Patents Assigned to Zaidan Hojin Biseibutsu Kagaku Kai
  • Actinonin derivatives and pharmaceutically acceptable salts thereof
    Patent number: 5206384
    Abstract: A novel actinonin derivative and a salt thereof are provided, which are useful as enzyme inhibitors and particularly have strong inhibitory activities against enkephalinase and angiotensin-converting enzymes. This actinonin derivative is represented by general formula (I): ##STR1## wherein R.sup.1 is sulfoxymethyl or carboxyl or a substituted carboxyl group selected from carboxamide, hydroxyaminocarbonyl and alkoxycarbonyl groups; and R.sup.2 is hydroxyl, alkoxy, hydroxyamino or sulfoxyamino group.
    Type: Grant
    Filed: September 4, 1991
    Date of Patent: April 27, 1993
    Assignees: Zaidan Hojin Biseibutsu Kagaku Kai, Meiji Seika Kaisha Ltd.
    Inventors: Seiji Shibahara, Yoshiyuki Koyama, Shigeharu Inoue, Mitsugu Hachisu, Shinichi Kondo, Takaaki Aoyagi, Tomio Takeuchi
  • Pharmaceutical composition and method for angiogenesis inhibition
    Patent number: 5134156
    Abstract: Actinonin or a salt thereof is active as an inhibitor of angiogenesis in a mammal and is useful as a therapeutic agent for inhibiting angiogenesis in a mammal having diabetic retinopathy or inflammatory response accompanied by angiogenesis.
    Type: Grant
    Filed: September 19, 1990
    Date of Patent: July 28, 1992
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kai
    Inventors: Takao Iwaguchi, Mariko Shimamura, Shingo Uchida, Takaaki Aoyagi, Tomio Takeuchi