Abstract: Disclosed are capture beads that are suitable for use in an assay device which is configured to correlate the capture bead to a specific examination area in the device as well as correlating any captured nucleic acid or other cellular components generated during the assay to that bead.
Type:
Application
Filed:
June 5, 2024
Publication date:
October 31, 2024
Applicant:
Zafrens Inc.
Inventors:
Kandaswamy Vijayan, Ravi Ramenani, Chulmin Choi, Aurelien Laguerre, Gopichandran Ravichandran, Nicholas Sam-Soon, Yi Zhang, David Milliken, Kenneth Chng, Maina Ndungu
Abstract: Disclosed are uniquely labeled perturbation beads used alone or in combination with a capture bead. These perturbation beads are useful in drug discovery especially in assays conducted in a mapped assay device. Such a uniquely labeled perturbation bead, when used in an examination area of a mapped assay device, allows for correlating the sequence of nucleic acids and other components from a lysed cell to the specific examination area where the nucleic acid was retrieved.
Type:
Application
Filed:
June 5, 2024
Publication date:
October 3, 2024
Applicant:
Zafrens Inc.
Inventors:
Kandaswamy Vijayan, Ravi Ramenani, Chulmin Choi, Aurelien Laguerre, Gopichandran Ravichandran, Nicholas Sam-Soon, Yi Zhang, David Milliken, Kenneth Chng, Maina Ndungu
Abstract: A method of cellular analysis at high throughput is provided. More specifically, the invention relates to capturing single cells, culturing single cells to generate clonal copies of single cells, perturbing the single cells or the clonal copies derived from the single cells, performing experiments on single cells or clonal copies of single cells, imaging cells, capturing genomic content and other material from cells and being able to relate the captured genomic information to the functional and imaging analysis performed on the same cell.
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