Abstract: The invention concerns pharmaceutically useful trifluoromethyl ketone substituted di-, tri- and tetra-peptide derivatives of the formulae Ia, Ib, Ic set out hereinafter, and salts thereof which are inhibitors of human leukocyte elastase. Also described herein are pharmaceutical compositions containing a peptide derivative and processes and intermediates for use in the manufacture of the peptide derivatives.

Abstract: The invention concerns pharmaceutically useful trifluoromethyl ketone substituted di-, tri- and tetra-peptide derivatives of the formulae Ia, Ib, Ic set out hereinafter, and salts thereof, which are inhibitors of human leukocyte elastase. Also described herein are pharmaceutical compositions containing a peptide derivative and processes and intermediates for use in the manufacture of the peptide derivatives.

Abstract: The present invention relates to certain peptide derivatives, as described herein, which are human leukocyte elastase (HLE) inhibitors making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated, including treatment of tissue degenerative diseases such as pulmonary emphysema. The invention also includes intermediates useful in the synthesis of these peptide derivatives, processes for preparing them, pharmaceutical compositions containing such peptide derivatives and methods for their use.

Abstract: A water treatment method for controlling the growth of algae, fungi and bacteria and the formation of a waterline residue in recreational and industrial water supplies containing turbulent water utilizes a composition containing a polyhexamethylene biguanide compound and a surfactant. The water treatment method and composition containing the biguanide compound and surfactant are particularly useful for treating recreational water supplies like spas and swimming pools containing turbulent water, such as aerated water.

Abstract: The invention concerns novel, pharmaceutically useful, amide derivatives of certain benzoheterocyclylalkanoic acids (and related tetrazoles and acylsulphonamides) of the formula I and salts thereof, wherein the radicals R.sup.1, R.sup.2, L, X, Y, Z, A.sup.1, Q, A.sup.2 and M have the meanings set out in the specification. The invention also includes pharmaceutical compositions incorporating a formula I compound or a salt thereof, a process for the manufacture of the said compound, together with intermediates for use in the latter process.

Abstract: A composition of matter having a clay porous granule and a polyurethane matrix formed from the polymerization of a polyol and a polyisocyanate and held within the pores of the granule and having uniformly distributed throughout the polyurethane matrix a liquid material, for example, a pesticide and a method for loading a porous granule with the polyurethane and the liquid material by:(a) spraying a porous granule with a liquid composition comprising a polyol, a polyisocyanate and a liquid material to be retained in the porous granule, and(b) polymerizing the polyol and the polyisocyanate to form a polyurethane matrix polymer which has the liquid materials uniformly distributed throughout the polyurethane matrix.

Abstract: The invention concerns novel, pharmaceutically useful, amide derivatives of certain benzoheterocyclylalkanoic acids (and related tetrazoles and acylsulphonamides) of the formula I and salts thereof, wherein the radicals R.sup.1, R.sup.2, L, X, Y, Z, A.sup.1, Q, A.sup.2 and M have the meanings set out in the specification. The invention also includes pharmaceutical compositions incorporating a formula I compound or a salt thereof, a process for the manufacture of the said compound, together with intermediates for use in the latter process.

Abstract: The invention concerns pharmaceutically useful trifluoromethyl ketone substituted di-, tri- and tetra-peptide derivatives of the formulae Ia, Ib, Ic set out hereinafter, and salts thereof, which are inhibitors of human leukocyte elastase. Also described herein are pharmaceutical compositions containing a peptide derivative and processes and intermediates for use in the manufacture of the peptide derivatives.

Abstract: Microwaveable packing compositions exhibiting improved temperature control are provided. These compositions comprise a dielectric substrate having at least a portion of at least one of its surfaces coated with a matrix composition containing susceptor particles as well as particles of a blocking agent selected from the group consisting of calcium salts, zinc salts, zinc oxide, lithopone, silica and titanium dioxide. Also disclosed is a microwaveable ink composition useful for the preparation of such packaging compositions as well as a process for manufacturing such packaging compositions.

Abstract: The invention concerns novel, pharmaceutically useful, amide derivatives of certain benzoheterocyclylalkanoic acids (and related tetrazoles and acylsulphonamides) of the formula I and salts thereof, wherein the radicals R.sup.1, R.sup.2, L, X, Y, Z, A.sup.1, Q, A.sup.2 and M have the meanings set out in the specification. The invention also includes pharmaceutical compositions incorporating a formula I compound or a salt thereof, a process for the manufacture of the said compound, together with intermediates for use in the latter process.

Abstract: A method for preparing oximes where an aldehyde or ketone is reacted with hydroxylamine or its salt in the presence of a catalytic amount of an organotin(IV) compound such as monoalkyltin(IV), dialkyltin(IV) and aryltin(IV). The organotin(IV) compound is represented by the formula I:(R.sup.1).sub.n SnX.sub.m-n (I)where R.sup.1 is independently selected from alkyl of 1 to 18 carbons or aryl, X is halogen, oxygen, hydroxyl, OR.sup.1, R.sup.2 CO.sub.2 --, R.sup.2 O.sub.2 C--(Z).sub.y --CO.sub.2 -- or R.sup.2 CO.sub.2 (CH.sub.2).sub.y S--, R.sup.2 is alkyl of 1 to 18 carbons or aryl, Z is selected from CH.sub.2 or CH.dbd.CH, where y is 0 to 6, n is 1 or 2 and m is 4 except that when X is oxygen, n is 2 and m is 3. Exemplary of the organotin(IV) compounds are butyltin tris(2-ethylhexanoate), dibutyltin diacetate and diphenyltin dichloride.

Abstract: A process is disclosed for the microencapsulation of a substantially water-insoluble liquid material within a porous shell to effect a slow rate of release of said material through said shell which comprises (a) providing an organic solution comprising said material and an etherified urea-formaldehyde prepolymer dissolved therein in which from about 50% to about 98% of the methylol groups of said prepolymer have been etherified with a C.sub.4 -C.sub.