S.P.A.Inventors: Raffaella Volpicelli, Mauro Andretto, Livius Cotarca, Antonio Nardi, Massimo Verzini
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Patent number: 8835655Abstract: The present invention relates to a process for the preparation of olopatadine and, more particularly, to an improved method of synthesizing olopatadine which comprises reacting a dibenz[b,e]oxepin-11-one derivative of formula (III) and a suitable reagent under Witting condition, and to the intermediate 11-[(Z)-3-(dimethylamino)-propylidene]-6-11-dihydrodibenz[b,e]-oxepin-2-acet-amide p-toluensulfonate salt.Type: GrantFiled: February 1, 2010Date of Patent: September 16, 2014Assignee: Zach System S.p.AInventors: Alberto Guidi, Filippo Chiarello, Gianmauro Orru', Massimo Verzini, Livius Cotarca, Jean-Claude Kizirian, Elisenda Trepat Guixer, Francisco Marquillas Olondriz
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Publication number: 20140256932Abstract: The present invention relates to a process for the preparation of 17-substituted steroids and, more particularly, to an improved method of synthesizing abiraterone or derivatives thereof in high yield and purity by means of a key 3-formate intermediate.Type: ApplicationFiled: October 9, 2012Publication date: September 11, 2014Applicant: ZACH SYSTEMInventors: Yvon Derrien, Patricia Poirier, Massimiliano Forcato, Tony Pintus, Livius Cotarca, Sebastien Meunier, Laurence Graindorge
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Publication number: 20140185767Abstract: A method of detecting polymorphs using X-ray produced by a synchrotron source is described. In particular, the method allows to detect particular polymorphs present in small amounts in mixtures of polymorphic compounds present in a prevailing amount. The method offers a powerful resolution of mixtures of polymorph and finds application particularly in the pharmaceutical field.Type: ApplicationFiled: May 16, 2012Publication date: July 3, 2014Applicant: Zach System S.P.A.Inventors: Roberto Brescello, Livius Cotarca, Anna Smaniotta, Massimo Verzini, Maurizio Polentarutti, Giorgio Bais, Jasper Rikkert Plaisier
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Patent number: 8637708Abstract: A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine of formula hydrochloride salt of formula (I) i.e. Cinacalcet.Type: GrantFiled: September 8, 2010Date of Patent: January 28, 2014Assignee: Zach System S.p.A.Inventors: Nicola Catozzi, Livius Cotarca, Johnny Foletto, Massimiliano Forcato, Roberto Giovanetti, Giorgio Soriato, Massimo Verzini
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Patent number: 8614353Abstract: A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine of formula (I) i.e. Cinacalcet and its intermediates of formulae (V), (Va) and (Vb).Type: GrantFiled: October 16, 2009Date of Patent: December 24, 2013Assignee: Zach System S.p.A.Inventors: Nicola Catozzi, Johnny Foletto, Massimiliano Forcato, Roberto Giovanetti, Giorgio Soriato, Massimo Verzini
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Publication number: 20130338377Abstract: The present invention relates to a stereoselective reduction procedure to obtain, by means of catalytic asymmetric hydrogenation by hydrogen transfer, a compound of formula (I) in which X is S or SO2 and R4 is hydrogen or an SO2NH2 group, from the corresponding ketone precursor, said compound of formula (I) being useful as an intermediate in the preparation of dorzolamide or of the hydrochloride salt thereof.Type: ApplicationFiled: March 8, 2012Publication date: December 19, 2013Applicant: ZACH SYSTEM S.P.A.Inventors: Raffaella Volpicelli, Mauro Andretto, Livius Cotarca, Antonio Nardi, Massimo Verzini