Patents Assigned to ZBiotics Company
  • Gene expression system for probiotic microorganisms
    Patent number: 11975033
    Abstract: Provided herein are recombinant microorganisms that express a subject polypeptide. Microorganisms can comprise an expression construct comprising a flagellin promoter operatively linked with a heterologous nucleotide sequence encoding the subject polypeptide. The flagellin promoter sequence can comprise a genetic modification that reduces CsrA inhibition of translation. Microorganisms also can comprise a genetic modification that reduces FlgM inhibition of SigD initiation of transcription. The target polypeptide can be an aldehyde dehydrogenase. Such microorganisms are useful in the treatment of alcohol hangover.
    Type: Grant
    Filed: October 26, 2020
    Date of Patent: May 7, 2024
    Assignee: ZBiotics Company
    Inventor: Zachary Abbott
  • Gene expression system for probiotic microorganisms
    Patent number: 11696932
    Abstract: Provided herein are recombinant microorganisms that express a subject polypeptide. Microorganisms can comprise an expression construct comprising a flagellin promoter operatively linked with a heterologous nucleotide sequence encoding the subject polypeptide. The flagellin promoter sequence can comprise a genetic modification that reduces CsrA inhibition of translation. Microorganisms also can comprise a genetic modification that reduces FlgM inhibition of SigD initiation of transcription. The target polypeptide can be an aldehyde dehydrogenase. Such microorganisms are useful in the treatment of alcohol hangover.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: July 11, 2023
    Assignee: ZBiotics Company
    Inventor: Zachary Abbott
  • Gene expression system for probiotic microorganisms
    Patent number: 10849938
    Abstract: Provided herein are recombinant microorganisms that express a subject polypeptide. Microorganisms can comprise an expression construct comprising a flagellin promoter operatively linked with a heterologous nucleotide sequence encoding the subject polypeptide. The flagellin promoter sequence can comprise a genetic modification that reduces CsrA inhibition of translation. Microorganisms also can comprise a genetic modification that reduces FlgM inhibition of SigD initiation of transcription. The target polypeptide can be an aldehyde dehydrogenase. Such microorganisms are useful in the treatment of alcohol hangover.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: December 1, 2020
    Assignee: ZBiotics Company
    Inventor: Zachary Abbott