Abstract: A composition including an amphiphilic compound capable of self-assembling into liquid crystalline particles and a statin for systemic administration via oral mucosa. A method of lowering blood cholesterol levels in a subject comprising administering the self-assembling liquid crystalline particles and statin via oral mucosa. Preferred dosage forms result in prolonged release of the statin.
Type:
Grant
Filed:
April 20, 2018
Date of Patent:
May 2, 2023
Assignee:
Zeenar Enterprises Pty Ltd
Inventors:
Gregory Yu Foo Szto, Tomer Madmon, David Kannar
Abstract: An oral disintegrating tablet (ODT) comprising an active ingredient, about 1 to about 20% w/w of at least one amphiphilic compound, about 1 to about 60% w/w of at least one disintegrant and about 0.5 to about 5% w/w of at least one binder, wherein the ODT has hardness of at least about 1 kp and wherein, when the ODT contacts a hydrophilic solvent, the amphiphilic compound self-assembles into liquid crystalline particles.
Abstract: The present invention provides a composition including an amphiphilic compound capable of self-assembling into a liquid crystalline phase; and a niacin compound. In another aspect, the present invention provides a method for the treatment of a disease state comprising administering a therapeutically effective amount of a pharmaceutical composition incorporating that composition.
Type:
Grant
Filed:
September 16, 2018
Date of Patent:
July 2, 2019
Assignee:
ZEENAR ENTERPRISE PTY LTD
Inventors:
Xavier Mulet, Gregory Yu Foo Szto, David Kannar
Abstract: The present invention provides a composition including an amphiphilic compound capable of self-assembling into a liquid crystalline phase; and a niacin compound.
Type:
Application
Filed:
September 16, 2018
Publication date:
January 17, 2019
Applicant:
Zeenar Enterprises Pty Ltd.
Inventors:
Xavier Mulet, Gregory Yu Foo Szto, David Kannar
Abstract: The present invention provides a composition including an amphiphilic compound capable of self-assembling into a liquid crystalline phase; and a niacin compound. In another aspect, the present invention provides a method for the treatment of a disease state comprising administering a therapeutically effective amount of a pharmaceutical composition incorporating that composition.
Type:
Grant
Filed:
May 9, 2014
Date of Patent:
October 23, 2018
Assignee:
ZEENAR ENTERPRISES PTY LTD
Inventors:
Xavier Mulet, Gregory Yu Foo Szto, David Kannar
Abstract: The present invention provides a composition including an amphiphilic compound capable of self-assembling into a liquid crystalline phase; and a niacin compound.
Type:
Application
Filed:
May 9, 2004
Publication date:
March 24, 2016
Applicant:
Zeenar Enterprises Pty Ltd
Inventors:
Xavier Mulet, Gregory Yu Foo Szto, David Kannar