Patents Assigned to Zebra Biologies, Inc.
  • TrkB agonist antibodies and methods for treating an ocular degenerative disorder characterized by degeneration of retinal ganglion cells (RGCs)
    Patent number: 10975152
    Abstract: The invention provides TrkB agonist antibodies or antigen-binding fragments that specifically enhance TrkB signaling activities. The invention also provides therapeutic methods of using such antibodies for promoting survival and regeneration of retinal ganglion cells, and for treating or preventing subjects suffering from or at risk of developing various neurodegenerative conditions such as glaucoma.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: April 13, 2021
    Assignees: The Scripps Research Institute, Zebra Biologies, Inc.
    Inventors: Richard A. Lerner, Ronald M. Lindsay, Jia Xie